diff -Nru brltty-6.4/debian/changelog brltty-6.4/debian/changelog
--- brltty-6.4/debian/changelog	2022-03-18 14:26:01.000000000 +0000
+++ brltty-6.4/debian/changelog	2022-03-18 16:59:59.000000000 +0000
@@ -1,3 +1,10 @@
+brltty (6.4-4ubuntu2) jammy; urgency=medium
+
+  * Support python3.10's change to the default sysconfig scheme, fixing FTBFS
+    with Python 3.10 by default. (Closes: Bug#1007927)
+
+ -- Stefano Rivera <stefanor@ubuntu.com>  Fri, 18 Mar 2022 12:59:59 -0400
+
 brltty (6.4-4ubuntu1) jammy; urgency=medium
 
   * Resynchornize on Debian, fix the build
diff -Nru brltty-6.4/debian/patches/py310-sysconfig brltty-6.4/debian/patches/py310-sysconfig
--- brltty-6.4/debian/patches/py310-sysconfig	1970-01-01 00:00:00.000000000 +0000
+++ brltty-6.4/debian/patches/py310-sysconfig	2022-03-18 16:59:51.000000000 +0000
@@ -0,0 +1,46 @@
+Description: Handle Debian's default posix_prefix sysconfig layout
+ Debian adds a custom sysconfig scheme to system python installs,
+ "posix_local". This is the default scheme, and it redirects local users'
+ Python module installs to /usr/local even though Python is installed with a
+ /usr prefix. Both are on Debian's python's sys.path module search path.
+ .
+ Previously this custom sysconfig scheme was specified in distutils.sysconfig,
+ but not sysconfig itself. As distutils is being deprecated, the custom scheme
+ is now specified in sysconfig, since Debian's Python 3.10 (3.10.2-4).
+ .
+ As far as I can see, pythoncmd is only used in detecting the installed system
+ python, not determining where the built module will be installed, so this
+ patch is sufficient. To control where the module is installed, the approach
+ would be to pass the selected prefix to sysconfig, when querying the install
+ path.
+Bug-Debian: https://bugs.debian.org/1007927
+Forwarded: https://github.com/brltty/brltty/pull/362
+
+--- a/Tools/pythoncmd
++++ b/Tools/pythoncmd
+@@ -46,15 +46,22 @@
+ try:
+   import sysconfig
+ # putProgramMessage("sysconfig")
++  if hasattr(sysconfig, 'get_default_scheme'):
++    scheme = sysconfig.get_default_scheme()
++  else:
++    scheme = sysconfig._get_default_scheme()
++  if scheme == 'posix_local':
++    # Debian's default scheme installs to /usr/local/ but we want to find headers in /usr/
++    scheme = 'posix_prefix'
+ 
+   def getIncludeDirectory():
+-    return sysconfig.get_path("include")
++    return sysconfig.get_path("include", scheme)
+ 
+   def getLibraryDirectory():
+-    return sysconfig.get_path("stdlib")
++    return sysconfig.get_path("stdlib", scheme)
+ 
+   def getPackageDirectory():
+-    return sysconfig.get_path("platlib")
++    return sysconfig.get_path("platlib", scheme)
+ 
+   def getConfigurationVariable(name):
+     return sysconfig.get_config_var(name)
diff -Nru brltty-6.4/debian/patches/series brltty-6.4/debian/patches/series
--- brltty-6.4/debian/patches/series	2021-11-16 16:25:42.000000000 +0000
+++ brltty-6.4/debian/patches/series	2022-03-18 16:59:56.000000000 +0000
@@ -3,3 +3,4 @@
 41-java-bytecode-compat.patch
 disable-synth-callback.patch
 socket-permissions
+py310-sysconfig