diff -Nru python-biopython-1.78+dfsg/debian/changelog python-biopython-1.78+dfsg/debian/changelog
--- python-biopython-1.78+dfsg/debian/changelog	2021-04-05 12:12:51.000000000 +0000
+++ python-biopython-1.78+dfsg/debian/changelog	2021-08-30 15:59:01.000000000 +0000
@@ -1,8 +1,19 @@
-python-biopython (1.78+dfsg-4ubuntu1) hirsute; urgency=medium
+python-biopython (1.78+dfsg-5ubuntu1) impish; urgency=medium
 
-  * Depend on python3-renderpm in the autopkg tests.
+  * Upgrade dependency on python3-renderpm from Suggests to
+    Depends to fix test failure with python-reportlab 3.5.66
 
- -- Matthias Klose <doko@ubuntu.com>  Mon, 05 Apr 2021 14:12:51 +0200
+ -- Graham Inggs <ginggs@ubuntu.com>  Mon, 30 Aug 2021 15:59:01 +0000
+
+python-biopython (1.78+dfsg-5) unstable; urgency=medium
+
+  * d/control: update uploader address
+  * d/watch: fix broken url to github
+  * d{,/tests}/control: add full_suite autopkgtest (Closes: #986410)
+  * Standards-Version: 4.6.0 (routine-update)
+  * Use secure URI in Homepage field.
+
+ -- Étienne Mollier <emollier@debian.org>  Sun, 22 Aug 2021 21:56:28 +0200
 
 python-biopython (1.78+dfsg-4) unstable; urgency=medium
 
diff -Nru python-biopython-1.78+dfsg/debian/control python-biopython-1.78+dfsg/debian/control
--- python-biopython-1.78+dfsg/debian/control	2020-12-05 22:32:40.000000000 +0000
+++ python-biopython-1.78+dfsg/debian/control	2021-08-30 13:18:26.000000000 +0000
@@ -1,10 +1,13 @@
 Source: python-biopython
-Maintainer: Debian Med Packaging Team <debian-med-packaging@lists.alioth.debian.org>
+Maintainer: Ubuntu Developers <ubuntu-devel-discuss@lists.ubuntu.com>
+XSBC-Original-Maintainer: Debian Med Packaging Team <debian-med-packaging@lists.alioth.debian.org>
 Uploaders: Charles Plessy <plessy@debian.org>,
            Andreas Tille <tille@debian.org>,
-           Étienne Mollier <etienne.mollier@mailoo.org>
+           Étienne Mollier <emollier@debian.org>
 Section: python
 Priority: optional
+# note: all build-dependencies marked <!nocheck>, should be tested against in
+# the full_suite autopkgtest as well.
 Build-Depends: debhelper-compat (= 13),
                dh-python,
                python3-all-dev,
@@ -45,10 +48,10 @@
                samtools <!nocheck>,
                t-coffee <!nocheck>,
                wise <!nocheck>
-Standards-Version: 4.5.1
+Standards-Version: 4.6.0
 Vcs-Browser: https://salsa.debian.org/med-team/python-biopython
 Vcs-Git: https://salsa.debian.org/med-team/python-biopython.git
-Homepage: http://biopython.org
+Homepage: https://biopython.org
 Rules-Requires-Root: no
 
 Package: python3-biopython
@@ -56,6 +59,7 @@
 Depends: ${python3:Depends},
          ${shlibs:Depends},
          ${misc:Depends},
+         python3-renderpm,
          python3-reportlab
 Recommends: python-biopython-doc (= ${source:Version}),
             ncbi-blast+ (>= 2.10.1-3)
@@ -79,7 +83,6 @@
           python3-numpy,
           python3-pil,
           python3-rdflib,
-          python3-renderpm,
           python3-psycopg2,
           python3-scipy,
           raxml,
diff -Nru python-biopython-1.78+dfsg/debian/tests/control python-biopython-1.78+dfsg/debian/tests/control
--- python-biopython-1.78+dfsg/debian/tests/control	2021-04-05 12:12:15.000000000 +0000
+++ python-biopython-1.78+dfsg/debian/tests/control	2021-08-30 13:17:43.000000000 +0000
@@ -1,3 +1,12 @@
-Tests: run-unit-test
-Depends: @, python3-setuptools, python3-all, python3-renderpm
+# autopkgtest checking dependencies are fulfilled
+Features: test-name=dependencies
+Test-Command: sh debian/tests/run-unit-test
+Depends: @, python3-setuptools, python3-all
 Restrictions: allow-stderr
+
+# autopkgtest checking every test runs fine; dependencies list should match the
+# list of build-dependencies from d/control; see #986410 for a rationale.
+Features: test-name=full_suite
+Test-Command: sh debian/tests/run-unit-test
+Depends: @, @builddeps@
+Restrictions: allow-stderr, skip-not-installable
diff -Nru python-biopython-1.78+dfsg/debian/watch python-biopython-1.78+dfsg/debian/watch
--- python-biopython-1.78+dfsg/debian/watch	2020-09-09 20:43:24.000000000 +0000
+++ python-biopython-1.78+dfsg/debian/watch	2021-08-22 17:54:46.000000000 +0000
@@ -1,4 +1,11 @@
 version=4
 
-opts="uversionmangle=s/b/~b/;s/(\d)(\d+)/$1.$2/,repacksuffix=+dfsg,dversionmangle=s/\+dfsg//,repack,compression=xz" \
-  https://github.com/biopython/biopython/releases .*/archive/biopython-(\d[\d.-]+)\.(?:tar(?:\.gz|\.bz2)?|tgz)
+opts="\
+filenamemangle=s%(?:.*?)?v?(\d[\d.]*)\.tar\.gz%@PACKAGE@-$1.tar.gz%,\
+uversionmangle=s/b/~b/;s/(\d)(\d+)/$1.$2/,\
+repacksuffix=+dfsg,\
+dversionmangle=s/\+dfsg//,\
+repack,\
+compression=xz" \
+	https://github.com/biopython/biopython/tags \
+	(?:.*?/)?biopython[v-]?(\d[\d.]*)\.tar\.gz debian uupdate