Alternative node coloring

@@ -1417,6 +1425,10 @@

References

Mykhaylo Slobodyanyuk^, Alexander T. Bahcheli^, Zoe P. Klein, +Masroor Bayati, Lisa J. Strug, Jüri Reimand. Directional integration and +pathway enrichment analysis for multi-omics data. bioRxiv (2023-09-24) +(^ - co-first authors) https://www.biorxiv.org/content/10.1101/2023.09.23.559116v1.
Integrative Pathway Enrichment Analysis of Multivariate Omics Data. Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation diff -Nru activepathways-2.0.2/inst/doc/ActivePathways-vignette.R activepathways-2.0.3/inst/doc/ActivePathways-vignette.R --- activepathways-2.0.2/inst/doc/ActivePathways-vignette.R 2023-10-02 04:25:02.000000000 +0000 +++ activepathways-2.0.3/inst/doc/ActivePathways-vignette.R 2023-10-31 19:24:43.000000000 +0000 @@ -85,15 +85,16 @@ ggplot(lineplot_df) + geom_point(size = 2.4, shape = 19, aes(original, modified, - color = ifelse(modified <= -log10(0.05), "#de2d26", "#2ca25f"))) + + color = ifelse(original <= -log10(0.05),"gray", + ifelse(modified > -log10(0.05),"#1F449C","#F05039")))) + labs(title = "", x ="Merged -log10(P)", y = "Directional Merged -log10(P)") + geom_hline(yintercept = 1.301, linetype = "dashed", - col = 'black', linewidth = 0.5) + + col = 'black', size = 0.5) + geom_vline(xintercept = 1.301, linetype = "dashed", - col = "black", linewidth = 0.5) + - geom_abline(linewidth = 0.5, slope = 1,intercept = 0) + + col = "black", size = 0.5) + + geom_abline(size = 0.5, slope = 1,intercept = 0) + scale_color_identity() ## ----------------------------------------------------------------------------- diff -Nru activepathways-2.0.2/inst/doc/ActivePathways-vignette.Rmd activepathways-2.0.3/inst/doc/ActivePathways-vignette.Rmd --- activepathways-2.0.2/inst/doc/ActivePathways-vignette.Rmd 2023-10-02 04:01:37.000000000 +0000 +++ activepathways-2.0.3/inst/doc/ActivePathways-vignette.Rmd 2023-10-31 19:23:17.000000000 +0000 @@ -26,6 +26,11 @@ ActivePathways is a tool for multivariate pathway enrichment analysis that identifies gene sets, such as pathways or Gene Ontology terms, that are over-represented in a list or matrix of genes. ActivePathways uses a data fusion method to combine multiple omics datasets, prioritizes genes based on the significance and direction of signals from the omics datasets, and performs pathway enrichment analysis of these prioritized genes. We can find pathways and genes supported by single or multiple omics datasets, as well as additional genes and pathways that are only apparent through data integration and remain undetected in any single dataset alone. +The new version of ActivePathways is described in our recent preprint. + +Mykhaylo Slobodyanyuk^, Alexander T. Bahcheli^, Zoe P. Klein, Masroor Bayati, Lisa J. Strug, Jüri Reimand. Directional integration and pathway enrichment analysis for multi-omics data. bioRxiv (2023-09-24) (^ - co-first authors) +https://www.biorxiv.org/content/10.1101/2023.09.23.559116v1 + The first version of ActivePathways was published in Nature Communications with the PCAWG Pan-Cancer project. Marta Paczkowska\^, Jonathan Barenboim\^, Nardnisa Sintupisut, Natalie S. Fox, Helen Zhu, Diala Abd-Rabbo, Miles W. Mee, Paul C. Boutros, PCAWG Drivers and Functional Interpretation Working Group, PCAWG Consortium, Juri Reimand. Integrative pathway enrichment analysis of multivariate omics data. Nature Communications 11 735 (2020) (\^ - co-first authors) @@ -161,7 +166,7 @@ directional_merged_pvals["PIK3R4"] ``` -To assess the impact of the directional penalty on gene merged P-value signals we create a plot showing directional results on the y axis and non-directional results on the x. Green dots are prioritised hits, red dots are penalised. +To assess the impact of the directional penalty on gene merged P-value signals we create a plot showing directional results on the y axis and non-directional results on the x. Blue dots are prioritised hits, red dots are penalised. ```{r} lineplot_df <- data.frame(original = -log10(merged_pvals), @@ -170,15 +175,16 @@ ggplot(lineplot_df) + geom_point(size = 2.4, shape = 19, aes(original, modified, - color = ifelse(modified <= -log10(0.05), "#de2d26", "#2ca25f"))) + + color = ifelse(original <= -log10(0.05),"gray", + ifelse(modified > -log10(0.05),"#1F449C","#F05039")))) + labs(title = "", x ="Merged -log10(P)", y = "Directional Merged -log10(P)") + geom_hline(yintercept = 1.301, linetype = "dashed", - col = 'black', linewidth = 0.5) + + col = 'black', size = 0.5) + geom_vline(xintercept = 1.301, linetype = "dashed", - col = "black", linewidth = 0.5) + - geom_abline(linewidth = 0.5, slope = 1,intercept = 0) + + col = "black", size = 0.5) + + geom_abline(size = 0.5, slope = 1,intercept = 0) + scale_color_identity() ``` @@ -472,7 +478,7 @@ 1. Cytoscape, see 2. EnrichmentMap app of Cytoscape, see menu Apps\>App manager or -3. EhancedGraphics app of Cytoscape, see menu Apps\>App manager or +3. EnhancedGraphics app of Cytoscape, see menu Apps\>App manager or ## Required files @@ -595,6 +601,9 @@ # References +- Mykhaylo Slobodyanyuk^, Alexander T. Bahcheli^, Zoe P. Klein, Masroor Bayati, Lisa J. Strug, Jüri Reimand. Directional integration and pathway enrichment analysis for multi-omics data. bioRxiv (2023-09-24) (^ - co-first authors) +. + - Integrative Pathway Enrichment Analysis of Multivariate Omics Data. Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group; Reimand J, PCAWG Consortium. Nature Communications (2020) . - Pathway Enrichment Analysis and Visualization of Omics Data Using g:Profiler, GSEA, Cytoscape and EnrichmentMap. Reimand J, Isserlin R, Voisin V, Kucera M, Tannus-Lopes C, Rostamianfar A, Wadi L, Meyer M, Wong J, Xu C, Merico D, Bader GD. Nature Protocols (2019) . Binary files /tmp/tmpae69_xmc/BguR974WpW/activepathways-2.0.2/inst/extdata/enrichmentMap__legend.pdf and /tmp/tmpae69_xmc/6UxDiqj40c/activepathways-2.0.3/inst/extdata/enrichmentMap__legend.pdf differ diff -Nru activepathways-2.0.2/inst/extdata/enrichmentMap__pathways.gmt activepathways-2.0.3/inst/extdata/enrichmentMap__pathways.gmt --- activepathways-2.0.2/inst/extdata/enrichmentMap__pathways.gmt 2023-10-02 01:21:34.000000000 +0000 +++ activepathways-2.0.3/inst/extdata/enrichmentMap__pathways.gmt 2023-10-31 18:58:47.000000000 +0000 @@ -1,20 +1,33 @@ -REAC:2424491 DAP12 signaling IL17RD PSMC1 PDGFRB PSMD14 TNRC6C CD80 DUSP10 SPTBN4 PIP5K1B NRG1 TNRC6A FGF22 ADCY5 CHUK PSME2 CUL3 NRG2 PSMB8 PSMA2 PSMB3 PSMD13 AC010132.3 PIK3CB FGF18 PRKCE FN1 SHC2 RBX1 PSMD5 FGF19 NF1 ARRB1 FGFR1 PRKACG FGB PSME1 VAV1 PSMD3 ITGA2B HBEGF ERBB3 FGF3 KSR2 PPP2R5C VAV3 PPP2CB IL5RA PSMB9 CDKN1B RASA2 PPP2R5E PIK3AP1 PSMF1 FOXO4 PSMC3 PSMA6 AL358075.4 FGF2 ICOS IL2RB BTC ADCY2 RAPGEF2 CDKN1A DUSP6 ERBB4 PTK2 MET FGA TSC2 NRAS SPTB SPRED3 TNRC6B FOXO3 GSK3A FGF1 IL3RA PIP5K1A IL2RA GFRA4 PSMD1 TEK RICTOR PSMD10 CASP9 CAMK2G RASAL3 PPP2R1A PSMB6 FGF6 IL3 MAPKAP1 SYK CNKSR1 RASGRF2 GRIN2C PSMB7 CD86 ADCY3 TLN1 PSMC4 HRAS MLST8 VAV2 LAMTOR2 THEM4 DUSP7 RASGRF1 CALM3 RAP1B PSMC2 KSR1 RAC1 ADCY1 JAK1 SPRED2 PDE1A FGF10 PSME4 EGF PDE1B GRIN2A IRS2 VWF PIK3CD FGFR4 PHB AKT1 IQGAP1 PTPRA PSMB1 PRKAR1B KL PRKCD PSMD9 PSMB2 EGFR MAP2K2 PRKAR2B KRAS CAMK2D SRC PIK3CA NRTN IL2 CAMK2B KIT CSF2RA CSK UBC SPTBN1 RASA4 CD19 DUSP2 LAMTOR3 ADCY4 PHLPP2 ARAF PSMD2 PDGFB PSMA8 FGFR3 NEFL TRAT1 MIR26A2 FGF23 AGO3 PTPN11 PSMB10 GAB1 MAPK1 TREM2 PRKAR2A LCK ADCY6 SPRED1 MIR26A1 SPTAN1 PSMB11 PDPK1 ITPR3 KBTBD7 RET PSMD8 FGG GFRA1 AHCYL1 FOXO1 PIK3R1 RASGEF1A JAK2 B2M FGF20 PIK3R2 FGF4 RASAL1 FGF7 PIP4K2C PDGFA PRR5 TYROBP EREG PPP2R5B GRAP2 SOS1 DUSP8 PRKACA RASA1 PSMA5 DUSP4 PRKCA ADCY7 CSF2 DUSP16 PHLPP1 CAMK4 KLB GDNF AKT2 CREB1 PPP2CA FGF8 FGF9 ITPR2 BAD PAQR3 SYNGAP1 APBB1IP SEM1 RPS6KB2 AKT1S1 PPP5C PLCG1 PSMA7 SHC1 ARTN PRKCG PSMA3 KITLG GRK2 AKAP9 ANGPT1 FGF17 MTOR PDE1C GRIN2B NR4A1 ITGB3 PSMC5 AGO1 KLRD1 BRAF AKT3 PSMD4 PIP4K2A TRIB3 RASA3 MDM2 PSMA4 SPTBN2 DAB2IP DUSP5 PSMB4 PSMA1 MAPK3 KLRK1 GSK3B PDGFRA CAMK2A VCL GFRA2 ITPR1 KLRC2 LCP2 ERBB2 GRIN1 GRB2 LAT RAF1 SPTA1 RANBP9 PIP4K2B FRS3 INS-IGF2 RASGRP3 SHC3 IER3 INSR BRAP PEBP1 CD28 GRIN2D FYN YWHAB IL5 AGO4 UBB FGF16 IL2RG FGF5 PSMC6 IRS1 PPP2R1B ARRB2 MARK3 BTK PLCG2 RAP1A PEA15 PSMD6 ADCY8 JAK3 SPTBN5 ACTN2 PPP2R5A MAP3K11 DUSP1 DUSP9 RPS27A CSF2RB HLA-E AL672043.1 RASAL2 CALM1 PIK3R3 FRS2 PRKAR1A ADCY9 FGFR2 DLG4 PPP2R5D CNKSR2 NCAM1 RASGRP4 PSMD12 PSMB5 TP53 WDR83 NRG4 PRKACB MAP2K1 MOV10 PIP5K1C NRG3 CALM2 PTEN UBA52 PSMD7 RNASE1 PSPN GFRA3 PSMD11 INS RASGRP1 AGO2 HGF PSME3 -REAC:422475 Axon guidance SEMA3E PSME4 FGF10 TIAM1 RGMA JAK1 CD72 GRB7 COL6A5 PSMC2 SRGAP2 LAMTOR2 PAK4 VAV2 SEMA4A HRAS TLN1 PSMB7 KALRN RASGRF2 UNC5D DCC RAC2 CNKSR1 FES ARPC2 SRGAP3 EPHA4 LAMC1 PSMD10 CLASP2 MYL12A CDK5R1 GPC1 GFRA4 COL6A2 NEO1 LAMTOR3 EFNA1 UBC SCN9A CACNB3 IL2 WASL NRTN PIK3CA KRAS CHL1 CFL1 CRMP1 PRNP MAP2K2 EPHB4 EGFR PSMD9 PSMB2 EPHA1 KL PHB ABLIM1 PIK3CD TRPC7 ACTG1 CNTN6 RPS6KA5 PSENEN ACTB CD24 PPP2R5C ITGB1 ROCK2 ERBB3 ITGA2B NGEF HBEGF PSMD3 FGB ARRB1 DPYSL5 ABLIM2 PSMD5 RPS6KA1 PLXNA4 RBX1 FN1 SHC2 PIK3CB PAK6 PSMB3 CUL3 NRG2 SHANK3 ACTR3 CLTB CNTN1 ARHGEF12 SPTBN4 SCN3B ITGA10 PSMC1 CAP1 IL2RA RHOC EFNA5 COL6A6 NRAS NRP1 PLXNC1 SCN3A APH1A MET FGA PTK2 FARP2 ERBB4 DUSP6 RPS6KA2 ABL1 SCN2A RRAS EPHB2 SEMA3A BTC FGF2 AL358075.4 ARHGEF7 NCK1 NTN4 PPP2R5E CNTNAP1 RASA2 IL5RA SDCBP EFNB3 RAP1A MARK3 PPP2R1B IRS1 TRIO EPHA2 PSMC6 FGF5 EFNA4 IL2RG COL4A2 FGF16 IL5 YWHAB FYN GRIN2D RAP1GAP GAB2 BRAP RASGRP3 ROBO1 EPHA8 KIRREL RANBP9 LAT PLXNB3 COL6A3 GRB2 ERBB2 GFRA2 VCL CAMK2A GSK3B PSMA1 PSMD11 CLTC SCN7A APH1B EPHA6 MAP2K1 PRKACB PFN2 WDR83 PSMB5 NCAM1 ROBO3 PPP2R5D PAK2 TRPC3 FRS2 DOK6 RDX SCN10A ARPC1A EPHA3 CSF2RB MAP3K11 ACTN2 JAK3 SPTBN5 PSMD6 UNC5B ARHGEF28 PEA15 DUSP16 PRKCA SCN5A SHB PSMA5 RASA1 PRKACA AP2B1 SOS1 VASP TYROBP RND1 UNC5C MYL6 CACNA1D RASAL1 NCSTN JAK2 SDC2 FGF20 EFNB2 PSMD8 FGG RET SEMA4D SPRED1 DPYSL4 CDC42 MAPK1 GAB1 PSMB10 SLIT2 SLIT3 FGFR3 PSMA8 AP2A1 PDGFB PSMD2 LAMA1 DUSP5 COL9A3 DAB2IP SPTBN2 BUB1B-PAK6 BRAF ROCK1 PSEN2 TRPC5 L1CAM ITGB3 PLXND1 LAMB1 PAK1 AKAP9 KITLG ARTN NCK2 ITGA2 SEM1 AP2M1 APBB1IP ANK1 SYNGAP1 FGF9 RPS6KA6 FGF8 SH3KBP1 KLB DOK1 TRPC6 NFASC EGF COL4A3 SPRED2 DNM2 RAC1 SEMA7A SEMA6D KSR1 ALCAM COL4A1 RAP1B CLASP1 CALM3 RASGRF1 DUSP7 EFNA3 GIT1 DPYSL2 ARHGAP35 PSMC4 EPHA5 ENAH RPS6KA4 GRIN2C KIF4B IL3 PSMB6 FGF6 PPP2R1A RASAL3 CAMK2G ITGA5 ARHGEF11 ABL2 PSMD1 TEK ADAM10 DLG1 MYH10 RELN CACNA1S PLXNA3 DUSP2 RASA4 SPTBN1 ARPC1B CSK ITGA1 CSF2RA KIT HFE2 SEMA5A CAMK2B COL9A2 SRC CAMK2D UNC5A CACNA1C DCX LYPLA2 MMP9 VLDLR SCN8A IQGAP1 PTPRA PSMB1 AP2S1 FGFR4 VWF CLTCL1 SCN4A IRS2 GRIN2A HSP90AA1 VAV3 KSR2 FGF3 PSME1 RHOB PRKACG FGFR1 SCN11A NF1 FGF19 MYO10 CACNA1I FGF18 AC010132.3 PSMA2 PSMD13 SEMA6A PSMB8 PTPRC PSME2 FGF22 CSNK2A2 PAK3 AP2A2 PITPNA DOK5 NRG1 EPHB6 DUSP10 SLIT1 ABLIM3 SRGAP1 PSMD14 PDGFRB IL17RD IL3RA ARPC5 FGF1 PLXNB1 ITGAV CSNK2B SPRED3 SPTB MYL9 AGRN CLTA RPS6KA3 ITSN1 DOK2 YES1 RAPGEF2 ARPC4 ARPC3 SIAH2 GAP43 IL2RB LYN ACTR2 PSMC3 PSMA6 HSPA8 PSMF1 PRKCQ PSMB9 DOK4 SHTN1 PPP2CB DNM1 DPYSL3 ARRB2 GRB10 ANK2 CDK5 CACNB4 RHOG UBB KDR CSNK2A1 SCN2B PEBP1 MYH14 SHC3 RGMB NRCAM EPHB1 SCN4B EVL FRS3 VEGFA HSP90AB1 DAB1 SPTA1 RAF1 EFNA2 PAK5 GRIN1 SCN1A COL4A4 PDGFRA TRPC4 MAPK3 NCAN PSME3 KIF4A AGAP2 HGF RASGRP1 RNASE1 PSPN GFRA3 PSMD7 UBA52 CALM2 NRG3 PIP5K1C ITGA9 DOCK1 NRG4 ANK3 PSMD12 RASGRP4 CNKSR2 SH3GL2 DLG4 FGFR2 PFN1 PLXNA2 PIK3R3 CALM1 NUMB ROBO2 RASAL2 AL672043.1 RPS27A CACNB1 TRPC1 DUSP9 DUSP1 ST8SIA2 DLG3 PPP2R5A RHOA SCN1B KCNQ3 ARHGAP39 EPHA7 CAP2 CSF2 DUSP4 LIMK1 COL4A5 MYH11 SOS2 MYL12B DUSP8 PPP2R5B EREG FGF7 PDGFA SIAH1 MMP2 FGF4 PIK3R2 DNM3 RASGEF1A PIK3R1 CACNA1G GFRA1 CNTN2 KBTBD7 PSMB11 SPTAN1 CACNA1H TREM2 EFNB1 PTPN11 FGF23 NEFL ARAF PSMB4 ST8SIA4 PSMA4 RASA3 COL6A1 PSMD4 NRP2 EZR MYH9 MAPK7 NTN1 LIMK2 PSMC5 GRIN2B COL9A1 FGF17 ANGPT1 PDLIM7 PSMA3 EPHA10 EPHB3 SHC1 PSMA7 KCNQ2 PLCG1 PLXNA1 PPP5C PAQR3 GDNF PPP2CA CREB1 MSN CACNB2 -REAC:177929 Signaling by EGFR ADCY3 HRAS PSMC4 TLN1 MLST8 THEM4 LAMTOR2 CALM3 RASGRF1 DUSP7 PSMC2 RAP1B KSR1 ADCY1 CBL JAK1 SPRED2 PDE1A FGF10 PSME4 EGF ADAM10 GFRA4 PSMD1 TEK RICTOR PSMD10 CASP9 CAMK2G RASAL3 PSMB6 FGF6 PPP2R1A MAPKAP1 IL3 CNKSR1 LRIG1 RASGRF2 GRIN2C CD86 PSMB7 KRAS CAMK2D SRC NRTN PIK3CA IL2 CAMK2B CSF2RA KIT UBC CSK RASA4 SPTBN1 LAMTOR3 CD19 DUSP2 ADCY4 PHLPP2 PDE1B GRIN2A IRS2 PIK3CD VWF FGFR4 PHB PRKAR1B PSMB1 IQGAP1 PTPRA AKT1 PRKCD KL HGS SH3GL3 PSMB2 PSMD9 EGFR MAP2K2 PRKAR2B AC010132.3 PIK3CB FGF18 PRKCE RBX1 FN1 SHC2 PSMD5 FGF19 PRKACG ARRB1 FGFR1 NF1 FGB PSME1 VAV1 HBEGF ITGA2B ERBB3 PSMD3 FGF3 EPS15 KSR2 PPP2R5C ADAM12 IL17RD PSMD14 PSMC1 PDGFRB CD80 TNRC6C DUSP10 PIP5K1B SPTBN4 NRG1 TNRC6A CHUK ADCY5 FGF22 PSME2 PSMB8 NRG2 CUL3 PSMD13 PSMA2 PSMB3 DUSP6 ERBB4 MET FGA PTK2 TSC2 SPTB NRAS SPRED3 TNRC6B FOXO3 GSK3A FGF1 IL3RA IL2RA PIP5K1A PPP2CB IL5RA PSMB9 EPN1 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E PTPN3 FOXO4 PSMC3 PSMA6 ARHGEF7 FGF2 AL358075.4 ICOS BTC PXN IL2RB RAPGEF2 CDKN1A ADCY2 RASGRP3 INSR BRAP IER3 SPRY1 SHC3 CD28 PEBP1 IL5 YWHAB FYN GRIN2D UBB FGF16 AGO4 STAM IL2RG FGF5 PSMC6 IRS1 ARRB2 PPP2R1B MARK3 RAP1A PSMA1 MAPK3 PDGFRA CAMK2A GSK3B GFRA2 VCL ITPR1 ERBB2 GRB2 GRIN1 LAT RAF1 SPTA1 PIP4K2B RANBP9 INS-IGF2 FRS3 DLG4 SH3GL1 FGFR2 PPP2R5D NCAM1 SH3GL2 CNKSR2 PSMB5 RASGRP4 PSMD12 PTPN12 TP53 NRG4 WDR83 MAP2K1 MOV10 PRKACB NRG3 PIP5K1C CALM2 UBA52 PTEN PSMD7 PSMD11 GFRA3 PSPN AGO2 RASGRP1 HGF INS PSME3 PEA15 JAK3 SPTBN5 ADCY8 PSMD6 ACTN2 DUSP1 MAP3K11 PPP2R5A DUSP9 AL672043.1 RPS27A ADAM17 CSF2RB RASAL2 CALM1 PIK3R3 FRS2 ADCY9 PRKAR1A RASAL1 PIK3R2 FGF4 PIP4K2C PDGFA FGF7 PRR5 EREG SOS1 PPP2R5B DUSP8 PRKACA EPS15L1 RASA1 PSMA5 DUSP4 PRKCA CSF2 ADCY7 DUSP16 PSMD2 ARAF PAG1 PDGFB NEFL FGFR3 PSMA8 TRAT1 MIR26A2 PSMB10 PTPN11 AGO3 FGF23 GAB1 LCK MAPK1 PRKAR2A ADCY6 MIR26A1 SPTAN1 SPRED1 CDC42 ITPR3 PDPK1 PSMB11 RET FGG PSMD8 KBTBD7 GFRA1 FOXO1 AHCYL1 PIK3R1 JAK2 RASGEF1A FGF20 MTOR GRIN2B PDE1C ITGB3 PSMC5 NR4A1 AGO1 BRAF AKT3 PIP4K2A PSMD4 TRIB3 RASA3 MDM2 PSMA4 STAM2 DAB2IP SPTBN2 PSMB4 DUSP5 PHLPP1 CAMK4 KLB FGF8 AKT2 GDNF CREB1 PPP2CA SH3KBP1 PAQR3 FGF9 ITPR2 BAD SYNGAP1 APBB1IP RPS6KB2 SEM1 PPP5C AKT1S1 PLCG1 PSMA7 PTPRK SHC1 PRKCG SPRY2 ARTN KITLG PSMA3 FGF17 ANGPT1 GRK2 AKAP9 -REAC:2559583 Cellular Senescence E2F3 MDM4 MDM2 HIST3H3 CDC27 CBX2 ACD CDK2 CBX8 KDM6B TNRC6B RAD50 ANAPC2 MAPKAPK3 MAPK7 AGO1 MIR24-2 HIST1H4H CDC23 HIST2H4B RPS6KA3 TXN HIST3H2BB RNF2 MAP2K3 UBE2E1 CDKN1A HIST1H1C RPS6KA2 HIST1H2BA CCNE2 HIST1H2BC HIST1H2AB POT1 MAP2K4 H2AFB1 HIST1H2BE CDKN1B RB1 HIST2H3C HIST1H3E ANAPC7 HIRA ANAPC10 HIST1H4I HIST1H3A H2AFX PHC3 HIST1H4F H2AFZ UBE2D1 HIST1H1B TERF1 CEBPB HIST2H2AC HIST1H2AD MAP2K7 ANAPC15 HIST2H2AA4 FZR1 ATM HIST1H1E MRE11 RPS6KA1 TFDP2 HIST1H2BD HIST1H3J HIST1H1A HIST1H2BB HMGA2 CDK6 CDC16 HIST1H3F IFNB1 HIST1H2AC CDKN2B PHC1 ANAPC16 EHMT1 CABIN1 ETS1 TNRC6A BMI1 MAPK1 H2BFS CDKN2C HIST1H2BN HIST1H3C EHMT2 HIST1H2AE E2F1 AGO3 ANAPC5 TNRC6C H3F3B RELA H2AFV HIST2H3A HIST1H4K HMGA1 CDKN2A STAT3 CDC26 KAT5 EP400 HIST1H2BI UBA52 CDK4 MAPK14 HIST1H1D UBC LMNB1 HIST1H3H HIST1H2AJ MOV10 TP53 UBN1 HIST1H3B ANAPC1 TFDP1 HIST1H4D IL6 ASF1A FOS MAPK11 MAPKAPK5 NBN MIR24-1 ETS2 MAP4K4 MAPK10 TERF2 HIST1H2BO RPS27A CDKN2D CBX6 H2AFJ HIST2H4A HIST1H2BF CCNA2 HIST1H4A MAPK9 MAPK8 HIST2H2BE HIST1H2BG HIST4H4 HIST1H4B ID1 IGFBP7 EZH2 CCNE1 CCNA1 RBBP4 CBX4 MAP3K5 ERF UBE2C MINK1 H1F0 AGO4 HIST1H4L UBB EED TNIK TINF2 HIST1H2BJ HIST1H2BH H3F3A RING1 HIST1H3D E2F2 HIST2H3D HIST1H3I ANAPC11 ANAPC4 MAPKAPK2 JUN IL1A NFKB1 CXCL8 HIST1H2BK TERF2IP HIST1H3G PHC2 HIST1H4E RBBP7 HIST2H2AA3 HIST1H4C SP1 SCMH1 HIST1H2BL HIST1H2BM HIST1H4J MAP2K6 SUZ12 MAPK3 -REAC:180292 GAB1 signalosome SRC PPP2R5D FGFR2 MOV10 KIT NRG4 TP53 PIK3CA PTEN PIP5K1C NRG3 CSK PHLPP2 INS AGO2 HGF CD19 PIK3CD IRS2 AKT1 AL672043.1 PPP2R5A FGFR4 KL FRS2 PIK3R3 EGFR MLST8 CD28 INSR IER3 FGF5 AGO4 FGF16 THEM4 FYN IRS1 EGF FGF10 PPP2R1B RICTOR GSK3B PDGFRA MAPK3 CASP9 GRB2 ERBB2 PIP4K2B MAPKAP1 PPP2R1A FGF6 CD86 INS-IGF2 NR4A1 MET ERBB4 MTOR TSC2 AGO1 FOXO3 TRIB3 PIP4K2A TNRC6B AKT3 PIP5K1A FGF1 GSK3A MDM2 FGF8 AKT2 CREB1 PPP2CA KLB PPP2CB PHLPP1 FOXO4 PIK3AP1 PPP2R5E BAD FGF9 CDKN1B PXN BTC ICOS AL358075.4 AKT1S1 FGF2 RPS6KB2 FGF17 CDKN1A KITLG PIP4K2C FGF7 PDGFA PIK3R2 FGF4 FGF18 PIK3CB FGFR1 PPP2R5B FGF19 EREG PRR5 FGF3 HBEGF ERBB3 VAV1 PPP2R5C FGFR3 CD80 TNRC6C PDGFRB PAG1 PDGFB MAPK1 NRG1 LCK GAB1 FGF23 PIP5K1B AGO3 PTPN11 TRAT1 MIR26A2 PDPK1 TNRC6A MIR26A1 FGF20 NRG2 PIK3R1 FOXO1 FGF22 CHUK -REAC:2262752 Cellular responses to stress HIST1H4E WIPI2 ATG4B MRPL18 DCTN2 PRDX5 RBBP7 RRAGA VEGFA HSP90AB1 ANAPC11 NFKB1 ATG14 WTIP LAMTOR1 CAMK2A NUDT2 GSK3B HIST1H2BM PSMA1 MAP2K6 HSPA4 PIK3R4 CHMP4A MAPK3 RPS19BP1 TXNRD1 ATG9A SLC38A9 PSMC6 RPA2 HIST1H4B EZH2 PRKAB1 HIST1H2BJ HSPA1B TINF2 HSF1 RING1 HIST1H3I EGLN1 HIST1H3D CYBB EED UBB AGO4 MAPKAPK5 ETS2 TERF2 MAPK10 MAP4K4 HIF1A CHMP4C RRAGB PRKAG3 NUP88 FKBP4 GSTP1 MAPK9 ERO1A PSMD6 MAPK8 HIGD1A HIST1H2BO ATOX1 RPS27A CDKN2D SOD2 SOD1 HIST1H2BI DCTN4 DYNC1H1 EP400 UBA52 STIP1 CDK4 HSPA5 BAG5 HIST1H1D VCP PRDX2 PSME3 CDKN2A PRKAA1 ATG4D HSPA14 NOX5 STAT3 PSMD7 PSMD11 ANAPC1 TFDP1 HIST1H3B IL6 ASF1A NUP153 LMNB1 MOV10 CCAR2 AMBRA1 HIST1H2AJ ATG101 PSMD12 PSMB5 TP53 GML EHMT1 NUP62 PSMB11 ANAPC16 PSMD8 CABIN1 HIF3A CDK6 LIMD1 HMGA2 FKBPL EGLN3 NUP133 RPA3 HIST1H2AC UVRAG GPX3 PGR ATG4C PHC1 PSMA8 ANAPC5 H2AFV HIST2H3A RELA NUP37 PSMD2 CHMP7 NUP35 BMI1 BAG4 ATG9B MAPK1 HIST1H2BN E2F1 PSMB10 AGO3 HIST1H2AE HIST1H3C HIST1H4F PHC3 PSMA5 CHMP4B HIST1H1B UBE2D1 UBE2D2 TERF1 VHL HIRA POM121C HIST1H4I AAAS NDC1 CAT HIST1H1E TFDP2 HIST1H3J HIST1H1A EGLN2 DNAJC2 CEBPB MAP2K7 EPAS1 ELOB CCNE2 DNAJB1 PSMA7 SEM1 HSPA4L DNAJA2 AKT1S1 NR3C1 RAE1 PSMA3 HIST1H1C RPA1 NUP107 HIST2H3C HIST1H3E NUP43 HSPA12B LAMTOR4 MAP2K4 DCTN1 PRKAB2 HSPA2 NUP58 GPX1 HSPB2 BAG1 AR RRAGC ULK1 RAD50 PSMD4 E2F3 HIKESHI PSMB4 MDM4 NUP50 HSBP1 NUP214 P4HB MDM2 PSMA4 DEDD2 BECN1 HSPA7 CDC27 ATG10 PSMC5 HIST2H4B CHMP6 NUP210 MTOR HIST3H2BB GPX2 CHMP3 MAPK7 AGO1 MIR24-2 PHC2 HIST1H3G ATG5 ARNT LAMTOR5 PSMB6 GABARAPL2 WIPI1 ANAPC4 MAPKAPK2 IL1A PSMB7 JUN CXCL8 EEF1A1 MAP1LC3A TERF2IP HIST1H2BK PSMD1 SOD3 SCMH1 HIST1H2BL SUZ12 CYCS HIST1H4J HIST2H2AA3 CAMK2G HIST1H4C CHMP2A BAG3 DYNC1LI2 SP1 PSMD10 MAP3K5 CBX4 ERF CA9 PSMC2 UBE2C HDAC6 PSME4 DYNLL2 PRKAG1 HIST4H4 ATG12 DCTN5 ID1 CCNA1 CCNE1 RBBP4 IGFBP7 PSMC4 RPTOR TNIK PRDX3 MLST8 CREBBP H3F3A HIST1H2BH CUL2 HIST2H3D EPO EP300 E2F2 MINK1 H1F0 MAP1LC3C BAG2 NCF1 MAP1LC3B PRKAG2 SIRT1 HSPA1A RRAGD LAMTOR2 NUP54 HIST1H4L DYNC1I2 MIR24-1 NBN PSMD9 PSMB2 FOS MAPK11 NOX4 AQP8 WDR45 CRYBA4 GPX5 HIST2H2BE HSP90AA1 COL4A6 HIST1H2BG ATP7A PSMB1 CBX6 HIST1H2BF CCNA2 HIST1H4A H2AFJ HIST2H4A DCTN3 RB1CC1 NUP160 TPR UBC MAPK14 HMGA1 DYNC1LI1 GABARAPL3 LAMTOR3 MTMR3 KAT5 CDC26 PRDX6 HIST1H4D CAMK2D PRKAA2 ATG7 GPX7 HIST1H3H HSPA6 DNAJA4 PIK3C3 TNFRSF21 CAMK2B UBN1 GSR ETS1 ST13 TNRC6A DYNC1I1 HIST1H3F PSMB8 CDC16 HIST1H2BB POM121 HSPA1L IFNB1 UBE2D3 PSMA2 PSMD13 PSMB3 HSPA13 RANBP2 PSME2 CDKN2B H3F3B TNRC6C YWHAE CITED2 GABARAPL1 PSMD14 PSMC1 HIST1H4K NR3C2 CDKN2C H2BFS HSPA12A TSC1 EHMT2 ATG4A H2AFZ MTMR14 H2AFX PSMD3 GPX6 PSME1 NUPL2 ANAPC10 DNAJC7 GPX8 HIST1H3A FZR1 RBX1 HIST1H2BD DCTN6 RPS6KA1 NUP85 MRE11 ATM NUP205 AC010132.3 HSPA9 HIST2H2AC FKBP5 NUP155 HIST1H2AD ANAPC15 PSMD5 HIST2H2AA4 SEH1L HIST1H2AB HIST1H2BC HIST1H2BA NCF4 POT1 ATR PTGES3 SERPINH1 ATG3 DNAJA1 CHMP2B AJUBA CDKN1A UBE2E1 MAP2K3 RPS6KA2 HIF1AN TXN2 NUP98 ANAPC7 PSMB9 ATG13 DYNLL1 HSPA8 H2AFB1 RHEB PSMC3 PSMA6 HSPH1 RLN1 CDKN1B HIST1H2BE PSMF1 ELOC RB1 NCF2 ATG16L1 CDK2 CCS CBX8 KDM6B TNRC6B TXNRD2 NUP188 HIST3H3 HSPB1 CBX2 ACD CDC23 RPS6KA3 TXN PRDX1 RNF2 NUP93 CYBA MAPKAPK3 ANAPC2 GABARAP DNAJB6 WDR45B TSC2 HIST1H4H -REAC:198203 PI3K/AKT activation MTOR ERBB4 MET NR4A1 TSC2 AGO1 AKT3 PIP4K2A TNRC6B TRIB3 FOXO3 MDM2 GSK3A FGF1 PIP5K1A PPP2CB PHLPP1 KLB FGF8 PPP2CA CREB1 AKT2 CDKN1B BAD FGF9 PPP2R5E PIK3AP1 FOXO4 RPS6KB2 FGF2 AL358075.4 AKT1S1 ICOS BTC KITLG CDKN1A FGF17 PIK3CB FGF18 PIK3R2 FGF4 FGF7 PDGFA PIP4K2C PRR5 EREG FGF19 PPP2R5B FGFR1 VAV1 ERBB3 HBEGF FGF3 NTRK1 PPP2R5C PDGFB PDGFRB CD80 TNRC6C FGFR3 TRAT1 MIR26A2 PIP5K1B PTPN11 AGO3 FGF23 GAB1 LCK NRG1 MAPK1 MIR26A1 TNRC6A PDPK1 CHUK FGF22 FOXO1 PIK3R1 NRG2 FGF20 FGFR2 PPP2R5D SRC PIK3CA TP53 NRG4 MOV10 KIT NRG3 PIP5K1C PTEN CD19 HGF AGO2 INS PHLPP2 IRS2 NGF PIK3CD FGFR4 RHOA PPP2R5A AL672043.1 AKT1 KL EGFR PIK3R3 FRS2 IER3 INSR CD28 MLST8 FYN FGF16 THEM4 AGO4 FGF5 IRS1 PPP2R1B FGF10 EGF MAPK3 PDGFRA GSK3B RICTOR ERBB2 CASP9 GRB2 FGF6 PPP2R1A MAPKAP1 PIP4K2B INS-IGF2 CD86 -REAC:1257604 PIP3 activates AKT signaling MTOR ERBB4 NR4A1 MET TSC2 AGO1 AKT3 PIP4K2A TNRC6B TRIB3 FOXO3 GSK3A MDM2 FGF1 PIP5K1A PHLPP1 PPP2CB KLB PPP2CA FGF8 CREB1 AKT2 CDKN1B BAD FGF9 PPP2R5E PIK3AP1 FOXO4 RPS6KB2 AKT1S1 AL358075.4 FGF2 ICOS BTC CDKN1A KITLG FGF17 PIK3CB PIK3R2 FGF4 FGF18 PIP4K2C FGF7 PDGFA PRR5 EREG PPP2R5B FGF19 FGFR1 VAV1 ERBB3 HBEGF FGF3 PPP2R5C PDGFRB PDGFB TNRC6C CD80 FGFR3 MIR26A2 TRAT1 FGF23 AGO3 PTPN11 PIP5K1B GAB1 MAPK1 LCK NRG1 TNRC6A MIR26A1 PDPK1 FGF22 CHUK FOXO1 NRG2 PIK3R1 FGF20 FGFR2 PPP2R5D SRC PIK3CA TP53 NRG4 MOV10 KIT PIP5K1C NRG3 PTEN CD19 INS HGF AGO2 PHLPP2 IRS2 PIK3CD FGFR4 PPP2R5A AKT1 AL672043.1 KL PIK3R3 EGFR FRS2 IER3 INSR MLST8 CD28 FYN AGO4 FGF16 THEM4 FGF5 IRS1 PPP2R1B FGF10 EGF MAPK3 GSK3B PDGFRA RICTOR ERBB2 CASP9 GRB2 PPP2R1A FGF6 MAPKAP1 PIP4K2B INS-IGF2 CD86 -REAC:212436 Generic Transcription Pathway ZNF776 ZNF736 ZNF700 CHM ZNF658B TP53AIP1 CASP10 RARG ZNF235 HUS1 ZNF200 ZNF17 ZNF664 RRM2B TFAP2C ZNF786 PSMB1 ZNF737 TAF5 NDUFA4 COX6B1 TOM1L1 ZNF493 ZNF649 NBN ZNF557 RFC5 POLR2I ZNF213 PRMT5 ZNF600 ZNF418 ZNF671 MAPK11 ZNF426 SRC TAF11 GTF2H4 BTG2 ZNF655 KIT ERCC2 ZNF677 ZNF709 ZNF234 ATAD2 SCO1 TAF9B ZNF28 ZNF691 MAPK14 ZNF584 ZNF317 CTGF ZNF445 ZNF492 ZNF771 KAT5 ZNF558 BCL6 TEAD3 TBL1X ZIM3 TAF7L ZNF157 ZNF136 ZNF415 ZNF792 BLM PSMD1 STK11 RICTOR NELFCD DDB2 ZNF446 SP1 ZNF727 NOTCH2 RUNX3 TRAPPC2 LAMTOR5 ZNF460 ZNF331 PSMB6 NKX2-5 ZKSCAN5 PPP2R1A MAPKAP1 CITED1 ZNF554 DNA2 MED1 SMAD3 ZNF681 CASP2 JUN ZNF20 ZNF839 ZNF14 CTNNB1 EP300 PSMC4 ZNF189 L3MBTL1 NDRG1 MED15 SPP1 ZNF567 RORB ZNF483 PRKAG2 KDM5B ZNF12 CCNT1 NOC2L CGA TNKS1BP1 NR2F1 RXRB RMI1 RABGGTB ZNF705E MT-CO3 CCNA1 ZNF697 GLS WWTR1 ESRRA BCL2L11 KRBOX4 PPP2CB CCND1 ZNF112 ZNF740 ZNF10 NR2E1 ZNF486 SMARCD3 PSMB9 PIN1 PSMF1 ELOC GTF2H5 NR2C2AP PSMC3 MYBL2 ZNF223 PSMA6 ZNF41 RABGGTA POLR2B ZNF225 CHD3 ZNF75A KAT6A MED26 HNF4A CNOT4 CENPJ RUNX2 DEK ZNF23 TCEA1 MBD3 ZNF540 BARD1 ZNF595 NR5A1 ZNF343 TXN PRDX1 ZNF33A WWOX MED24 BRD2 TSC2 POLR2D ZNF440 RAD1 GATA4 CTDP1 ZNF479 ZNF347 ZNF619 ZNF749 CSNK2B ZNF211 CDK13 CDK2 PPM1A ZNF256 FOXO3 ZNF433 SMURF2 ZNF37A COX11 ZNF227 TFAP2D ZNF33B ZNF133 PSMD14 BRPF1 ESRRB ZNF577 USP2 ITGAL PCNA UBE2I CITED2 YWHAE IGFBP3 ZNF224 ZNF772 BCL2L14 ZNF555 TAF1 BRCA1 NR3C2 NOP2 ZNF547 ZNF729 RBL2 TNRC6A ZNF706 CASP6 PLAGL1 CSNK2A2 SKIL HDAC1 RXRG CDKN2B PSME2 PSMB8 SMURF1 PSMA2 UBE2D3 PSMD13 AC010132.3 AC003002.1 CNOT11 ZFP1 PMS2 ATM ZNF385A ZNF304 ERCC3 ZNF519 TAF10 ZNF597 POLR2J PSME1 SUPT4H1 THRB TAF4 MNAT1 PARP1 ZNF160 ZNF230 PLK2 ZNF333 NR2E3 MAML3 ZNF684 BANP CNOT7 BNIP3L ZNF773 ZNF202 ZNF425 CDK9 TCF7L2 ZNF692 ZNF710 ZSCAN25 ZNF180 ZNF670 ZNF510 GATAD2A MT-CO1 ZNF552 COX14 RPS27A BRPF3 NRBP1 MAPKAPK5 HDAC2 CDK1 ZNF568 ZNF221 GTF2F1 COX5B BRIP1 AURKB ZNF208 TFDP1 ZNF667 COX7A2L RGCC RAD9A BRD7 ZNF717 PSMD12 ZNF571 POLR2F ZNF614 MYC UBA52 PTEN MED6 SUPT16H PSMD7 NR1H3 PRDX2 PSME3 CDKN2A PRKAA1 ZNF155 COX16 ATRIP SMAD2 ZFP14 NR5A2 ZNF468 ZNF607 GATAD2B RBBP7 PRDX5 RRAGA ZNF680 NUAK1 SMAD4 VEGFA ZNF471 NCOR1 ZNF79 TCF7 RXRA COX19 NPPA GTF2H3 RNF34 ZNF613 ING2 UBB AGO4 CSNK2A1 MED10 CITED4 ZNF778 ZNF282 PPARA CDK5 ZNF429 ZKSCAN1 PRKAB1 ELOA ZNF138 TMEM219 ZNF70 ZNF431 RPA2 ZNF26 SCO2 CCNH TRIM28 RARA ZKSCAN8 RUNX1 GLS2 ZNF735 PPP2CA ZNF543 RAD51D ZNF582 APAF1 ZNF720 ZNF782 EXO1 LAMTOR4 NR1H4 KCTD15 ZFP28 CNOT2 CCNE2 PSMA7 TGS1 RPA1 ZNF19 NR3C1 PSMA3 ZNF337 TP53BP2 ZNF586 ZSCAN32 SURF1 MTOR COX18 POLR2G SESN3 CNOT6 GTF2H1 PSMC5 ZNF714 NR4A1 AGO1 ZNF716 CNOT6L ZNF154 ZNF92 THRA ZNF775 RAD50 AR PSMD4 TBX5 BRD1 ZNF490 ZNF324B ZNF263 MAML2 ZNF212 PSMA4 E2F7 MED17 TAF4B MED27 POU4F1 ZNF254 PSMB4 ZNF18 ZIM2 ZIK1 ZNF790 ZNF641 TGIF1 ELOA3D ELOA3B CHD4 CRADD HELZ2 ZNF222 COX8A AGO3 RBBP8 ZNF561 ELL ZNF302 MDC1 MEN1 RORC HKR1 PDPK1 KAT2B PMAIP1 ZNF589 ZNF585A MED7 PRELID1 E2F5 NOTCH3 ZNF544 ZNF257 SMYD2 ZNF248 NR1H2 TFDP2 PIP4K2C ZNF267 ELOB TNFRSF10C PRMT1 ELOA2 CCNT2 ZNF253 YY1 TMEM55B ZNF573 ZNF559 TP53I3 ZNF724 NEDD4L ZFHX3 ZNF702P NRBF2 ZNF436 JAG1 ZNF443 ESRRG NR2F6 ZNF761 JUNB FANCC MEAF6 LEF1 ZNF514 NLRC4 CCNA2 ESR2 ZNF34 RBL1 ZNF606 CCNB1 BBC3 AKT1 TNFRSF10B POLR2E VDR ITGA4 ZNF668 MED13 SMAD7 ZNF682 ZNF774 CDK12 PSMD9 PSMB2 ZNF688 EGFR ZNF675 NR2C2 ZNF662 PIDD1 ZNF141 FOS ZNF777 PRKAA2 ZNF564 MED20 ZNF3 ZNF484 KRAS MED25 ZNF99 SUPT5H ZNF430 ZNF268 ZNF570 RFFL NR6A1 DYRK2 ZNF135 CASP1 UBC BAX WRN PLK3 LAMTOR3 TAF7 ZNF214 PITX2 ATP1B4 RAD17 ZNF708 CYCS NOTCH4 TAF3 ZNF705A COX20 POLR2A PHF20 CDK5R1 TAF12 ZNF383 PSMD10 ZNF703 ZNF705D ZKSCAN4 ZNF611 ZNF419 CGB8 ZNF197 HDAC4 TFAP2A CNOT8 POLR2L TRIM33 COX7C ZNF620 ZNF665 ZNF454 ZNF799 KMT5A AC002310.5 PSMB7 POU4F2 TGIF2 TBL1XR1 RPTOR TBP ZNF354C RARB CREBBP MLST8 ZNF77 ZNF566 RRAGD LAMTOR2 TACO1 TP63 FANCI CNOT3 ZNF626 PSMC2 COX6A1 CHEK2 CBFB ZFP37 ZNF287 ZNF718 DAXX RBBP4 CCNE1 NCOA1 TRIAP1 ZNF615 PRKAG1 PRDM7 NR1D1 GADD45A RAD9B TAF13 ZNF730 ZNF610 E2F4 ZNF721 CDC25C ZNF517 HSPD1 CDKN1B MED16 CCNK RHEB NCOA6 ATR ZNF300 ZNF770 MT-CO2 CGB5 ZNF696 MAMLD1 ZNF750 NR4A3 ZNF658 CDKN1A ZNF528 AURKA YAP1 MAML1 ZNF195 TEAD4 ZNF689 NOTCH1 CNOT1 RBPJ PERP ZNF599 ZNF556 NR1I3 ZNF205 ZNF439 CNOT10 AIFM2 ZNF506 ZNF669 PRDM1 ZNF266 NR0B2 ZNF100 COX4I1 YWHAZ TNRC6B ZNF746 YWHAH POLR2K ZNF624 ZNF184 ZNF548 ESR1 PRELID3A TCF7L1 ZFP69B PSMC1 GPI TNRC6C STEAP3 ZNF676 TSC1 MED14 EHMT2 YWHAQ ZNF114 ING5 TP53INP1 CCNG1 TIGAR ZNF530 GSR SETD9 ZNF804B ZNF747 ZNF354B ZNF678 PSMB3 YEATS4 PPP1R13L ZNF273 MRE11 ZNF587 G6PD ZNF585B PSMD5 NELFB ZNF75D NR1D2 ZNF101 ZNF699 ZNF473 TEAD1 ZNF660 ZNF767P PPP1R13B ZNF398 ZNF442 ZNF565 ZNF563 SERPINE1 PSMD3 CCNC SSRP1 ZNF350 COX7B ZNF711 ZNF285 PPP2R5C ZNF286A ZNF704 ZNF500 ZNF461 FANCD2 PPARG TNFRSF10D PSMD6 ZNF860 KCTD1 ZNF416 RHNO1 CARM1 SNW1 ZNF562 NR1I2 ZNF394 SESN1 ZNF583 CHEK1 LRPPRC ZNF264 CDK7 TPX2 ELOA3 NCOR2 PPARD PRKAG3 BID ZNF549 ZNF785 RRAGB KRBA1 TEAD2 MSH2 COX6C ZNF840P HES1 ZNF71 PSMB5 TP53 ZNF334 MOV10 HIPK1 ZNF529 ZNF354A TFAP2B ZNF485 MED4 HNF4G PSMD11 ZNF726 AGO2 ZNF43 MAP2K6 PSMA1 TP73 TXNRD1 LAMTOR1 AC134772.2 BIRC5 POLR2H COX5A ERBB2 JMY ZNF124 TAF1L TP53RK MTA2 ZNF791 MED30 NPM1 ZNF605 PIP4K2B ZFP30 ZNF496 ZNF226 RFC2 NELFE ZNF480 MED23 HIPK2 YWHAB MLH1 SLC38A9 PSMC6 TAF2 ZKSCAN7 ZNF30 TTC5 PCBP4 GTF2H2 PPP2R1B ZFP69 TOP3A TOPBP1 ZNF233 CDK8 USP9X ZNF546 ZNF701 CHD9 ZNF324 ZKSCAN3 AKT2 ZNF215 ARID3A PRKAB2 MED8 RMI2 ZNF793 ZNF732 ZNF74 ZNF738 MED31 SEM1 NELFA ZNF560 ZNF627 ZNF25 ZFP90 ZNF551 TNFRSF10A SUMO1 ZNF596 NR0B1 GPX2 ZNF311 APOE RFC4 NCOA2 ZNF705G E2F8 USP7 GTF2F2 ZNF250 AKT3 NR2C1 MED12 PML RRAGC ZNF713 PIP4K2A ZNF616 ZNF274 RORA ZNF569 CNOT9 RNF111 TGFB1 ZNF2 MDM2 ATF2 SFN MDM4 ZNF432 PSMD2 ZFP2 FAS MIR26A2 PSMB10 POLR2C E2F1 TAF9 ZNF621 TAF6 MIR26A1 CGB3 ZNF420 EHMT1 TGFA PSMD8 RPA3 ZNF625 PGR SGK1 KAT2A ZNF764 ZNF382 ZNF707 ZNF45 RFC3 TFAP2E SESN2 NR4A2 ZNF320 PRR5 ZNF470 ZNF140 ZNF441 SKI UBE2D1 ZNF175 DDIT4 ZNF679 PSMA5 YWHAG ZNF169 ZNF417 ZNF550 -REAC:186797 Signaling by PDGF KRAS CAMK2D SRC KIT CSF2RA RAPGEF1 NRTN COL9A2 PIK3CA IL2 CAMK2B RASA4 SPTBN1 UBC CSK PHLPP2 LAMTOR3 DUSP2 CD19 ADCY4 IRS2 VWF PIK3CD PDE1B GRIN2A PHB IQGAP1 PSMB1 AKT1 PRKAR1B PTPRA FGFR4 PSMD9 PSMB2 PRKCD KL MAP2K2 STAT5A PRKAR2B EGFR PSMC4 HRAS TLN1 SPP1 MLST8 ADCY3 CALM3 RASGRF1 DUSP7 LAMTOR2 THEM4 ADCY1 GRB7 JAK1 COL4A1 PSMC2 RAP1B KSR1 COL6A5 PSME4 EGF SPRED2 PDE1A FGF10 COL4A3 TEK PSMD1 RICTOR COL6A2 GFRA4 CASP9 CAMK2G PSMD10 IL3 MAPKAP1 THBS3 RASAL3 FGF6 PSMB6 PPP2R1A GRIN2C RASGRF2 CD86 PSMB7 CNKSR1 FGA MET PTK2 DUSP6 ERBB4 SPTB NRAS STAT5B TSC2 FOXO3 COL6A6 SPRED3 TNRC6B FGF1 IL3RA IL2RA PIP5K1A GSK3A PSMB9 PPP2CB IL5RA FOXO4 PSMA6 PSMC3 NCK1 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E ICOS BTC IL2RB FGF2 AL358075.4 RAPGEF2 CDKN1A ADCY2 RBX1 FN1 SHC2 AC010132.3 PIK3CB PRKCE FGF18 FGF19 ARRB1 FGFR1 PRKACG NF1 PSMD5 ERBB3 HBEGF ITGA2B PSMD3 FGF3 FGB PSME1 VAV1 PPP2R5C KSR2 TNRC6C CD80 IL17RD PSMD14 PSMC1 PDGFRB NRG1 DUSP10 PIP5K1B SPTBN4 TNRC6A PSMB8 CUL3 NRG2 PSMA2 PSMB3 PSMD13 CHUK FGF22 ADCY5 PSME2 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 NRG4 WDR83 MAP2K1 MOV10 PRKACB FURIN PSMB5 PSMD12 RASGRP4 PTPN12 TP53 CALM2 UBA52 THBS2 PTEN NRG3 PIP5K1C PDGFD HGF RASGRP1 AGO2 INS PSME3 STAT3 PLG PSMD7 PSMD11 PSPN GFRA3 SPTBN5 JAK3 ADCY8 PSMD6 PEA15 DUSP9 AL672043.1 RPS27A CSF2RB ACTN2 DUSP1 MAP3K11 PPP2R5A CALM1 RASAL2 ADCY9 PRKAR1A PIK3R3 FRS2 CD28 PEBP1 RASGRP3 THBS1 BRAP INSR IER3 SHC3 IL2RG FGF5 YWHAB IL5 GRIN2D FYN FGF16 COL4A2 UBB AGO4 IRS1 PSMC6 RAP1A ARRB2 PPP2R1B MARK3 PDGFRA CAMK2A GSK3B GFRA2 COL4A4 VCL PSMA1 MAPK3 GRB2 GRIN1 LAT COL6A3 ITPR1 ERBB2 SPTA1 PIP4K2B RANBP9 STAT1 RAF1 INS-IGF2 FRS3 GRIN2B PDE1C PSMC5 ITGB3 NR4A1 MTOR COL9A1 BRAF AGO1 TRIB3 COL6A1 RASA3 AKT3 PSMD4 PIP4K2A DAB2IP SPTBN2 PSMB4 COL9A3 DUSP5 MDM2 PSMA4 KLB GDNF FGF8 AKT2 CREB1 PPP2CA PHLPP1 CAMK4 APBB1IP CRK PAQR3 ITPR2 FGF9 BAD SYNGAP1 PLCG1 PSMA7 RPS6KB2 PDGFC SEM1 PPP5C AKT1S1 KITLG PSMA3 FGF17 AKAP9 ANGPT1 GRK2 SHC1 NCK2 PRKCG PLAT ARTN PIP4K2C PDGFA FGF7 RASAL1 PIK3R2 FGF4 SOS1 PPP2R5B DUSP8 PRR5 EREG COL4A5 PSMA5 DUSP4 PRKACA RASA1 STAT6 CSF2 ADCY7 DUSP16 PRKCA THBS4 BCAR1 NEFL FGFR3 PSMA8 PSMD2 CRKL ARAF PDGFB GAB1 LCK PRKAR2A MAPK1 MIR26A2 TRAT1 AGO3 FGF23 PTPN11 PSMB10 PDPK1 ITPR3 PSMB11 FGG RET PSMD8 KBTBD7 ADCY6 MIR26A1 SPRED1 SPTAN1 PIK3R1 JAK2 RASGEF1A FGF20 GFRA1 FOXO1 AHCYL1 -REAC:3214842 HDMs demethylate histones HIST1H4C KDM6A KDM4C HIST1H4A KDM2B HIST1H3C HIST2H4A KDM5D HIST2H3A HIST1H3E JMJD6 HIST2H3C HIST1H4K HIST1H4J ARID5B HIST1H3F RIOX2 PHF2 KDM4B KDM3A HIST1H3G KDM5C HIST1H4E KDM1A HIST1H3H KDM1B UTY HIST1H4H HIST1H4L KDM7A KDM5B KDM4A HIST1H4D HIST2H4B HIST1H3B HIST1H3I HIST2H3D KDM4D HIST1H3D HIST1H3J HIST4H4 KDM3B KDM8 KDM2A HIST1H3A KDM5A HIST1H4I HIST1H4B KDM6B HIST1H4F PHF8 -REAC:1236394 Signaling by ERBB4 DUSP6 ERBB4 WWOX SH2B1 PTK2 FGA MET APH1A TSC2 NRAS SPTB STAT5B TNRC6B SPRED3 FOXO3 GSK3A ESR1 FGF1 IL3RA PIP5K1A IL2RA PPP2CB IL5RA PSMB9 RASA2 CDKN1B PSMF1 PPP2R5E PIK3AP1 FOXO4 PSMA6 PSMC3 FGF2 AL358075.4 ICOS BTC IL2RB CDKN1A RAPGEF2 YAP1 PIK3CB AC010132.3 FGF18 RBX1 FN1 SHC2 PSMD5 FGF19 ARRB1 FGFR1 NF1 FGB PSME1 VAV1 ERBB3 HBEGF ITGA2B PSMD3 FGF3 KSR2 PPP2R5C PSENEN IL17RD PSMD14 PSMC1 PDGFRB TNRC6C CD80 DUSP10 PIP5K1B SPTBN4 NRG1 CSN2 TNRC6A CHUK FGF22 PSME2 PSMB8 NRG2 CUL3 PSMA2 PSMB3 PSMD13 KRAS SRC CAMK2D NRTN PIK3CA CAMK2B IL2 KIT PRLR CSF2RA GFAP UBC CSK RASA4 SPTBN1 LAMTOR3 DUSP2 CD19 PHLPP2 GRIN2A IRS2 VWF PIK3CD FGFR4 PHB PSMB1 IQGAP1 PTPRA AKT1 GHR KL PSMD9 PSMB2 EGFR MAP2K2 BTRC STAT5A HRAS PSMC4 TLN1 MLST8 LAMTOR2 THEM4 CALM3 RASGRF1 DUSP7 PSMC2 RAP1B KSR1 JAK1 SPRED2 FGF10 PSME4 EGF GFRA4 S100B PSMD1 TEK PRL RICTOR PSMD10 CASP9 CAMK2G RASAL3 FGF6 PSMB6 PPP2R1A IL3 MAPKAP1 CNKSR1 GRIN2C RASGRF2 CD86 PSMB7 MTOR GRIN2B ITGB3 PSMC5 NR4A1 PSEN2 AGO1 BRAF AKT3 PIP4K2A PSMD4 TRIB3 RASA3 MDM2 PSMA4 DAB2IP SPTBN2 PSMB4 DUSP5 PHLPP1 KLB GDNF FGF8 PPP2CA AKT2 CREB1 PAQR3 BAD FGF9 SYNGAP1 APBB1IP RPS6KB2 SEM1 PPP5C AKT1S1 PSMA7 SHC1 ARTN KITLG PSMA3 FGF17 AKAP9 ANGPT1 RASAL1 PIK3R2 FGF4 PIP4K2C PDGFA FGF7 PRR5 EREG SOS1 ITCH PPP2R5B DUSP8 RASA1 PSMA5 DUSP4 CSF2 DUSP16 PSMD2 ARAF PDGFB NEFL PSMA8 FGFR3 TRAT1 MIR26A2 PTPN11 AGO3 FGF23 PSMB10 GAB1 LCK MAPK1 GH2 SPRED1 MIR26A1 SPTAN1 PDPK1 PSMB11 FGG PSMD8 RET KBTBD7 GFRA1 PGR FOXO1 PIK3R1 JAK2 NCSTN FGF20 RASGEF1A DLG4 FGFR2 PPP2R5D NCAM1 CNKSR2 RASGRP4 PSMB5 PSMD12 TP53 NRG4 WDR83 MAP2K1 MOV10 APH1B NRG3 PIP5K1C CALM2 UBA52 PTEN PSMD7 CXCL12 PSMD11 GFRA3 PSPN HGF RASGRP1 AGO2 INS PSME3 WWP1 PEA15 JAK3 SPTBN5 PSMD6 ACTN2 DUSP1 PPP2R5A CSH1 MAP3K11 DUSP9 AL672043.1 ADAM17 NEDD4 RPS27A CSF2RB RASAL2 CALM1 PIK3R3 FRS2 RASGRP3 INSR BRAP IER3 SHC3 CD28 PEBP1 IL5 YWHAB FYN GRIN2D UBB CUL1 FGF16 AGO4 IL2RG FGF5 PSMC6 IRS1 ARRB2 GH1 PPP2R1B MARK3 RAP1A PSMA1 MAPK3 CAMK2A PDGFRA GSK3B GFRA2 VCL ERBB2 GRB2 GRIN1 LAT RAF1 SPTA1 PIP4K2B RANBP9 SKP1 INS-IGF2 FRS3 TAB2 NCOR1 -REAC:449147 Signaling by Interleukins PSMD13 PSMA2 HIST1H3F TNIP2 PSMB8 IL25 PSME2 MUC1 CHUK FGF22 COL1A2 NRG1 CCL22 DUSP10 INPPL1 CD80 IL1R1 PSMD14 PDGFRB PTAFR IL17RD KSR2 MAOA IL11 FGF3 PSME1 VAV1 FGFR1 NF1 FGF19 SQSTM1 ALOX15 PIM1 HCK FGF18 AC010132.3 RAPGEF2 IL1B PTPN6 IL2RB IRAK2 LYN TAB1 TNFRSF1B PSMA6 PSMC3 OSM HSPA8 PSMF1 IL36A PSMB9 CCND1 NANOG IKBKG PPP2CB IL3RA FGF1 FCER2 FOXO3 PTGS2 SPRED3 STX3 SPTB MAPKAPK3 IL18 RPS6KA3 YES1 JUN CD86 GRIN2C IL17RA IL1RAP CXCL8 SYK IL3 PSMB6 MMP1 FGF6 PPP2R1A RASAL3 CAMK2G MEF2A LBP TEK VIM PSMD1 EGF SPRED2 IL33 KSR1 IL9 RIPK2 RAP1B RASGRF1 CALM3 DUSP7 TRAF6 CCL3L1 PSMC4 HIST2H3D BTRC MAPK11 TXLNA MMP9 TYK2 IL20RB PELI3 NOD2 IQGAP1 PSMB1 FSCN1 PTPRA ELK1 ITGAM FGFR4 VWF IRS2 GRIN2A HSP90AA1 TEC BCL6 IL7 DUSP2 RASA4 SPTBN1 UBE2V1 CSK MAPK14 CSF2RA KIT HIST1H3H CAMK2B ZEB1 CAMK2D SRC IL4R IL36B RASGEF1A PIK3R1 NDN GFRA1 IL17RE KBTBD7 RORC PSMB11 IL12A SPTAN1 IRAK4 IFNL3 PTPN11 FGF23 CSF1 IL1RL1 NEFL PELI2 IL17C VRK3 ARAF CSF2 DUSP4 STAT6 DUSP8 PPP2R5B EREG CXCL1 MAP2K7 FGF7 PDGFA NFKB2 CD36 MMP2 PIK3R2 IL19 FGF4 FGF17 ANGPT1 PSMA3 VCAM1 STX4 SHC1 OPRD1 PSMA7 PELI1 MCL1 PPP5C CRK PAQR3 PPP2CA CREB1 HIST1H3E GDNF HSP90B1 ITGAX PSMB4 IL16 PSMA4 RASA3 MEF2C IL17A PSMD4 MAPK7 CLCF1 PSMC5 ALOX5 GRIN2B TAB2 NFKB1 IL36G VEGFA FRS3 IL37 IL17RB SPTA1 IL32 IRAK3 RAF1 STAT1 IL12RB2 GRIN1 IGHG4 IL12B CCR2 PDGFRA PRTN3 MAPK3 BRWD1 ARRB2 RHOU IL6R IL34 IL22 UBB POMC PEBP1 HIST1H3D SHC3 IGHG1 CASP3 HIF1A IL1RN PIK3R3 CALM1 CDK1 RASAL2 SOCS1 AL672043.1 IFNLR1 RPS27A IL23A DUSP9 DUSP1 MAP3K7 MAP3K8 PPP2R5A NOS2 CCL2 PSME3 RASGRP1 HGF GFRA3 PSPN STAT3 PSMD7 IFNL2 UBA52 SMARCA4 CALM2 MYC NRG3 CCL3 NRG4 IL10 RAG2 BCL2 RASGRP4 PSMD12 IL1F10 CNKSR2 IL31 IL17RC IL6 DLG4 FGFR2 PSMB3 NRG2 CUL3 ANXA1 HMOX1 IL15RA LAMA5 SPTBN4 F13A1 INPP5D PSMC1 IL10RB IL24 ITGB1 PPP2R5C HIST1H3A IL18RAP ERBB3 ITGA2B HBEGF PSMD3 FGB ARRB1 STX1A PSMD5 CSF3 RPS6KA1 IL1RL2 RBX1 SHC2 FN1 PIK3CB CCR1 RPS6KA2 CDKN1A TWIST1 MAP2K3 BTC FGF2 AL358075.4 FLT3LG OPRM1 PPP2R5E RASA2 IL5RA IL17F IL2RA LIF SOCS5 IL31RA CEBPD YWHAZ NRAS IL4 STAT5B GATA3 OSMR S1PR1 IL15 MET FGA PTK2 IL20RA ERBB4 TIMP1 DUSP6 CCL19 IL1A PSMB7 RASGRF2 MAPKAPK2 CNKSR1 HIST1H3G PSMD10 IL9R GFRA4 IL20 PSME4 FGF10 JAK1 CBL IL6ST BCL2L1 IL22RA1 PSMC2 FPR1 HAVCR2 LAMTOR2 HRAS TLN1 STAT5A MAP2K2 FOS EGFR PSMB2 PSMD9 MMP3 IL22RA2 IL23R KL EBI3 AKT1 PHB PIK3CD MYD88 IL27 JUNB RPS6KA5 LAMTOR3 IRF4 ICAM1 UBC LCN2 CCL4 CASP1 RAPGEF1 IL2 NRTN CNTFR PIK3CA KRAS JAK2 FGF20 CXCL10 FOXO1 RET FGG PSMD8 CD4 NOD1 SPRED1 LCK MAPK1 PSMB10 HIST1H3C HIST2H3A RELA PSMA8 FGFR3 PDGFB PSMD2 LGALS9 CRKL DUSP16 IFNL1 CCL11 PSMA5 RASA1 PRKACA SOS1 BATF RASAL1 HIST1H3J AKAP9 KITLG CRLF1 ARTN SOX2 ATF1 UBE2N BLNK SEM1 MAP2K4 APBB1IP SYNGAP1 IL27RA FGF9 FGF8 CNTF HIST2H3C KLB IL10RA CTF1 DUSP5 DAB2IP SPTBN2 TNFRSF1A ATF2 TGFB1 RORA BRAF FBXW11 ITGB3 IL12RB1 CCL20 SKP1 IL18R1 CSF1R RANBP9 IGHE LAT GRB2 ERBB2 GFRA2 BIRC5 VCL CAMK2A PSMA1 MAP2K6 CXCL2 RAP1A IL7R NFKBIA MARK3 MAP3K3 PPP2R1B IL11RA IRS1 IL1R2 IRAK1 IL13RA1 PSMC6 FGF5 IL2RG CUL1 FGF16 YWHAB IL36RN IL5 GRIN2D FYN FASLG IL18BP GAB2 HIST1H3I BRAP SAA1 RASGRP3 TAB3 FRS2 SOCS3 CCL5 TOLLIP MAPK10 CSF2RB LIFR PTK2B MAP3K11 IL13 ACTN2 SPTBN5 JAK3 MAPK8 PSMD6 MAPK9 PEA15 TNF FLT3 DUSP3 PSMD11 IL13RA2 CCR5 RAG1 IKBKB MAP2K1 ITGB2 WDR83 TP53 POU2F1 PSMB5 NCAM1 PPP2R5D HIST1H3B CSF3R -REAC:1433557 Signaling by SCF-KIT SPTBN5 JAK3 PSMD6 PEA15 DUSP9 AL672043.1 SOCS1 CSF2RB RPS27A ACTN2 DUSP1 MAP3K11 PPP2R5A CALM1 RASAL2 CHEK1 PIK3R3 FRS2 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 NRG4 WDR83 MAP2K1 MOV10 PSMB5 PSMD12 RASGRP4 TP53 CALM2 UBA52 PTEN NRG3 PIP5K1C HGF AGO2 RASGRP1 INS PSME3 STAT3 PSMD7 PSMD11 GFRA3 PSPN RNASE1 PDGFRA CAMK2A GSK3B GFRA2 VCL PSMA1 MAPK3 GRB2 GRIN1 LAT ERBB2 SPTA1 PIP4K2B RANBP9 STAT1 RAF1 INS-IGF2 FRS3 GAB2 CD28 PEBP1 RASGRP3 INSR IER3 BRAP SHC3 IL2RG FGF5 YWHAB IL5 FYN GRIN2D UBB FGF16 AGO4 IRS1 GRB10 PSMC6 SOCS6 RAP1A ARRB2 PPP2R1B MARK3 KLB CREB1 GDNF FGF8 AKT2 PPP2CA PHLPP1 APBB1IP PAQR3 BAD FGF9 SYNGAP1 PSMA7 RPS6KB2 CMA1 SEM1 AKT1S1 PPP5C KITLG PSMA3 FGF17 ANGPT1 AKAP9 SHC1 ARTN GRIN2B ITGB3 PSMC5 NR4A1 MTOR BRAF AGO1 TRIB3 RASA3 AKT3 PIP4K2A SH2B2 PSMD4 DAB2IP SPTBN2 PSMB4 DUSP5 MDM2 PSMA4 NEFL FGFR3 PSMA8 ARAF PSMD2 PDGFB GAB1 LCK MAPK1 MIR26A2 TRAT1 PSMB10 PTPN11 AGO3 FGF23 PDPK1 PSMB11 FGG PSMD8 RET KBTBD7 SPRED1 MIR26A1 SPTAN1 PIK3R1 FGF20 RASGEF1A JAK2 GFRA1 FOXO1 FGF7 PIP4K2C PDGFA RASAL1 PIK3R2 FGF4 GRAP2 SOS1 PPP2R5B DUSP8 PRR5 EREG PSMA5 DUSP4 RASA1 CSF2 DUSP16 PRKCA IRS2 VWF PIK3CD TEC GRIN2A PHB IQGAP1 PSMB1 PTPRA AKT1 FGFR4 PTPRU PSMB2 PSMD9 KL MAP2K2 STAT5A EGFR MMP9 KRAS SRC CAMK2D KIT CSF2RA NRTN PIK3CA IL2 CAMK2B RASA4 SPTBN1 CSK UBC PHLPP2 LAMTOR3 CD19 DUSP2 TEK PSMD1 RICTOR GFRA4 CASP9 CAMK2G FER PSMD10 IL3 MAPKAP1 RASAL3 FGF6 PSMB6 FES PPP2R1A GRIN2C RASGRF2 PSMB7 CD86 GRAP CNKSR1 HRAS PSMC4 TLN1 MLST8 CALM3 RASGRF1 DUSP7 LAMTOR2 THEM4 CBL RAC1 GRB7 JAK1 PSMC2 RAP1B KSR1 PSME4 EGF SPRED2 FGF10 SH2B3 PSMB9 PPP2CB IL5RA FOXO4 PSMC3 PSMA6 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E LYN ICOS BTC IL2RB FGF2 AL358075.4 RAPGEF2 CDKN1A PTPN6 FGA MET PTK2 DUSP6 YES1 ERBB4 SPTB NRAS STAT5B TSC2 FOXO3 SPRED3 TNRC6B FGF1 IL3RA PIP5K1A IL2RA GSK3A CD80 TNRC6C IL17RD PSMD14 PSMC1 PDGFRB NRG1 DUSP10 PIP5K1B SPTBN4 TNRC6A PSMB8 NRG2 CUL3 PSMD13 PSMB3 PSMA2 CHUK FGF22 PSME2 RBX1 FN1 SHC2 PIK3CB AC010132.3 FGF18 FGF19 ARRB1 FGFR1 NF1 PSMD5 ERBB3 ITGA2B HBEGF PSMD3 FGF3 FGB VAV1 PSME1 PPP2R5C KSR2 -REAC:5654695 PI-3K cascade:FGFR2 GRB2 CASP9 ERBB2 PDGFRA GSK3B RICTOR MAPK3 INS-IGF2 CD86 MAPKAP1 PIP4K2B FGF6 PPP2R1A FGF5 FYN THEM4 FGF16 AGO4 CD28 MLST8 INSR IER3 EGF PPP2R1B FGF10 IRS1 AL672043.1 AKT1 FGFR4 PPP2R5A IRS2 PIK3CD EGFR PIK3R3 FRS2 KL NRG4 MOV10 KIT PIK3CA TP53 PPP2R5D SRC FGFR2 HGF AGO2 INS PHLPP2 CD19 PTEN NRG3 PIP5K1C GAB1 NRG1 LCK MAPK1 MIR26A2 TRAT1 AGO3 PIP5K1B PTPN11 FGF23 FGFR3 CD80 TNRC6C PDGFB PDGFRB PIK3R1 NRG2 FGF20 CHUK FGF22 FOXO1 PDPK1 MIR26A1 TNRC6A PPP2R5B FGF19 FGFR1 PRR5 EREG FGF7 PDGFA PIP4K2C PIK3CB FGF18 FGF4 PIK3R2 PPP2R5C ERBB3 HBEGF FGF3 VAV1 FOXO4 CDKN1B FGF9 BAD PPP2R5E PIK3AP1 KLB CREB1 FGF8 AKT2 PPP2CA PHLPP1 PPP2CB KITLG CDKN1A FGF17 ICOS BTC RPS6KB2 FGF2 AL358075.4 AKT1S1 AGO1 TSC2 MET NR4A1 MTOR ERBB4 FGF1 PIP5K1A MDM2 GSK3A TRIB3 FOXO3 AKT3 TNRC6B PIP4K2A -REAC:5654736 Signaling by FGFR1 FRS2 PIK3R3 PRKAR1A ADCY9 RASAL2 CALM1 MAP3K11 PPP2R5A DUSP1 ACTN2 RPS27A CSF2RB AL672043.1 DUSP9 PEA15 PSMD6 ADCY8 JAK3 SPTBN5 FLRT2 GFRA3 PSPN PSMD11 PSMD7 PSME3 INS HGF AGO2 RASGRP1 PIP5K1C NRG3 PTEN UBA52 CALM2 TP53 PSMD12 PSMB5 RASGRP4 PRKACB FGFRL1 MAP2K1 MOV10 WDR83 NRG4 FGFR2 DLG4 CNKSR2 NCAM1 PPP2R5D FRS3 INS-IGF2 RAF1 RANBP9 PIP4K2B SPTA1 ERBB2 ITPR1 LAT GRIN1 GRB2 MAPK3 PSMA1 VCL GFRA2 GSK3B CAMK2A PDGFRA MARK3 PPP2R1B ARRB2 RAP1A PSMC6 IRS1 AGO4 UBB FGF16 FYN GRIN2D IL5 YWHAB FGF5 IL2RG SHC3 BRAP INSR IER3 RASGRP3 PEBP1 CD28 PRKCG SPRY2 ARTN SHC1 ANGPT1 AKAP9 GRK2 FGF17 PSMA3 KITLG AKT1S1 PPP5C SEM1 RPS6KB2 PSMA7 PLCG1 SYNGAP1 ITPR2 FGF9 BAD PAQR3 APBB1IP CAMK4 PHLPP1 PPP2CA GDNF CREB1 AKT2 FGF8 KLB FLRT1 PSMA4 MDM2 DUSP5 PSMB4 SPTBN2 DAB2IP PIP4K2A PSMD4 AKT3 RASA3 TRIB3 AGO1 BRAF ANOS1 MTOR NR4A1 PSMC5 ITGB3 PDE1C GRIN2B AHCYL1 FOXO1 GFRA1 FGF20 JAK2 RASGEF1A PIK3R1 SPRED1 MIR26A1 SPTAN1 ADCY6 KBTBD7 FGG RET PSMD8 PSMB11 ITPR3 PDPK1 PTPN11 FGF23 PSMB10 AGO3 TRAT1 MIR26A2 PRKAR2A MAPK1 MKNK1 LCK GAB1 PDGFB ARAF PSMD2 PSMA8 FGFR3 NEFL PRKCA DUSP16 CSF2 ADCY7 RASA1 PRKACA DUSP4 PSMA5 EREG PRR5 DUSP8 PPP2R5B SOS1 FGF4 PIK3R2 RASAL1 PDGFA PIP4K2C FGF7 EGFR PRKAR2B MAP2K2 KL PRKCD PSMB2 PSMD9 FGFR4 AKT1 PSMB1 PRKAR1B PTPRA IQGAP1 PHB GRIN2A PDE1B PIK3CD VWF IRS2 ADCY4 CD19 DUSP2 LAMTOR3 PHLPP2 UBC CSK RASA4 SPTBN1 CAMK2B IL2 PIK3CA NRTN KIT CSF2RA SRC CAMK2D KRAS CNKSR1 PSMB7 CD86 RASGRF2 GRIN2C PPP2R1A PSMB6 FGF6 RASAL3 IL3 MAPKAP1 PSMD10 CAMK2G CASP9 GFRA4 RICTOR TEK PSMD1 PDE1A FGF10 SPRED2 EGF PSME4 KSR1 RAP1B PSMC2 JAK1 ADCY1 CBL THEM4 LAMTOR2 DUSP7 CALM3 RASGRF1 ADCY3 MLST8 TLN1 HRAS PSMC4 ADCY2 RAPGEF2 CDKN1A AL358075.4 FGF2 IL2RB BTC ICOS PIK3AP1 PPP2R5E PSMF1 CDKN1B RASA2 PSMA6 PSMC3 FOXO4 IL5RA FLRT3 PPP2CB PSMB9 GSK3A IL2RA IL3RA PIP5K1A FGF1 TNRC6B SPRED3 FOXO3 TSC2 NRAS SPTB ERBB4 DUSP6 FGA MET PTK2 PSME2 FGF22 ADCY5 CHUK PSMA2 PSMB3 PSMD13 NRG2 CUL3 PSMB8 TNRC6A SPTBN4 PIP5K1B DUSP10 NRG1 PDGFRB PSMC1 PSMD14 IL17RD TNRC6C CD80 KSR2 PPP2R5C VAV1 PSME1 FGB FGF3 PSMD3 ITGA2B HBEGF ERBB3 PSMD5 NF1 ARRB1 PRKACG FGFR1 FGF19 PRKCE FGF18 AC010132.3 PIK3CB SHC2 FN1 RBX1 -REAC:2172127 DAP12 interactions WDR83 NRG4 PRKACB MAP2K1 MOV10 PSMB5 PSMD12 RASGRP4 TP53 PPP2R5D CNKSR2 NCAM1 FGFR2 DLG4 INS HGF RASGRP1 AGO2 PSME3 PSMD7 RNASE1 PSPN GFRA3 PSMD11 CALM2 PTEN UBA52 CD300LB PIP5K1C NRG3 DUSP9 RPS27A CSF2RB AL672043.1 HLA-E ACTN2 MAP3K11 PPP2R5A DUSP1 PSMD6 JAK3 SPTBN5 ADCY8 PEA15 PRKAR1A ADCY9 PIK3R3 FRS2 CALM1 RASAL2 IL2RG FGF5 FYN GRIN2D YWHAB IL5 AGO4 FGF16 UBB PEBP1 CD28 RASGRP3 SHC3 BRAP INSR IER3 BTK RAP1A PLCG2 PPP2R1B ARRB2 MARK3 IRS1 PSMC6 GRIN1 GRB2 LAT ITPR1 KLRC2 LCP2 ERBB2 GSK3B CAMK2A PDGFRA VCL GFRA2 PSMA1 KLRK1 MAPK3 INS-IGF2 FRS3 SPTA1 CLEC5A RANBP9 PIP4K2B RAF1 BRAF AGO1 KLRD1 PDE1C GRIN2B NR4A1 ITGB3 PSMC5 MTOR SPTBN2 DAB2IP DUSP5 PSMB4 PSMA4 MDM2 TRIB3 RASA3 AKT3 PIP4K2A PSMD4 APBB1IP ITPR2 FGF9 BAD PAQR3 SYNGAP1 KLB CREB1 AKT2 PPP2CA FGF8 GDNF PHLPP1 CAMK4 PSMA3 KITLG GRK2 AKAP9 ANGPT1 FGF17 SHC1 ARTN PRKCG PLCG1 PSMA7 SEM1 RPS6KB2 PPP5C AKT1S1 PPP2R5B GRAP2 SOS1 DUSP8 PRR5 TYROBP EREG PDGFA PIP4K2C FGF7 SIGLEC14 PIK3R2 FGF4 RASAL1 CSF2 ADCY7 DUSP16 PRKCA PSMA5 DUSP4 PRKACA RASA1 GAB1 PRKAR2A TREM2 MAPK1 LCK TRAT1 MIR26A2 FGF23 PSMB10 PTPN11 AGO3 FGFR3 PSMA8 NEFL PSMD2 ARAF PDGFB PIK3R1 SIGLEC16 JAK2 FGF20 B2M RASGEF1A GFRA1 AHCYL1 FOXO1 PSMB11 ITPR3 PDPK1 KBTBD7 RET PSMD8 FGG ADCY6 MIR26A1 SPTAN1 SPRED1 CSF2RA KIT PIK3CA NRTN CAMK2B IL2 KRAS CAMK2D SRC KIR2DS4 NCR2 PHLPP2 DUSP2 CD19 LAMTOR3 ADCY4 RASA4 SPTBN1 CSK UBC PHB IQGAP1 PSMB1 PTPRA AKT1 PRKAR1B FGFR4 IRS2 VWF PIK3CD PDE1B GRIN2A MAP2K2 PRKAR2B EGFR PSMB2 PSMD9 KL PRKCD DUSP7 CALM3 RASGRF1 VAV2 THEM4 LAMTOR2 TLN1 PSMC4 HRAS MLST8 ADCY3 PSME4 EGF SPRED2 FGF10 PDE1A RAC1 ADCY1 JAK1 RAP1B PSMC2 KSR1 CASP9 CAMK2G PSMD10 PSMD1 TEK RICTOR GFRA4 RASGRF2 GRIN2C CD86 PSMB7 CNKSR1 IL3 MAPKAP1 SYK RASAL3 PPP2R1A PSMB6 FGF6 HLA-B SPTB NRAS TSC2 FGA MET PTK2 DUSP6 ERBB4 FGF1 IL2RA IL3RA PIP5K1A GSK3A FOXO3 CD300E SPRED3 TNRC6B FOXO4 PSMC3 PSMA6 CDKN1B RASA2 PPP2R5E PIK3AP1 PSMF1 PSMB9 PPP2CB IL5RA ADCY2 RAPGEF2 CDKN1A ICOS IL2RB BTC AL358075.4 FGF2 FGF19 NF1 FGFR1 PRKACG ARRB1 PSMD5 SHC2 FN1 RBX1 AC010132.3 PIK3CB FGF18 PRKCE KSR2 PPP2R5C HLA-C VAV3 TREM1 PSMD3 HBEGF ITGA2B ERBB3 FGF3 FGB PSME1 VAV1 NRG1 SIGLEC15 DUSP10 SPTBN4 PIP5K1B CD80 TNRC6C SIRPB1 IL17RD PSMC1 PDGFRB PSMD14 NRG2 CUL3 PSMB8 PSMA2 PSMB3 PSMD13 ADCY5 FGF22 CHUK PSME2 TNRC6A -REAC:5655253 Signaling by FGFR2 in disease NRAS FGF5 POLR2F GTF2F2 SOS1 FGF16 POLR2D PIK3CA FGF7 NCBP1 HRAS KRAS POLR2G FGF18 FGF4 FGFR2 FGF1 FGF10 POLR2K FGF3 POLR2J GRB2 GAB1 FGF23 POLR2C FGF9 POLR2H FGF8 POLR2A FGF17 FGF20 PIK3R1 GTF2F1 FRS2 POLR2I FGF22 POLR2L PLCG1 NCBP2 FGF2 FGF6 POLR2E POLR2B -REAC:5673000 RAF activation PPP2CB ARAF BRAP HRAS KRAS PPP2R5D PPP2CA SRC YWHAB PPP2R5A MAP3K11 PPP2R5E BRAF PPP2R5B PHB MAP2K1 NRAS KSR1 RAF1 PPP2R1A PPP2R1B MARK3 MAP2K2 PPP2R5C JAK2 -REAC:190236 Signaling by FGFR MAPKAP1 POLR2L IL3 RASAL3 FGF6 PSMB6 PPP2R1A GRIN2C RASGRF2 PSMB7 CD86 CNKSR1 POLR2A PSMD1 TEK HNRNPM RICTOR GFRA4 CASP9 CAMK2G PSMD10 CBL ADCY1 JAK1 RBFOX2 PSMC2 RAP1B KSR1 PSME4 EGF SPRED2 PDE1A FGF10 PSMC4 HRAS TLN1 NCBP1 MLST8 FGFBP1 ADCY3 HNRNPA1 CALM3 RASGRF1 DUSP7 THEM4 LAMTOR2 HNRNPF PSMB2 PSMD9 POLR2E PRKCD KL MAP2K2 PRKAR2B EGFR POLR2I IRS2 PIK3CD VWF PDE1B GRIN2A PHB PRKAR1B IQGAP1 AKT1 PTPRA PSMB1 FGFR4 RASA4 SPTBN1 CSK UBC PHLPP2 LAMTOR3 DUSP2 FGFBP2 CD19 ADCY4 KRAS SRC CAMK2D KIT CSF2RA NRTN PIK3CA CAMK2B IL2 TNRC6A PSMB8 NRG2 CUL3 ESRP1 PSMD13 PSMA2 PSMB3 CHUK ADCY5 FGF22 PSME2 TNRC6C CD80 IL17RD PSMD14 PDGFRB PSMC1 NRG1 DUSP10 TIA1 PIP5K1B SPTBN4 HBEGF ERBB3 ITGA2B PSMD3 FGF3 FGB POLR2J VAV1 PSME1 PPP2R5C KSR2 RBX1 SHC2 FN1 PIK3CB AC010132.3 PRKCE FGF18 FGF19 ARRB1 PRKACG FGFR1 NF1 PSMD5 ICOS BTC IL2RB POLR2B FGF2 AL358075.4 CDKN1A RAPGEF2 ADCY2 PSMB9 PPP2CB IL5RA FLRT3 ESRP2 FOXO4 PSMC3 PSMA6 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E FOXO3 HNRNPH1 SPRED3 TNRC6B FGF1 IL2RA PIP5K1A IL3RA GSK3A POLR2K MET FGA PTK2 DUSP6 ERBB4 NRAS SPTB POLR2D TSC2 SPTA1 PIP4K2B RANBP9 RAF1 FRS3 INS-IGF2 CAMK2A PDGFRA GSK3B GFRA2 POLR2H VCL PSMA1 MAPK3 GRB2 GRIN1 LAT ITPR1 ERBB2 TIAL1 IRS1 PSMC6 RAP1A ARRB2 PPP2R1B MARK3 CD28 PEBP1 RASGRP3 BRAP IER3 INSR SHC3 IL2RG FGF5 IL5 YWHAB GRIN2D FYN UBB FGF16 AGO4 CALM1 RASAL2 GTF2F1 ADCY9 PRKAR1A PIK3R3 FRS2 FLRT2 JAK3 ADCY8 SPTBN5 PSMD6 PEA15 DUSP9 AL672043.1 GALNT3 RPS27A CSF2RB ACTN2 DUSP1 MAP3K11 PPP2R5A CALM2 UBA52 PTEN NRG3 PIP5K1C RASGRP1 HGF AGO2 INS PSME3 PSMD7 PSMD11 PSPN GFRA3 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 NRG4 WDR83 POLR2F MAP2K1 MOV10 FGFRL1 PRKACB PSMB5 PSMD12 RASGRP4 TP53 PDPK1 ITPR3 NCBP2 PSMB11 PSMD8 RET FGG KBTBD7 ADCY6 MIR26A1 SPRED1 SPTAN1 PIK3R1 FGF20 JAK2 RASGEF1A GFRA1 FOXO1 AHCYL1 NEFL FGFR3 PSMA8 PSMD2 ARAF PDGFB GAB1 LCK MAPK1 MKNK1 PRKAR2A TRAT1 MIR26A2 PTBP1 PSMB10 FGF23 AGO3 POLR2C PTPN11 PSMA5 DUSP4 PRKACA RASA1 CSF2 ADCY7 DUSP16 FGFBP3 PRKCA PIP4K2C PDGFA FGF7 RASAL1 FGF4 PIK3R2 SOS1 PPP2R5B DUSP8 PRR5 EREG PLCG1 PSMA7 RPS6KB2 SEM1 PPP5C AKT1S1 KITLG PSMA3 FGF17 GRK2 ANGPT1 AKAP9 SHC1 PRKCG ARTN SPRY2 FLRT1 KLB CREB1 GDNF FGF8 AKT2 PPP2CA PHLPP1 CAMK4 APBB1IP PAQR3 ITPR2 FGF9 BAD SYNGAP1 TRIB3 RASA3 AKT3 PSMD4 PIP4K2A DAB2IP SPTBN2 PSMB4 DUSP5 MDM2 PSMA4 GRIN2B PDE1C PSMC5 ITGB3 NR4A1 ANOS1 MTOR POLR2G BRAF GTF2F2 AGO1 +REAC:2424491 DAP12 signaling IL17RD PSMC1 PDGFRB PSMD14 TNRC6C CD80 DUSP10 SPTBN4 PIP5K1B NRG1 TNRC6A FGF22 ADCY5 CHUK PSME2 CUL3 NRG2 PSMB8 PSMA2 PSMB3 PSMD13 AC010132.3 PIK3CB FGF18 PRKCE FN1 SHC2 RBX1 PSMD5 FGF19 NF1 ARRB1 FGFR1 PRKACG FGB PSME1 VAV1 PSMD3 ITGA2B HBEGF ERBB3 FGF3 KSR2 PPP2R5C VAV3 PPP2CB IL5RA PSMB9 CDKN1B RASA2 PPP2R5E PIK3AP1 PSMF1 FOXO4 PSMC3 PSMA6 AL358075.4 FGF2 ICOS IL2RB BTC ADCY2 RAPGEF2 CDKN1A DUSP6 ERBB4 PTK2 MET FGA TSC2 NRAS SPTB SPRED3 TNRC6B FOXO3 GSK3A FGF1 IL3RA PIP5K1A IL2RA GFRA4 PSMD1 TEK RICTOR PSMD10 CASP9 CAMK2G RASAL3 PPP2R1A PSMB6 FGF6 IL3 MAPKAP1 SYK CNKSR1 RASGRF2 GRIN2C PSMB7 CD86 ADCY3 TLN1 PSMC4 HRAS MLST8 VAV2 LAMTOR2 THEM4 DUSP7 RASGRF1 CALM3 RAP1B PSMC2 KSR1 RAC1 ADCY1 JAK1 SPRED2 PDE1A FGF10 PSME4 EGF PDE1B GRIN2A IRS2 VWF PIK3CD FGFR4 PHB AKT1 IQGAP1 PTPRA PSMB1 PRKAR1B KL PRKCD PSMD9 PSMB2 EGFR MAP2K2 PRKAR2B KRAS CAMK2D SRC PIK3CA NRTN IL2 CAMK2B KIT CSF2RA CSK UBC SPTBN1 RASA4 CD19 DUSP2 LAMTOR3 ADCY4 PHLPP2 ARAF PSMD2 PDGFB PSMA8 FGFR3 NEFL TRAT1 MIR26A2 FGF23 AGO3 PTPN11 PSMB10 GAB1 MAPK1 TREM2 PRKAR2A LCK ADCY6 SPRED1 MIR26A1 SPTAN1 PSMB11 PDPK1 ITPR3 KBTBD7 RET PSMD8 FGG GFRA1 AHCYL1 FOXO1 PIK3R1 RASGEF1A JAK2 B2M FGF20 PIK3R2 FGF4 RASAL1 FGF7 PIP4K2C PDGFA PRR5 TYROBP EREG PPP2R5B GRAP2 SOS1 DUSP8 PRKACA RASA1 PSMA5 DUSP4 PRKCA ADCY7 CSF2 DUSP16 PHLPP1 CAMK4 KLB GDNF AKT2 CREB1 PPP2CA FGF8 FGF9 ITPR2 BAD PAQR3 SYNGAP1 APBB1IP SEM1 RPS6KB2 AKT1S1 PPP5C PLCG1 PSMA7 SHC1 ARTN PRKCG PSMA3 KITLG GRK2 AKAP9 ANGPT1 FGF17 MTOR PDE1C GRIN2B NR4A1 ITGB3 PSMC5 AGO1 KLRD1 BRAF AKT3 PSMD4 PIP4K2A TRIB3 RASA3 MDM2 PSMA4 SPTBN2 DAB2IP DUSP5 PSMB4 PSMA1 MAPK3 KLRK1 GSK3B PDGFRA CAMK2A VCL GFRA2 ITPR1 KLRC2 LCP2 ERBB2 GRIN1 GRB2 LAT RAF1 SPTA1 RANBP9 PIP4K2B FRS3 INS-IGF2 RASGRP3 SHC3 IER3 INSR BRAP PEBP1 CD28 GRIN2D FYN YWHAB IL5 AGO4 UBB FGF16 IL2RG FGF5 PSMC6 IRS1 PPP2R1B ARRB2 MARK3 BTK PLCG2 RAP1A PEA15 PSMD6 ADCY8 JAK3 SPTBN5 ACTN2 PPP2R5A MAP3K11 DUSP1 DUSP9 RPS27A CSF2RB HLA-E AL672043.1 RASAL2 CALM1 PIK3R3 FRS2 PRKAR1A ADCY9 FGFR2 DLG4 PPP2R5D CNKSR2 NCAM1 RASGRP4 PSMD12 PSMB5 TP53 WDR83 NRG4 PRKACB MAP2K1 MOV10 PIP5K1C NRG3 CALM2 PTEN UBA52 PSMD7 RNASE1 PSPN GFRA3 PSMD11 INS RASGRP1 AGO2 HGF PSME3 +REAC:422475 Axon guidance SEMA3E PSME4 FGF10 TIAM1 RGMA JAK1 CD72 GRB7 COL6A5 PSMC2 SRGAP2 LAMTOR2 PAK4 VAV2 SEMA4A HRAS TLN1 PSMB7 KALRN RASGRF2 UNC5D DCC RAC2 CNKSR1 FES ARPC2 SRGAP3 EPHA4 LAMC1 PSMD10 CLASP2 MYL12A CDK5R1 GPC1 GFRA4 COL6A2 NEO1 LAMTOR3 EFNA1 UBC SCN9A CACNB3 IL2 WASL NRTN PIK3CA KRAS CHL1 CFL1 CRMP1 PRNP MAP2K2 EPHB4 EGFR PSMD9 PSMB2 EPHA1 KL PHB ABLIM1 PIK3CD TRPC7 ACTG1 CNTN6 RPS6KA5 PSENEN ACTB CD24 PPP2R5C ITGB1 ROCK2 ERBB3 ITGA2B NGEF HBEGF PSMD3 FGB ARRB1 DPYSL5 ABLIM2 PSMD5 RPS6KA1 PLXNA4 RBX1 FN1 SHC2 PIK3CB PAK6 PSMB3 CUL3 NRG2 SHANK3 ACTR3 CLTB CNTN1 ARHGEF12 SPTBN4 SCN3B ITGA10 PSMC1 CAP1 IL2RA RHOC EFNA5 COL6A6 NRAS NRP1 PLXNC1 SCN3A APH1A MET FGA PTK2 FARP2 ERBB4 DUSP6 RPS6KA2 ABL1 SCN2A RRAS EPHB2 SEMA3A BTC FGF2 AL358075.4 ARHGEF7 NCK1 NTN4 PPP2R5E CNTNAP1 RASA2 IL5RA SDCBP EFNB3 RAP1A MARK3 PPP2R1B IRS1 TRIO EPHA2 PSMC6 FGF5 EFNA4 IL2RG COL4A2 FGF16 IL5 YWHAB FYN GRIN2D RAP1GAP GAB2 BRAP RASGRP3 ROBO1 EPHA8 KIRREL RANBP9 LAT PLXNB3 COL6A3 GRB2 ERBB2 GFRA2 VCL CAMK2A GSK3B PSMA1 PSMD11 CLTC SCN7A APH1B EPHA6 MAP2K1 PRKACB PFN2 WDR83 PSMB5 NCAM1 ROBO3 PPP2R5D PAK2 TRPC3 FRS2 DOK6 RDX SCN10A ARPC1A EPHA3 CSF2RB MAP3K11 ACTN2 JAK3 SPTBN5 PSMD6 UNC5B ARHGEF28 PEA15 DUSP16 PRKCA SCN5A SHB PSMA5 RASA1 PRKACA AP2B1 SOS1 VASP TYROBP RND1 UNC5C MYL6 CACNA1D RASAL1 NCSTN JAK2 SDC2 FGF20 EFNB2 PSMD8 FGG RET SEMA4D SPRED1 DPYSL4 CDC42 MAPK1 GAB1 PSMB10 SLIT2 SLIT3 FGFR3 PSMA8 AP2A1 PDGFB PSMD2 LAMA1 DUSP5 COL9A3 DAB2IP SPTBN2 BUB1B-PAK6 BRAF ROCK1 PSEN2 TRPC5 L1CAM ITGB3 PLXND1 LAMB1 PAK1 AKAP9 KITLG ARTN NCK2 ITGA2 SEM1 AP2M1 APBB1IP ANK1 SYNGAP1 FGF9 RPS6KA6 FGF8 SH3KBP1 KLB DOK1 TRPC6 NFASC EGF COL4A3 SPRED2 DNM2 RAC1 SEMA7A SEMA6D KSR1 ALCAM COL4A1 RAP1B CLASP1 CALM3 RASGRF1 DUSP7 EFNA3 GIT1 DPYSL2 ARHGAP35 PSMC4 EPHA5 ENAH RPS6KA4 GRIN2C KIF4B IL3 PSMB6 FGF6 PPP2R1A RASAL3 CAMK2G ITGA5 ARHGEF11 ABL2 PSMD1 TEK ADAM10 DLG1 MYH10 RELN CACNA1S PLXNA3 DUSP2 RASA4 SPTBN1 ARPC1B CSK ITGA1 CSF2RA KIT HFE2 SEMA5A CAMK2B COL9A2 SRC CAMK2D UNC5A CACNA1C DCX LYPLA2 MMP9 VLDLR SCN8A IQGAP1 PTPRA PSMB1 AP2S1 FGFR4 VWF CLTCL1 SCN4A IRS2 GRIN2A HSP90AA1 VAV3 KSR2 FGF3 PSME1 RHOB PRKACG FGFR1 SCN11A NF1 FGF19 MYO10 CACNA1I FGF18 AC010132.3 PSMA2 PSMD13 SEMA6A PSMB8 PTPRC PSME2 FGF22 CSNK2A2 PAK3 AP2A2 PITPNA DOK5 NRG1 EPHB6 DUSP10 SLIT1 ABLIM3 SRGAP1 PSMD14 PDGFRB IL17RD IL3RA ARPC5 FGF1 PLXNB1 ITGAV CSNK2B SPRED3 SPTB MYL9 AGRN CLTA RPS6KA3 ITSN1 DOK2 YES1 RAPGEF2 ARPC4 ARPC3 SIAH2 GAP43 IL2RB LYN ACTR2 PSMC3 PSMA6 HSPA8 PSMF1 PRKCQ PSMB9 DOK4 SHTN1 PPP2CB DNM1 DPYSL3 ARRB2 GRB10 ANK2 CDK5 CACNB4 RHOG UBB KDR CSNK2A1 SCN2B PEBP1 MYH14 SHC3 RGMB NRCAM EPHB1 SCN4B EVL FRS3 VEGFA HSP90AB1 DAB1 SPTA1 RAF1 EFNA2 PAK5 GRIN1 SCN1A COL4A4 PDGFRA TRPC4 MAPK3 NCAN PSME3 KIF4A AGAP2 HGF RASGRP1 RNASE1 PSPN GFRA3 PSMD7 UBA52 CALM2 NRG3 PIP5K1C ITGA9 DOCK1 NRG4 ANK3 PSMD12 RASGRP4 CNKSR2 SH3GL2 DLG4 FGFR2 PFN1 PLXNA2 PIK3R3 CALM1 NUMB ROBO2 RASAL2 AL672043.1 RPS27A CACNB1 TRPC1 DUSP9 DUSP1 ST8SIA2 DLG3 PPP2R5A RHOA SCN1B KCNQ3 ARHGAP39 EPHA7 CAP2 CSF2 DUSP4 LIMK1 COL4A5 MYH11 SOS2 MYL12B DUSP8 PPP2R5B EREG FGF7 PDGFA SIAH1 MMP2 FGF4 PIK3R2 DNM3 RASGEF1A PIK3R1 CACNA1G GFRA1 CNTN2 KBTBD7 PSMB11 SPTAN1 CACNA1H TREM2 EFNB1 PTPN11 FGF23 NEFL ARAF PSMB4 ST8SIA4 PSMA4 RASA3 COL6A1 PSMD4 NRP2 EZR MYH9 MAPK7 NTN1 LIMK2 PSMC5 GRIN2B COL9A1 FGF17 ANGPT1 PDLIM7 PSMA3 EPHA10 EPHB3 SHC1 PSMA7 KCNQ2 PLCG1 PLXNA1 PPP5C PAQR3 GDNF PPP2CA CREB1 MSN CACNB2 +REAC:177929 Signaling by EGFR ADCY3 HRAS PSMC4 TLN1 MLST8 THEM4 LAMTOR2 CALM3 RASGRF1 DUSP7 PSMC2 RAP1B KSR1 ADCY1 CBL JAK1 SPRED2 PDE1A FGF10 PSME4 EGF ADAM10 GFRA4 PSMD1 TEK RICTOR PSMD10 CASP9 CAMK2G RASAL3 PSMB6 FGF6 PPP2R1A MAPKAP1 IL3 CNKSR1 LRIG1 RASGRF2 GRIN2C CD86 PSMB7 KRAS CAMK2D SRC NRTN PIK3CA IL2 CAMK2B CSF2RA KIT UBC CSK RASA4 SPTBN1 LAMTOR3 CD19 DUSP2 ADCY4 PHLPP2 PDE1B GRIN2A IRS2 PIK3CD VWF FGFR4 PHB PRKAR1B PSMB1 IQGAP1 PTPRA AKT1 PRKCD KL HGS SH3GL3 PSMB2 PSMD9 EGFR MAP2K2 PRKAR2B AC010132.3 PIK3CB FGF18 PRKCE RBX1 FN1 SHC2 PSMD5 FGF19 PRKACG ARRB1 FGFR1 NF1 FGB PSME1 VAV1 HBEGF ITGA2B ERBB3 PSMD3 FGF3 EPS15 KSR2 PPP2R5C ADAM12 IL17RD PSMD14 PSMC1 PDGFRB CD80 TNRC6C DUSP10 PIP5K1B SPTBN4 NRG1 TNRC6A CHUK ADCY5 FGF22 PSME2 PSMB8 NRG2 CUL3 PSMD13 PSMA2 PSMB3 DUSP6 ERBB4 MET FGA PTK2 TSC2 SPTB NRAS SPRED3 TNRC6B FOXO3 GSK3A FGF1 IL3RA IL2RA PIP5K1A PPP2CB IL5RA PSMB9 EPN1 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E PTPN3 FOXO4 PSMC3 PSMA6 ARHGEF7 FGF2 AL358075.4 ICOS BTC PXN IL2RB RAPGEF2 CDKN1A ADCY2 RASGRP3 INSR BRAP IER3 SPRY1 SHC3 CD28 PEBP1 IL5 YWHAB FYN GRIN2D UBB FGF16 AGO4 STAM IL2RG FGF5 PSMC6 IRS1 ARRB2 PPP2R1B MARK3 RAP1A PSMA1 MAPK3 PDGFRA CAMK2A GSK3B GFRA2 VCL ITPR1 ERBB2 GRB2 GRIN1 LAT RAF1 SPTA1 PIP4K2B RANBP9 INS-IGF2 FRS3 DLG4 SH3GL1 FGFR2 PPP2R5D NCAM1 SH3GL2 CNKSR2 PSMB5 RASGRP4 PSMD12 PTPN12 TP53 NRG4 WDR83 MAP2K1 MOV10 PRKACB NRG3 PIP5K1C CALM2 UBA52 PTEN PSMD7 PSMD11 GFRA3 PSPN AGO2 RASGRP1 HGF INS PSME3 PEA15 JAK3 SPTBN5 ADCY8 PSMD6 ACTN2 DUSP1 MAP3K11 PPP2R5A DUSP9 AL672043.1 RPS27A ADAM17 CSF2RB RASAL2 CALM1 PIK3R3 FRS2 ADCY9 PRKAR1A RASAL1 PIK3R2 FGF4 PIP4K2C PDGFA FGF7 PRR5 EREG SOS1 PPP2R5B DUSP8 PRKACA EPS15L1 RASA1 PSMA5 DUSP4 PRKCA CSF2 ADCY7 DUSP16 PSMD2 ARAF PAG1 PDGFB NEFL FGFR3 PSMA8 TRAT1 MIR26A2 PSMB10 PTPN11 AGO3 FGF23 GAB1 LCK MAPK1 PRKAR2A ADCY6 MIR26A1 SPTAN1 SPRED1 CDC42 ITPR3 PDPK1 PSMB11 RET FGG PSMD8 KBTBD7 GFRA1 FOXO1 AHCYL1 PIK3R1 JAK2 RASGEF1A FGF20 MTOR GRIN2B PDE1C ITGB3 PSMC5 NR4A1 AGO1 BRAF AKT3 PIP4K2A PSMD4 TRIB3 RASA3 MDM2 PSMA4 STAM2 DAB2IP SPTBN2 PSMB4 DUSP5 PHLPP1 CAMK4 KLB FGF8 AKT2 GDNF CREB1 PPP2CA SH3KBP1 PAQR3 FGF9 ITPR2 BAD SYNGAP1 APBB1IP RPS6KB2 SEM1 PPP5C AKT1S1 PLCG1 PSMA7 PTPRK SHC1 PRKCG SPRY2 ARTN KITLG PSMA3 FGF17 ANGPT1 GRK2 AKAP9 +REAC:2559583 Cellular Senescence E2F3 MDM4 MDM2 HIST3H3 CDC27 CBX2 ACD CDK2 CBX8 KDM6B TNRC6B RAD50 ANAPC2 MAPKAPK3 MAPK7 AGO1 MIR24-2 HIST1H4H CDC23 HIST2H4B RPS6KA3 TXN HIST3H2BB RNF2 MAP2K3 UBE2E1 CDKN1A HIST1H1C RPS6KA2 HIST1H2BA CCNE2 HIST1H2BC HIST1H2AB POT1 MAP2K4 H2AFB1 HIST1H2BE CDKN1B RB1 HIST2H3C HIST1H3E ANAPC7 HIRA ANAPC10 HIST1H4I HIST1H3A H2AFX PHC3 HIST1H4F H2AFZ UBE2D1 HIST1H1B TERF1 CEBPB HIST2H2AC HIST1H2AD MAP2K7 ANAPC15 HIST2H2AA4 FZR1 ATM HIST1H1E MRE11 RPS6KA1 TFDP2 HIST1H2BD HIST1H3J HIST1H1A HIST1H2BB HMGA2 CDK6 CDC16 HIST1H3F IFNB1 HIST1H2AC CDKN2B PHC1 ANAPC16 EHMT1 CABIN1 ETS1 TNRC6A BMI1 MAPK1 H2BFS CDKN2C HIST1H2BN HIST1H3C EHMT2 HIST1H2AE E2F1 AGO3 ANAPC5 TNRC6C H3F3B RELA H2AFV HIST2H3A HIST1H4K HMGA1 CDKN2A STAT3 CDC26 KAT5 EP400 HIST1H2BI UBA52 CDK4 MAPK14 HIST1H1D UBC LMNB1 HIST1H3H HIST1H2AJ MOV10 TP53 UBN1 HIST1H3B ANAPC1 TFDP1 HIST1H4D IL6 ASF1A FOS MAPK11 MAPKAPK5 NBN MIR24-1 ETS2 MAP4K4 MAPK10 TERF2 HIST1H2BO RPS27A CDKN2D CBX6 H2AFJ HIST2H4A HIST1H2BF CCNA2 HIST1H4A MAPK9 MAPK8 HIST2H2BE HIST1H2BG HIST4H4 HIST1H4B ID1 IGFBP7 EZH2 CCNE1 CCNA1 RBBP4 CBX4 MAP3K5 ERF UBE2C MINK1 H1F0 AGO4 HIST1H4L UBB EED TNIK TINF2 HIST1H2BJ HIST1H2BH H3F3A RING1 HIST1H3D E2F2 HIST2H3D HIST1H3I ANAPC11 ANAPC4 MAPKAPK2 JUN IL1A NFKB1 CXCL8 HIST1H2BK TERF2IP HIST1H3G PHC2 HIST1H4E RBBP7 HIST2H2AA3 HIST1H4C SP1 SCMH1 HIST1H2BL HIST1H2BM HIST1H4J MAP2K6 SUZ12 MAPK3 +REAC:5654699 SHC-mediated cascade:FGFR2 FGF9 FGF23 FGF16 GRB2 SOS1 FGF5 NRAS FGFR2 FGF4 FGF18 KRAS HRAS FGF8 FGF7 FGF22 SHC1 FGF10 FGF1 FGF20 FGF17 FGF6 FGF2 FGF3 +REAC:2428924 IGF1R signaling cascade RASGRF2 GRIN2C TLR9 PSMB7 CNKSR1 IL3 LAMTOR5 RASAL3 FGF6 PSMB6 PPP2R1A CAMK2G PSMD10 TEK PSMD1 STK11 GFRA4 PSME4 EGF PRKAG1 SPRED2 FGF10 JAK1 PSMC2 RAP1B EIF4E KSR1 CALM3 RASGRF1 DUSP7 PRKAG2 RRAGD LAMTOR2 THEM4 RPTOR PSMC4 HRAS TLN1 MLST8 MAP2K2 EGFR PSMB2 PSMD9 PDE3B KL PHB PSMB1 IQGAP1 PTPRA AKT1 FGFR4 IRS2 VWF GRIN2A LAMTOR3 DUSP2 RASA4 SPTBN1 CSK UBC CSF2RA KIT NRTN PIK3CA PIK3C3 IL2 CAMK2B KRAS CAMK2D SRC PRKAA2 PSMB8 CUL3 NRG2 PSMA2 PSMD13 PSMB3 STRADB FGF22 CAB39L PSME2 IGF2 EIF4EBP1 NRG1 DUSP10 TSC1 SPTBN4 IL17RD RPS6 PSMD14 PSMC1 PDGFRB PPP2R5C KSR2 HBEGF ERBB3 ITGA2B PSMD3 FGF3 FGB PSME1 FGF19 ARRB1 FGFR1 NF1 PSMD5 EEF2K RBX1 FN1 SHC2 IGF1 PIK3CB AC010132.3 FGF18 RAPGEF2 BTC IL2RB FGF2 PSMC3 RHEB PSMA6 RASA2 PSMF1 PPP2R5E PSMB9 PPP2CB IL5RA FGF1 IL2RA IL3RA PPM1A SPRED3 NRAS SPTB TSC2 FGA PTK2 MET DUSP6 ERBB4 FRS3 SPTA1 RANBP9 RAF1 RRAGA GRB2 GRIN1 RPS6KB1 LAT ERBB2 CAMK2A LAMTOR1 PDGFRA GFRA2 VCL PSMA1 PIK3R4 MAPK3 RAP1A ARRB2 PPP2R1B PRKAB1 MARK3 IRS1 SLC38A9 PSMC6 IL2RG FGF5 IL5 YWHAB GRIN2D FYN UBB FGF16 PEBP1 RASGRP3 BRAP SHC3 CAB39 RRAGB PRKAG3 FRS2 CALM1 RASAL2 DUSP9 RPS27A CSF2RB ACTN2 DUSP1 MAP3K11 PPP2R5A JAK3 SPTBN5 PSMD6 PEA15 RASGRP1 HGF PSME3 PRKAA1 PSMD7 PSMD11 PSPN GFRA3 CALM2 UBA52 NRG3 NRG4 WDR83 MAP2K1 RASGRP4 PSMD12 PSMB5 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 PIK3R1 FGF20 JAK2 RASGEF1A GFRA1 PDPK1 PSMB11 RET FGG PSMD8 KBTBD7 SPRED1 SPTAN1 EIF4B GAB1 MAPK1 FGF23 PSMB10 PTPN11 NEFL PSMA8 FGFR3 PSMD2 ARAF PDGFB CSF2 DUSP16 PSMA5 DUSP4 RASA1 SOS1 PPP2R5B DUSP8 IGF1R EREG PDGFA FGF7 RASAL1 FGF4 PIK3R2 KITLG PSMA3 FGF17 ANGPT1 AKAP9 EIF4G1 SHC1 ARTN PSMA7 IRS4 SEM1 AKT1S1 PPP5C APBB1IP LAMTOR4 PAQR3 PRKAB2 FGF9 SYNGAP1 KLB PPP2CA AKT2 GDNF FGF8 STRADA DAB2IP SPTBN2 PSMB4 DUSP5 PSMA4 TRIB3 RASA3 RRAGC PSMD4 BRAF GRIN2B ITGB3 PSMC5 MTOR +REAC:167044 Signalling to RAS NTRK1 CSF2 PPP2R5C KSR2 DUSP16 FGB PSME1 RASA1 PSMD3 PSMA5 ERBB3 ITGA2B HBEGF FGF3 DUSP4 PSMD5 EREG PPP2R5B FGF19 SOS1 NF1 MAPK12 FGFR1 DUSP8 ARRB1 AC010132.3 FGF4 FGF18 RASAL1 SHC2 FN1 RBX1 PDGFA FGF7 FGF22 GFRA1 PSME2 CUL3 NRG2 PSMB8 FGF20 RASGEF1A JAK2 PSMB3 PSMA2 PSMD13 SPRED1 SPTAN1 PSMB11 KBTBD7 FGG PSMD8 RET DUSP10 SPTBN4 PSMB10 FGF23 MAPK1 NRG1 PSMD2 ARAF IL17RD PDGFRB PSMC1 PSMD14 PDGFB FGFR3 PSMA8 NEFL PSMA4 SPTBN2 FGF1 DAB2IP DUSP5 IL3RA IL2RA PSMB4 PSMD4 SPRED3 RALA RASA3 MAPKAPK3 BRAF NRAS SPTB DUSP6 MAPK13 ERBB4 GRIN2B PSMC5 ITGB3 MET PTK2 FGA SHC1 ARTN PSMA3 KITLG RAPGEF2 AKAP9 ANGPT1 FGF17 SEM1 PPP5C FGF2 IL2RB PSMA7 BTC FGF9 PAQR3 RASA2 PPP2R5E PSMF1 SYNGAP1 APBB1IP PSMA6 PSMC3 PPP2CB IL5RA KLB PSMB9 FGF8 PPP2CA GDNF PPP2R1B ARRB2 SPRED2 MARK3 FGF10 PSME4 RAP1A EGF PSMC6 RAP1B PSMC2 KSR1 JAK1 IRS1 FYN GRIN2D YWHAB IL5 UBB LAMTOR2 FGF16 IL2RG DUSP7 CALM3 RASGRF1 FGF5 RASGRP3 SHC3 BRAP TLN1 PSMC4 HRAS PEBP1 CNKSR1 FRS3 MAPKAPK2 RASGRF2 GRIN2C PSMB7 RASAL3 PPP2R1A RAF1 FGF6 PSMB6 SPTA1 IL3 RANBP9 PSMD10 RALGDS ERBB2 GRIN1 GRB2 CAMK2G LAT RALB PSMA1 GFRA4 MAPK3 PSMD1 TEK PDGFRA CAMK2A VCL GFRA2 DUSP2 PSMD7 LAMTOR3 PSPN GFRA3 PSMD11 RASGRP1 HGF PSME3 MAPK14 NRG3 UBC CSK CALM2 UBA52 SPTBN1 RASA4 PSMB5 PSMD12 RASGRP4 NRTN CAMK2B IL2 WDR83 NRG4 CSF2RA KIT MAP2K1 FGFR2 DLG4 KRAS PPP2R5D CNKSR2 CAMK2D SRC NCAM1 EGFR FRS2 MAP2K2 MAPK11 RASAL2 KL CALM1 PSMD9 PSMB2 ACTN2 FGFR4 PPP2R5A MAP3K11 DUSP1 DUSP9 PHB PSMB1 RPS27A CSF2RB IQGAP1 PTPRA PEA15 GRIN2A NGF IRS2 PSMD6 JAK3 VWF SPTBN5 +REAC:5654700 FRS-mediated FGFR2 signaling GRIN2A PEA15 IRS2 JAK3 VWF SPTBN5 PSMD6 FGFR4 ACTN2 DUSP1 PPP2R5A MAP3K11 DUSP9 PHB RPS27A PTPRA CSF2RB PSMB1 IQGAP1 KL RASAL2 CALM1 PSMD9 PSMB2 EGFR FRS2 MAP2K2 DLG4 FGFR2 PPP2R5D KRAS NCAM1 CAMK2D CNKSR2 SRC NRTN RASGRP4 PSMB5 PSMD12 IL2 CAMK2B NRG4 WDR83 MAP2K1 CSF2RA KIT UBC CSK NRG3 CALM2 SPTBN1 UBA52 RASA4 LAMTOR3 PSMD7 DUSP2 PSMD11 PSPN GFRA3 HGF RASGRP1 PSME3 PSMA1 MAPK3 GFRA4 CAMK2A PDGFRA PSMD1 TEK GFRA2 VCL ERBB2 PSMD10 GRB2 GRIN1 LAT CAMK2G RASAL3 FGF6 PSMB6 RAF1 PPP2R1A IL3 SPTA1 RANBP9 CNKSR1 GRIN2C RASGRF2 FRS3 PSMB7 RASGRP3 BRAP SHC3 PSMC4 HRAS TLN1 PEBP1 IL5 YWHAB GRIN2D FYN FGF16 LAMTOR2 UBB RASGRF1 CALM3 IL2RG DUSP7 FGF5 PSMC2 PSMC6 RAP1B KSR1 IRS1 JAK1 ARRB2 SPRED2 PPP2R1B FGF10 MARK3 PSME4 RAP1A EGF PPP2CB IL5RA KLB PPP2CA FGF8 GDNF PSMB9 RASA2 PAQR3 FGF9 SYNGAP1 PSMF1 PPP2R5E APBB1IP PSMA6 PSMC3 SEM1 FGF2 PPP5C BTC PSMA7 IL2RB SHC1 ARTN KITLG RAPGEF2 PSMA3 FGF17 AKAP9 ANGPT1 DUSP6 ERBB4 GRIN2B MET PTK2 PSMC5 FGA ITGB3 BRAF SPTB NRAS PSMD4 SPRED3 RASA3 PSMA4 DAB2IP SPTBN2 FGF1 IL3RA IL2RA PSMB4 DUSP5 IL17RD PSMD2 ARAF PSMD14 PDGFB PSMC1 PDGFRB NEFL FGFR3 PSMA8 DUSP10 PSMB10 FGF23 PTPN11 SPTBN4 NRG1 MAPK1 SPTAN1 SPRED1 PSMB11 RET PSMD8 FGG KBTBD7 GFRA1 FGF22 PSME2 PSMB8 NRG2 CUL3 PSMD13 PSMB3 PSMA2 JAK2 RASGEF1A FGF20 AC010132.3 FGF18 RASAL1 FGF4 RBX1 FN1 SHC2 FGF7 PDGFA PSMD5 EREG SOS1 PPP2R5B FGF19 DUSP8 ARRB1 FGFR1 NF1 FGB PSME1 RASA1 ITGA2B HBEGF ERBB3 PSMD3 PSMA5 DUSP4 FGF3 PPP2R5C KSR2 CSF2 DUSP16 +REAC:187687 Signalling to ERKs LAMTOR3 DUSP2 CSK UBC MAPK14 SPTBN1 RASA4 NRTN IL2 CAMK2B CSF2RA KIT RAPGEF1 KRAS SRC CAMK2D EGFR MAP2K2 MAPK11 KL PSMB2 PSMD9 FGFR4 PHB PSMB1 IQGAP1 PTPRA GRIN2A IRS2 NGF KIDINS220 VWF SPRED2 FGF10 PSME4 EGF PSMC2 RAP1B KSR1 JAK1 LAMTOR2 CALM3 RASGRF1 DUSP7 HRAS PSMC4 TLN1 CNKSR1 RASGRF2 GRIN2C MAPKAPK2 PSMB7 RASAL3 PSMB6 FGF6 PPP2R1A IL3 PSMD10 CAMK2G GFRA4 TEK PSMD1 FGF1 IL3RA IL2RA SPRED3 RALA MAPKAPK3 NRAS SPTB DUSP6 MAPK13 ERBB4 MET PTK2 FGA RAPGEF2 FGF2 BTC IL2RB RASA2 PSMF1 PPP2R5E PSMC3 PSMA6 PPP2CB IL5RA PSMB9 NTRK1 KSR2 PPP2R5C FGB PSME1 HBEGF ITGA2B ERBB3 PSMD3 RIT2 FGF3 PSMD5 FGF19 ARRB1 FGFR1 NF1 MAPK12 AC010132.3 FGF18 RBX1 SHC2 FN1 FGF22 PSME2 PSMB8 NRG2 CUL3 PSMB3 PSMA2 PSMD13 DUSP10 SPTBN4 NRG1 IL17RD PSMD14 PSMC1 PDGFRB PSMD7 PSMD11 PSPN GFRA3 HGF RASGRP1 PSME3 NRG3 CALM2 UBA52 PSMB5 PSMD12 RASGRP4 NRG4 WDR83 MAP2K1 DLG4 FGFR2 PPP2R5D NCAM1 CNKSR2 FRS2 RASAL2 CALM1 ACTN2 DUSP1 MAP3K11 PPP2R5A DUSP9 CSF2RB RPS27A PEA15 JAK3 SPTBN5 PSMD6 ARRB2 PPP2R1B MARK3 RAP1A PSMC6 IRS1 IL5 YWHAB GRIN2D FYN UBB FGF16 IL2RG FGF5 RASGRP3 BRAP SHC3 PEBP1 FRS3 RAF1 SPTA1 RANBP9 RALGDS ERBB2 GRB2 GRIN1 LAT PSMA1 RALB MAPK3 CAMK2A PDGFRA GFRA2 VCL PSMA4 DAB2IP SPTBN2 PSMB4 DUSP5 PSMD4 RASA3 RIT1 BRAF GRIN2B ITGB3 PSMC5 SHC1 ARTN KITLG PSMA3 FGF17 ANGPT1 AKAP9 SEM1 PPP5C PLCG1 PSMA7 PAQR3 FGF9 SYNGAP1 APBB1IP CRK KLB GDNF PPP2CA FGF8 CSF2 DUSP16 RASA1 PSMA5 DUSP4 EREG SOS1 PPP2R5B DUSP8 RASAL1 FGF4 PDGFA FGF7 GFRA1 RASGEF1A FGF20 JAK2 SPTAN1 SPRED1 PSMB11 PSMD8 RET FGG KBTBD7 FGF23 PSMB10 MAPK1 ARAF PSMD2 CRKL PDGFB NEFL FGFR3 PSMA8 +REAC:180336 SHC1 events in EGFR signaling IL3 SPTA1 RANBP9 RASAL3 PSMB6 FGF6 PPP2R1A RAF1 GRIN2C RASGRF2 FRS3 PSMB7 CNKSR1 CAMK2A PDGFRA PSMD1 TEK GFRA2 VCL PSMA1 MAPK3 GFRA4 GRB2 GRIN1 CAMK2G LAT ERBB2 PSMD10 IRS1 JAK1 PSMC2 RAP1B PSMC6 KSR1 PSME4 EGF RAP1A SPRED2 ARRB2 PPP2R1B FGF10 MARK3 PSMC4 HRAS TLN1 PEBP1 RASGRP3 BRAP SHC3 RASGRF1 CALM3 DUSP7 IL2RG FGF5 IL5 YWHAB GRIN2D FYN FGF16 UBB LAMTOR2 CALM1 PSMB2 PSMD9 RASAL2 KL MAP2K2 EGFR FRS2 IRS2 VWF JAK3 SPTBN5 PSMD6 PEA15 GRIN2A PHB DUSP9 PSMB1 CSF2RB PTPRA RPS27A IQGAP1 FGFR4 ACTN2 DUSP1 PPP2R5A MAP3K11 CALM2 UBA52 SPTBN1 RASA4 CSK UBC NRG3 HGF RASGRP1 PSME3 LAMTOR3 DUSP2 PSMD7 PSMD11 GFRA3 PSPN PPP2R5D KRAS NCAM1 CAMK2D CNKSR2 SRC DLG4 FGFR2 NRG4 WDR83 KIT MAP2K1 CSF2RA NRTN PSMD12 PSMB5 RASGRP4 CAMK2B IL2 PSMB11 FGG PSMD8 RET KBTBD7 SPTAN1 SPRED1 PSMB8 NRG2 CUL3 PSMA2 PSMB3 PSMD13 JAK2 RASGEF1A FGF20 GFRA1 FGF22 PSME2 NEFL FGFR3 PSMA8 IL17RD ARAF PSMD2 PSMD14 PDGFB PSMC1 PDGFRB NRG1 MAPK1 DUSP10 PSMB10 FGF23 SPTBN4 HBEGF ERBB3 ITGA2B PSMD3 PSMA5 DUSP4 FGF3 FGB RASA1 PSME1 CSF2 PPP2R5C KSR2 DUSP16 RBX1 FN1 SHC2 FGF7 PDGFA AC010132.3 RASAL1 FGF18 FGF4 SOS1 FGF19 PPP2R5B FGFR1 ARRB1 DUSP8 NF1 PSMD5 EREG PSMA7 BTC IL2RB SEM1 FGF2 PPP5C RAPGEF2 KITLG PSMA3 FGF17 ANGPT1 AKAP9 SHC1 ARTN KLB FGF8 GDNF PPP2CA PSMB9 PPP2CB IL5RA APBB1IP PSMC3 PSMA6 RASA2 PAQR3 FGF9 SYNGAP1 PSMF1 PPP2R5E RASA3 SPRED3 PSMD4 DAB2IP SPTBN2 FGF1 IL3RA IL2RA PSMB4 DUSP5 PSMA4 GRIN2B PSMC5 ITGB3 FGA MET PTK2 DUSP6 ERBB4 BRAF NRAS SPTB +REAC:4420097 VEGFA-VEGFR2 Pathway DUSP9 CSF2RB RPS27A RHOA ACTN2 PTK2B MAP3K11 PPP2R5A DUSP1 PSMD6 SPTBN5 JAK3 PEA15 BRK1 FRS2 CALM1 RASAL2 WDR83 NRG4 PRKACB DOCK1 MAP2K1 PSMD12 PSMB5 RASGRP4 PPP2R5D CNKSR2 NCAM1 FGFR2 PAK2 DLG4 HGF RASGRP1 PSME3 PSMD7 GFRA3 PSPN RNASE1 PSMD11 CALM2 UBA52 NRG3 GRIN1 GRB2 LAT ITPR1 NOS3 ERBB2 CAMK2A PDGFRA VCL GFRA2 PSMA1 MAPK3 FRS3 VEGFA SPTA1 RANBP9 RAF1 IL2RG CYBB FGF5 GRIN2D FYN IL5 YWHAB KDR UBB FGF16 PEBP1 PRKCB RASGRP3 SHC3 NCKAP1L BRAP RAP1A PPP2R1B ARRB2 MARK3 IRS1 PSMC6 APBB1IP CRK CYFIP2 ITPR2 FGF9 ELMO1 PAQR3 SYNGAP1 KLB FGF8 PPP2CA AKT2 GDNF PSMA3 KITLG ANGPT1 AKAP9 PAK1 FGF17 NCK2 SHC1 ARTN PLCG1 PSMA7 SEM1 PPP5C BRAF ROCK1 GRIN2B ITGB3 PSMC5 CTNNA1 MTOR SPTBN2 DAB2IP DUSP5 PSMB4 PSMA4 TRIB3 RASA3 AKT3 PSMD4 MAPK1 FGF23 PSMB10 FGFR3 PSMA8 AXL NEFL ARAF PSMD2 PDGFB PIK3R1 RASGEF1A FGF20 JAK2 GFRA1 AHCYL1 WASF1 PSMB11 PDPK1 ITPR3 KBTBD7 RET PSMD8 FGG CAV1 CDC42 SPRED1 SPTAN1 PPP2R5B SOS1 DUSP8 PRR5 EREG FGF7 PDGFA PIK3R2 FGF4 RASAL1 CSF2 DUSP16 PRKCA BCAR1 PSMA5 SHB DUSP4 PRKACA RASA1 PHB PSMB1 AKT1 PTPRA IQGAP1 FGFR4 IRS2 VWF BAIAP2 HSP90AA1 GRIN2A WASF2 CDH5 MAP2K2 MAPK11 EGFR PSMD9 PSMB2 KL PRKCD CSF2RA KIT PIK3CA NRTN CAMK2B IL2 KRAS CAMK2D SRC DUSP2 LAMTOR3 ABI1 RASA4 SPTBN1 MAPK14 UBC CSK CAMK2G PSMD10 TEK PSMD1 RICTOR GFRA4 MAPKAPK2 GRIN2C RASGRF2 PSMB7 ELMO2 CNKSR1 IL3 MAPKAP1 RASAL3 PRKCZ PPP2R1A FGF6 PSMB6 DUSP7 CALM3 RASGRF1 ABI2 NCF1 VAV2 THEM4 LAMTOR2 TLN1 PSMC4 HRAS MLST8 CTNNB1 PSME4 EGF SPRED2 FGF10 RAC1 JAK1 RAP1B PSMC2 KSR1 NCK1 PSMC3 PSMA6 RASA2 PPP2R5E NCF2 PSMF1 PSMB9 PPP2CB IL5RA RAPGEF2 WASF3 NCF4 PXN IL2RB BTC FGF2 MAPKAPK3 JUP SPTB NRAS CTNND1 MET FGA PTK2 DUSP6 MAPK13 CYBA ERBB4 FGF1 IL2RA IL3RA HSPB1 ITGAV SPRED3 NRG1 SH2D2A DUSP10 SPTBN4 IL17RD PSMC1 PDGFRB PSMD14 NRG2 CUL3 PSMB8 PSMD13 PSMA2 PSMB3 FGF22 PSME2 PAK3 CYFIP1 FGF19 NF1 MAPK12 FGFR1 ARRB1 PRKACG PSMD5 SHC2 FN1 RBX1 SPHK1 AC010132.3 PIK3CB FGF18 KSR2 PPP2R5C VAV3 NCKAP1 ROCK2 PSMD3 HBEGF ITGA2B ERBB3 FGF3 FGB VAV1 PSME1 +REAC:112399 IRS-mediated signalling CSF2 DUSP16 RASA1 PSMA5 DUSP4 EREG SOS1 PPP2R5B DUSP8 RASAL1 FGF4 PIK3R2 FGF7 PDGFA GFRA1 PIK3R1 RASGEF1A JAK2 FGF20 SPTAN1 SPRED1 PDPK1 PSMB11 FGG RET PSMD8 KBTBD7 PSMB10 FGF23 PTPN11 GAB1 EIF4B MAPK1 ARAF PSMD2 PDGFB NEFL PSMA8 FGFR3 PSMA4 DAB2IP SPTBN2 PSMB4 DUSP5 RRAGC PSMD4 TRIB3 RASA3 BRAF MTOR GRIN2B PSMC5 ITGB3 SHC1 ARTN KITLG PSMA3 FGF17 EIF4G1 ANGPT1 AKAP9 SEM1 AKT1S1 PPP5C PSMA7 PAQR3 PRKAB2 FGF9 SYNGAP1 APBB1IP LAMTOR4 STRADA KLB FGF8 PPP2CA GDNF AKT2 ARRB2 PPP2R1B PRKAB1 MARK3 RAP1A SLC38A9 PSMC6 IRS1 IL5 YWHAB FYN GRIN2D FGF16 UBB IL2RG FGF5 RASGRP3 BRAP SHC3 PEBP1 FRS3 RAF1 RRAGA SPTA1 RANBP9 ERBB2 GRB2 GRIN1 RPS6KB1 LAT PSMA1 PIK3R4 MAPK3 PDGFRA LAMTOR1 CAMK2A GFRA2 VCL PSMD7 PSMD11 GFRA3 PSPN RASGRP1 HGF PRKAA1 PSME3 NRG3 CALM2 UBA52 PSMB5 RASGRP4 PSMD12 NRG4 WDR83 MAP2K1 DLG4 FGFR2 PPP2R5D NCAM1 CNKSR2 PRKAG3 FRS2 CAB39 RRAGB RASAL2 CALM1 ACTN2 DUSP1 MAP3K11 PPP2R5A DUSP9 CSF2RB RPS27A PEA15 SPTBN5 JAK3 PSMD6 KSR2 PPP2R5C FGB PSME1 HBEGF ERBB3 ITGA2B PSMD3 FGF3 PSMD5 EEF2K FGF19 FGFR1 ARRB1 NF1 AC010132.3 PIK3CB FGF18 RBX1 SHC2 FN1 FGF22 CAB39L PSME2 PSMB8 NRG2 CUL3 PSMD13 PSMB3 PSMA2 STRADB DUSP10 TSC1 SPTBN4 NRG1 EIF4EBP1 IL17RD RPS6 PSMD14 PDGFRB PSMC1 FGF1 IL3RA IL2RA SPRED3 PPM1A TSC2 NRAS SPTB DUSP6 ERBB4 MET FGA PTK2 RAPGEF2 FGF2 BTC IL2RB RASA2 PSMF1 PPP2R5E PSMA6 PSMC3 RHEB PPP2CB IL5RA PSMB9 SPRED2 FGF10 PSME4 PRKAG1 EGF PSMC2 RAP1B EIF4E KSR1 JAK1 RRAGD PRKAG2 LAMTOR2 THEM4 CALM3 RASGRF1 DUSP7 PSMC4 HRAS RPTOR TLN1 MLST8 CNKSR1 GRIN2C RASGRF2 TLR9 PSMB7 LAMTOR5 RASAL3 PSMB6 FGF6 PPP2R1A IL3 PSMD10 CAMK2G GFRA4 PSMD1 STK11 TEK LAMTOR3 DUSP2 UBC CSK RASA4 SPTBN1 NRTN PIK3CA PIK3C3 IL2 CAMK2B KIT CSF2RA PRKAA2 KRAS SRC CAMK2D EGFR MAP2K2 KL PDE3B PSMB2 PSMD9 FGFR4 PHB AKT1 IQGAP1 PSMB1 PTPRA GRIN2A IRS2 VWF +REAC:5654712 FRS-mediated FGFR4 signaling PSMD5 EREG PPP2R5B FGF19 SOS1 NF1 DUSP8 FGFR1 ARRB1 AC010132.3 FGF4 FGF18 RASAL1 SHC2 FN1 RBX1 FGF7 PDGFA PPP2R5C KSR2 CSF2 DUSP16 FGB RASA1 PSME1 PSMD3 PSMA5 ITGA2B ERBB3 HBEGF FGF3 DUSP4 DUSP10 SPTBN4 PTPN11 FGF23 PSMB10 MAPK1 NRG1 PSMD2 ARAF IL17RD PDGFRB PSMC1 PDGFB PSMD14 FGFR3 PSMA8 NEFL FGF22 GFRA1 PSME2 CUL3 NRG2 PSMB8 JAK2 FGF20 RASGEF1A PSMA2 PSMB3 PSMD13 SPTAN1 SPRED1 PSMB11 KBTBD7 PSMD8 RET FGG BRAF NRAS SPTB DUSP6 ERBB4 GRIN2B PSMC5 FGA MET PTK2 ITGB3 PSMA4 SPTBN2 FGF1 DAB2IP DUSP5 IL3RA PSMB4 IL2RA PSMD4 SPRED3 RASA3 FGF9 RASA2 PAQR3 PPP2R5E SYNGAP1 PSMF1 APBB1IP PSMA6 PSMC3 PPP2CB IL5RA KLB PSMB9 GDNF FGF8 PPP2CA SHC1 ARTN PSMA3 KITLG RAPGEF2 ANGPT1 AKAP9 FGF17 SEM1 PPP5C FGF2 IL2RB PSMA7 BTC GRIN2D FYN IL5 YWHAB FGF16 UBB LAMTOR2 DUSP7 IL2RG RASGRF1 CALM3 FGF5 RASGRP3 SHC3 BRAP TLN1 HRAS PSMC4 PEBP1 PPP2R1B SPRED2 ARRB2 MARK3 FGF10 PSME4 EGF RAP1A PSMC6 RAP1B PSMC2 KSR1 IRS1 JAK1 PSMD10 ERBB2 GRIN1 GRB2 CAMK2G LAT PSMA1 GFRA4 MAPK3 PSMD1 TEK CAMK2A PDGFRA VCL GFRA2 CNKSR1 FRS3 GRIN2C RASGRF2 PSMB7 RASAL3 RAF1 PPP2R1A FGF6 PSMB6 SPTA1 IL3 RANBP9 PSMD12 RASGRP4 PSMB5 NRTN CAMK2B IL2 WDR83 NRG4 MAP2K1 KIT CSF2RA FGFR2 DLG4 PPP2R5D KRAS CNKSR2 CAMK2D SRC NCAM1 PSMD7 DUSP2 LAMTOR3 PSPN GFRA3 PSMD11 RASGRP1 HGF PSME3 NRG3 CSK UBC CALM2 RASA4 SPTBN1 UBA52 ACTN2 FGFR4 PPP2R5A MAP3K11 DUSP1 PHB DUSP9 IQGAP1 PTPRA RPS27A CSF2RB PSMB1 GRIN2A PEA15 IRS2 PSMD6 SPTBN5 VWF JAK3 EGFR FRS2 MAP2K2 KL RASAL2 CALM1 PSMB2 PSMD9 +REAC:180292 GAB1 signalosome SRC PPP2R5D FGFR2 MOV10 KIT NRG4 TP53 PIK3CA PTEN PIP5K1C NRG3 CSK PHLPP2 INS AGO2 HGF CD19 PIK3CD IRS2 AKT1 AL672043.1 PPP2R5A FGFR4 KL FRS2 PIK3R3 EGFR MLST8 CD28 INSR IER3 FGF5 AGO4 FGF16 THEM4 FYN IRS1 EGF FGF10 PPP2R1B RICTOR GSK3B PDGFRA MAPK3 CASP9 GRB2 ERBB2 PIP4K2B MAPKAP1 PPP2R1A FGF6 CD86 INS-IGF2 NR4A1 MET ERBB4 MTOR TSC2 AGO1 FOXO3 TRIB3 PIP4K2A TNRC6B AKT3 PIP5K1A FGF1 GSK3A MDM2 FGF8 AKT2 CREB1 PPP2CA KLB PPP2CB PHLPP1 FOXO4 PIK3AP1 PPP2R5E BAD FGF9 CDKN1B PXN BTC ICOS AL358075.4 AKT1S1 FGF2 RPS6KB2 FGF17 CDKN1A KITLG PIP4K2C FGF7 PDGFA PIK3R2 FGF4 FGF18 PIK3CB FGFR1 PPP2R5B FGF19 EREG PRR5 FGF3 HBEGF ERBB3 VAV1 PPP2R5C FGFR3 CD80 TNRC6C PDGFRB PAG1 PDGFB MAPK1 NRG1 LCK GAB1 FGF23 PIP5K1B AGO3 PTPN11 TRAT1 MIR26A2 PDPK1 TNRC6A MIR26A1 FGF20 NRG2 PIK3R1 FOXO1 FGF22 CHUK +REAC:2262752 Cellular responses to stress HIST1H4E WIPI2 ATG4B MRPL18 DCTN2 PRDX5 RBBP7 RRAGA VEGFA HSP90AB1 ANAPC11 NFKB1 ATG14 WTIP LAMTOR1 CAMK2A NUDT2 GSK3B HIST1H2BM PSMA1 MAP2K6 HSPA4 PIK3R4 CHMP4A MAPK3 RPS19BP1 TXNRD1 ATG9A SLC38A9 PSMC6 RPA2 HIST1H4B EZH2 PRKAB1 HIST1H2BJ HSPA1B TINF2 HSF1 RING1 HIST1H3I EGLN1 HIST1H3D CYBB EED UBB AGO4 MAPKAPK5 ETS2 TERF2 MAPK10 MAP4K4 HIF1A CHMP4C RRAGB PRKAG3 NUP88 FKBP4 GSTP1 MAPK9 ERO1A PSMD6 MAPK8 HIGD1A HIST1H2BO ATOX1 RPS27A CDKN2D SOD2 SOD1 HIST1H2BI DCTN4 DYNC1H1 EP400 UBA52 STIP1 CDK4 HSPA5 BAG5 HIST1H1D VCP PRDX2 PSME3 CDKN2A PRKAA1 ATG4D HSPA14 NOX5 STAT3 PSMD7 PSMD11 ANAPC1 TFDP1 HIST1H3B IL6 ASF1A NUP153 LMNB1 MOV10 CCAR2 AMBRA1 HIST1H2AJ ATG101 PSMD12 PSMB5 TP53 GML EHMT1 NUP62 PSMB11 ANAPC16 PSMD8 CABIN1 HIF3A CDK6 LIMD1 HMGA2 FKBPL EGLN3 NUP133 RPA3 HIST1H2AC UVRAG GPX3 PGR ATG4C PHC1 PSMA8 ANAPC5 H2AFV HIST2H3A RELA NUP37 PSMD2 CHMP7 NUP35 BMI1 BAG4 ATG9B MAPK1 HIST1H2BN E2F1 PSMB10 AGO3 HIST1H2AE HIST1H3C HIST1H4F PHC3 PSMA5 CHMP4B HIST1H1B UBE2D1 UBE2D2 TERF1 VHL HIRA POM121C HIST1H4I AAAS NDC1 CAT HIST1H1E TFDP2 HIST1H3J HIST1H1A EGLN2 DNAJC2 CEBPB MAP2K7 EPAS1 ELOB CCNE2 DNAJB1 PSMA7 SEM1 HSPA4L DNAJA2 AKT1S1 NR3C1 RAE1 PSMA3 HIST1H1C RPA1 NUP107 HIST2H3C HIST1H3E NUP43 HSPA12B LAMTOR4 MAP2K4 DCTN1 PRKAB2 HSPA2 NUP58 GPX1 HSPB2 BAG1 AR RRAGC ULK1 RAD50 PSMD4 E2F3 HIKESHI PSMB4 MDM4 NUP50 HSBP1 NUP214 P4HB MDM2 PSMA4 DEDD2 BECN1 HSPA7 CDC27 ATG10 PSMC5 HIST2H4B CHMP6 NUP210 MTOR HIST3H2BB GPX2 CHMP3 MAPK7 AGO1 MIR24-2 PHC2 HIST1H3G ATG5 ARNT LAMTOR5 PSMB6 GABARAPL2 WIPI1 ANAPC4 MAPKAPK2 IL1A PSMB7 JUN CXCL8 EEF1A1 MAP1LC3A TERF2IP HIST1H2BK PSMD1 SOD3 SCMH1 HIST1H2BL SUZ12 CYCS HIST1H4J HIST2H2AA3 CAMK2G HIST1H4C CHMP2A BAG3 DYNC1LI2 SP1 PSMD10 MAP3K5 CBX4 ERF CA9 PSMC2 UBE2C HDAC6 PSME4 DYNLL2 PRKAG1 HIST4H4 ATG12 DCTN5 ID1 CCNA1 CCNE1 RBBP4 IGFBP7 PSMC4 RPTOR TNIK PRDX3 MLST8 CREBBP H3F3A HIST1H2BH CUL2 HIST2H3D EPO EP300 E2F2 MINK1 H1F0 MAP1LC3C BAG2 NCF1 MAP1LC3B PRKAG2 SIRT1 HSPA1A RRAGD LAMTOR2 NUP54 HIST1H4L DYNC1I2 MIR24-1 NBN PSMD9 PSMB2 FOS MAPK11 NOX4 AQP8 WDR45 CRYBA4 GPX5 HIST2H2BE HSP90AA1 COL4A6 HIST1H2BG ATP7A PSMB1 CBX6 HIST1H2BF CCNA2 HIST1H4A H2AFJ HIST2H4A DCTN3 RB1CC1 NUP160 TPR UBC MAPK14 HMGA1 DYNC1LI1 GABARAPL3 LAMTOR3 MTMR3 KAT5 CDC26 PRDX6 HIST1H4D CAMK2D PRKAA2 ATG7 GPX7 HIST1H3H HSPA6 DNAJA4 PIK3C3 TNFRSF21 CAMK2B UBN1 GSR ETS1 ST13 TNRC6A DYNC1I1 HIST1H3F PSMB8 CDC16 HIST1H2BB POM121 HSPA1L IFNB1 UBE2D3 PSMA2 PSMD13 PSMB3 HSPA13 RANBP2 PSME2 CDKN2B H3F3B TNRC6C YWHAE CITED2 GABARAPL1 PSMD14 PSMC1 HIST1H4K NR3C2 CDKN2C H2BFS HSPA12A TSC1 EHMT2 ATG4A H2AFZ MTMR14 H2AFX PSMD3 GPX6 PSME1 NUPL2 ANAPC10 DNAJC7 GPX8 HIST1H3A FZR1 RBX1 HIST1H2BD DCTN6 RPS6KA1 NUP85 MRE11 ATM NUP205 AC010132.3 HSPA9 HIST2H2AC FKBP5 NUP155 HIST1H2AD ANAPC15 PSMD5 HIST2H2AA4 SEH1L HIST1H2AB HIST1H2BC HIST1H2BA NCF4 POT1 ATR PTGES3 SERPINH1 ATG3 DNAJA1 CHMP2B AJUBA CDKN1A UBE2E1 MAP2K3 RPS6KA2 HIF1AN TXN2 NUP98 ANAPC7 PSMB9 ATG13 DYNLL1 HSPA8 H2AFB1 RHEB PSMC3 PSMA6 HSPH1 RLN1 CDKN1B HIST1H2BE PSMF1 ELOC RB1 NCF2 ATG16L1 CDK2 CCS CBX8 KDM6B TNRC6B TXNRD2 NUP188 HIST3H3 HSPB1 CBX2 ACD CDC23 RPS6KA3 TXN PRDX1 RNF2 NUP93 CYBA MAPKAPK3 ANAPC2 GABARAP DNAJB6 WDR45B TSC2 HIST1H4H +REAC:198203 PI3K/AKT activation MTOR ERBB4 MET NR4A1 TSC2 AGO1 AKT3 PIP4K2A TNRC6B TRIB3 FOXO3 MDM2 GSK3A FGF1 PIP5K1A PPP2CB PHLPP1 KLB FGF8 PPP2CA CREB1 AKT2 CDKN1B BAD FGF9 PPP2R5E PIK3AP1 FOXO4 RPS6KB2 FGF2 AL358075.4 AKT1S1 ICOS BTC KITLG CDKN1A FGF17 PIK3CB FGF18 PIK3R2 FGF4 FGF7 PDGFA PIP4K2C PRR5 EREG FGF19 PPP2R5B FGFR1 VAV1 ERBB3 HBEGF FGF3 NTRK1 PPP2R5C PDGFB PDGFRB CD80 TNRC6C FGFR3 TRAT1 MIR26A2 PIP5K1B PTPN11 AGO3 FGF23 GAB1 LCK NRG1 MAPK1 MIR26A1 TNRC6A PDPK1 CHUK FGF22 FOXO1 PIK3R1 NRG2 FGF20 FGFR2 PPP2R5D SRC PIK3CA TP53 NRG4 MOV10 KIT NRG3 PIP5K1C PTEN CD19 HGF AGO2 INS PHLPP2 IRS2 NGF PIK3CD FGFR4 RHOA PPP2R5A AL672043.1 AKT1 KL EGFR PIK3R3 FRS2 IER3 INSR CD28 MLST8 FYN FGF16 THEM4 AGO4 FGF5 IRS1 PPP2R1B FGF10 EGF MAPK3 PDGFRA GSK3B RICTOR ERBB2 CASP9 GRB2 FGF6 PPP2R1A MAPKAP1 PIP4K2B INS-IGF2 CD86 +REAC:194138 Signaling by VEGF KSR1 RAP1B PSMC2 JAK1 RAC1 FGF10 SPRED2 EGF PSME4 CTNNB1 MLST8 TLN1 HRAS PSMC4 LAMTOR2 THEM4 VAV2 NCF1 DUSP7 RASGRF1 CALM3 ABI2 PPP2R1A PSMB6 FGF6 RASAL3 PRKCZ IL3 MAPKAP1 CNKSR1 ELMO2 PSMB7 MAPKAPK2 GRIN2C RASGRF2 GFRA4 RICTOR TEK PSMD1 PSMD10 VEGFC CAMK2G MAPK14 CSK UBC RASA4 SPTBN1 ABI1 DUSP2 LAMTOR3 SRC CAMK2D KRAS CAMK2B IL2 PIK3CA NRTN KIT CSF2RA KL PRKCD PSMD9 PSMB2 EGFR MAPK11 MAP2K2 WASF2 CDH5 GRIN2A BAIAP2 HSP90AA1 VWF IRS2 FGFR4 IQGAP1 AKT1 PTPRA PSMB1 PHB VAV1 PSME1 FGB FGF3 PSMD3 HBEGF ERBB3 ITGA2B ROCK2 NCKAP1 VAV3 PPP2R5C KSR2 FGF18 PIK3CB AC010132.3 SPHK1 SHC2 FN1 RBX1 PSMD5 NF1 MAPK12 ARRB1 PRKACG FGFR1 FGF19 CYFIP1 PAK3 PSME2 FGF22 PSMD13 PSMB3 PSMA2 NRG2 CUL3 PSMB8 PDGFRB PSMC1 PSMD14 IL17RD SPTBN4 SH2D2A DUSP10 NRG1 SPRED3 ITGAV HSPB1 IL2RA IL3RA FGF1 CYBA ERBB4 DUSP6 MAPK13 MET CTNND1 FGA PTK2 NRP1 FLT1 SPTB JUP NRAS MAPKAPK3 FGF2 IL2RB PXN BTC NCF4 VEGFB PGF WASF3 RAPGEF2 IL5RA PPP2CB PSMB9 PPP2R5E NCF2 PSMF1 RASA2 NCK1 PSMA6 PSMC3 PSMC6 IRS1 MARK3 PPP2R1B ARRB2 RAP1A SHC3 BRAP NCKAP1L RASGRP3 PEBP1 PRKCB KDR UBB FGF16 GRIN2D FYN IL5 YWHAB FGF5 IL2RG CYBB RAF1 RANBP9 SPTA1 FRS3 VEGFA MAPK3 PSMA1 VCL GFRA2 PDGFRA CAMK2A ERBB2 NOS3 ITPR1 LAT GRIN1 GRB2 NRG3 UBA52 CALM2 GFRA3 RNASE1 PSPN PSMD11 PSMD7 PSME3 RASGRP1 HGF PAK2 FGFR2 DLG4 CNKSR2 NCAM1 PPP2R5D RASGRP4 PSMD12 PSMB5 PRKACB DOCK1 MAP2K1 WDR83 NRG4 RASAL2 CALM1 FRS2 BRK1 PEA15 PSMD6 JAK3 SPTBN5 PPP2R5A MAP3K11 PTK2B DUSP1 RHOA ACTN2 RPS27A CSF2RB DUSP9 RASA1 PRKACA SHB DUSP4 PSMA5 BCAR1 PRKCA DUSP16 CSF2 PIK3R2 FGF4 RASAL1 PDGFA FGF7 EREG PRR5 DUSP8 PPP2R5B SOS1 CDC42 SPRED1 SPTAN1 CAV1 KBTBD7 PSMD8 RET FGG PSMB11 PDPK1 ITPR3 AHCYL1 WASF1 GFRA1 FGF20 JAK2 RASGEF1A PIK3R1 PDGFB PSMD2 ARAF FGFR3 PSMA8 AXL NEFL PSMB10 FGF23 FLT4 MAPK1 PSMD4 NRP2 AKT3 RASA3 TRIB3 PSMA4 DUSP5 PSMB4 SPTBN2 VEGFD DAB2IP CTNNA1 MTOR ITGB3 PSMC5 GRIN2B ROCK1 BRAF PPP5C SEM1 PSMA7 PLCG1 ARTN SHC1 NCK2 ANGPT1 AKAP9 FGF17 PAK1 PSMA3 KITLG AKT2 FGF8 GDNF PPP2CA KLB SYNGAP1 FGF9 ELMO1 ITPR2 PAQR3 CRK CYFIP2 APBB1IP +REAC:1257604 PIP3 activates AKT signaling MTOR ERBB4 NR4A1 MET TSC2 AGO1 AKT3 PIP4K2A TNRC6B TRIB3 FOXO3 GSK3A MDM2 FGF1 PIP5K1A PHLPP1 PPP2CB KLB PPP2CA FGF8 CREB1 AKT2 CDKN1B BAD FGF9 PPP2R5E PIK3AP1 FOXO4 RPS6KB2 AKT1S1 AL358075.4 FGF2 ICOS BTC CDKN1A KITLG FGF17 PIK3CB PIK3R2 FGF4 FGF18 PIP4K2C FGF7 PDGFA PRR5 EREG PPP2R5B FGF19 FGFR1 VAV1 ERBB3 HBEGF FGF3 PPP2R5C PDGFRB PDGFB TNRC6C CD80 FGFR3 MIR26A2 TRAT1 FGF23 AGO3 PTPN11 PIP5K1B GAB1 MAPK1 LCK NRG1 TNRC6A MIR26A1 PDPK1 FGF22 CHUK FOXO1 NRG2 PIK3R1 FGF20 FGFR2 PPP2R5D SRC PIK3CA TP53 NRG4 MOV10 KIT PIP5K1C NRG3 PTEN CD19 INS HGF AGO2 PHLPP2 IRS2 PIK3CD FGFR4 PPP2R5A AKT1 AL672043.1 KL PIK3R3 EGFR FRS2 IER3 INSR MLST8 CD28 FYN AGO4 FGF16 THEM4 FGF5 IRS1 PPP2R1B FGF10 EGF MAPK3 GSK3B PDGFRA RICTOR ERBB2 CASP9 GRB2 PPP2R1A FGF6 MAPKAP1 PIP4K2B INS-IGF2 CD86 +REAC:212436 Generic Transcription Pathway ZNF776 ZNF736 ZNF700 CHM ZNF658B TP53AIP1 CASP10 RARG ZNF235 HUS1 ZNF200 ZNF17 ZNF664 RRM2B TFAP2C ZNF786 PSMB1 ZNF737 TAF5 NDUFA4 COX6B1 TOM1L1 ZNF493 ZNF649 NBN ZNF557 RFC5 POLR2I ZNF213 PRMT5 ZNF600 ZNF418 ZNF671 MAPK11 ZNF426 SRC TAF11 GTF2H4 BTG2 ZNF655 KIT ERCC2 ZNF677 ZNF709 ZNF234 ATAD2 SCO1 TAF9B ZNF28 ZNF691 MAPK14 ZNF584 ZNF317 CTGF ZNF445 ZNF492 ZNF771 KAT5 ZNF558 BCL6 TEAD3 TBL1X ZIM3 TAF7L ZNF157 ZNF136 ZNF415 ZNF792 BLM PSMD1 STK11 RICTOR NELFCD DDB2 ZNF446 SP1 ZNF727 NOTCH2 RUNX3 TRAPPC2 LAMTOR5 ZNF460 ZNF331 PSMB6 NKX2-5 ZKSCAN5 PPP2R1A MAPKAP1 CITED1 ZNF554 DNA2 MED1 SMAD3 ZNF681 CASP2 JUN ZNF20 ZNF839 ZNF14 CTNNB1 EP300 PSMC4 ZNF189 L3MBTL1 NDRG1 MED15 SPP1 ZNF567 RORB ZNF483 PRKAG2 KDM5B ZNF12 CCNT1 NOC2L CGA TNKS1BP1 NR2F1 RXRB RMI1 RABGGTB ZNF705E MT-CO3 CCNA1 ZNF697 GLS WWTR1 ESRRA BCL2L11 KRBOX4 PPP2CB CCND1 ZNF112 ZNF740 ZNF10 NR2E1 ZNF486 SMARCD3 PSMB9 PIN1 PSMF1 ELOC GTF2H5 NR2C2AP PSMC3 MYBL2 ZNF223 PSMA6 ZNF41 RABGGTA POLR2B ZNF225 CHD3 ZNF75A KAT6A MED26 HNF4A CNOT4 CENPJ RUNX2 DEK ZNF23 TCEA1 MBD3 ZNF540 BARD1 ZNF595 NR5A1 ZNF343 TXN PRDX1 ZNF33A WWOX MED24 BRD2 TSC2 POLR2D ZNF440 RAD1 GATA4 CTDP1 ZNF479 ZNF347 ZNF619 ZNF749 CSNK2B ZNF211 CDK13 CDK2 PPM1A ZNF256 FOXO3 ZNF433 SMURF2 ZNF37A COX11 ZNF227 TFAP2D ZNF33B ZNF133 PSMD14 BRPF1 ESRRB ZNF577 USP2 ITGAL PCNA UBE2I CITED2 YWHAE IGFBP3 ZNF224 ZNF772 BCL2L14 ZNF555 TAF1 BRCA1 NR3C2 NOP2 ZNF547 ZNF729 RBL2 TNRC6A ZNF706 CASP6 PLAGL1 CSNK2A2 SKIL HDAC1 RXRG CDKN2B PSME2 PSMB8 SMURF1 PSMA2 UBE2D3 PSMD13 AC010132.3 AC003002.1 CNOT11 ZFP1 PMS2 ATM ZNF385A ZNF304 ERCC3 ZNF519 TAF10 ZNF597 POLR2J PSME1 SUPT4H1 THRB TAF4 MNAT1 PARP1 ZNF160 ZNF230 PLK2 ZNF333 NR2E3 MAML3 ZNF684 BANP CNOT7 BNIP3L ZNF773 ZNF202 ZNF425 CDK9 TCF7L2 ZNF692 ZNF710 ZSCAN25 ZNF180 ZNF670 ZNF510 GATAD2A MT-CO1 ZNF552 COX14 RPS27A BRPF3 NRBP1 MAPKAPK5 HDAC2 CDK1 ZNF568 ZNF221 GTF2F1 COX5B BRIP1 AURKB ZNF208 TFDP1 ZNF667 COX7A2L RGCC RAD9A BRD7 ZNF717 PSMD12 ZNF571 POLR2F ZNF614 MYC UBA52 PTEN MED6 SUPT16H PSMD7 NR1H3 PRDX2 PSME3 CDKN2A PRKAA1 ZNF155 COX16 ATRIP SMAD2 ZFP14 NR5A2 ZNF468 ZNF607 GATAD2B RBBP7 PRDX5 RRAGA ZNF680 NUAK1 SMAD4 VEGFA ZNF471 NCOR1 ZNF79 TCF7 RXRA COX19 NPPA GTF2H3 RNF34 ZNF613 ING2 UBB AGO4 CSNK2A1 MED10 CITED4 ZNF778 ZNF282 PPARA CDK5 ZNF429 ZKSCAN1 PRKAB1 ELOA ZNF138 TMEM219 ZNF70 ZNF431 RPA2 ZNF26 SCO2 CCNH TRIM28 RARA ZKSCAN8 RUNX1 GLS2 ZNF735 PPP2CA ZNF543 RAD51D ZNF582 APAF1 ZNF720 ZNF782 EXO1 LAMTOR4 NR1H4 KCTD15 ZFP28 CNOT2 CCNE2 PSMA7 TGS1 RPA1 ZNF19 NR3C1 PSMA3 ZNF337 TP53BP2 ZNF586 ZSCAN32 SURF1 MTOR COX18 POLR2G SESN3 CNOT6 GTF2H1 PSMC5 ZNF714 NR4A1 AGO1 ZNF716 CNOT6L ZNF154 ZNF92 THRA ZNF775 RAD50 AR PSMD4 TBX5 BRD1 ZNF490 ZNF324B ZNF263 MAML2 ZNF212 PSMA4 E2F7 MED17 TAF4B MED27 POU4F1 ZNF254 PSMB4 ZNF18 ZIM2 ZIK1 ZNF790 ZNF641 TGIF1 ELOA3D ELOA3B CHD4 CRADD HELZ2 ZNF222 COX8A AGO3 RBBP8 ZNF561 ELL ZNF302 MDC1 MEN1 RORC HKR1 PDPK1 KAT2B PMAIP1 ZNF589 ZNF585A MED7 PRELID1 E2F5 NOTCH3 ZNF544 ZNF257 SMYD2 ZNF248 NR1H2 TFDP2 PIP4K2C ZNF267 ELOB TNFRSF10C PRMT1 ELOA2 CCNT2 ZNF253 YY1 TMEM55B ZNF573 ZNF559 TP53I3 ZNF724 NEDD4L ZFHX3 ZNF702P NRBF2 ZNF436 JAG1 ZNF443 ESRRG NR2F6 ZNF761 JUNB FANCC MEAF6 LEF1 ZNF514 NLRC4 CCNA2 ESR2 ZNF34 RBL1 ZNF606 CCNB1 BBC3 AKT1 TNFRSF10B POLR2E VDR ITGA4 ZNF668 MED13 SMAD7 ZNF682 ZNF774 CDK12 PSMD9 PSMB2 ZNF688 EGFR ZNF675 NR2C2 ZNF662 PIDD1 ZNF141 FOS ZNF777 PRKAA2 ZNF564 MED20 ZNF3 ZNF484 KRAS MED25 ZNF99 SUPT5H ZNF430 ZNF268 ZNF570 RFFL NR6A1 DYRK2 ZNF135 CASP1 UBC BAX WRN PLK3 LAMTOR3 TAF7 ZNF214 PITX2 ATP1B4 RAD17 ZNF708 CYCS NOTCH4 TAF3 ZNF705A COX20 POLR2A PHF20 CDK5R1 TAF12 ZNF383 PSMD10 ZNF703 ZNF705D ZKSCAN4 ZNF611 ZNF419 CGB8 ZNF197 HDAC4 TFAP2A CNOT8 POLR2L TRIM33 COX7C ZNF620 ZNF665 ZNF454 ZNF799 KMT5A AC002310.5 PSMB7 POU4F2 TGIF2 TBL1XR1 RPTOR TBP ZNF354C RARB CREBBP MLST8 ZNF77 ZNF566 RRAGD LAMTOR2 TACO1 TP63 FANCI CNOT3 ZNF626 PSMC2 COX6A1 CHEK2 CBFB ZFP37 ZNF287 ZNF718 DAXX RBBP4 CCNE1 NCOA1 TRIAP1 ZNF615 PRKAG1 PRDM7 NR1D1 GADD45A RAD9B TAF13 ZNF730 ZNF610 E2F4 ZNF721 CDC25C ZNF517 HSPD1 CDKN1B MED16 CCNK RHEB NCOA6 ATR ZNF300 ZNF770 MT-CO2 CGB5 ZNF696 MAMLD1 ZNF750 NR4A3 ZNF658 CDKN1A ZNF528 AURKA YAP1 MAML1 ZNF195 TEAD4 ZNF689 NOTCH1 CNOT1 RBPJ PERP ZNF599 ZNF556 NR1I3 ZNF205 ZNF439 CNOT10 AIFM2 ZNF506 ZNF669 PRDM1 ZNF266 NR0B2 ZNF100 COX4I1 YWHAZ TNRC6B ZNF746 YWHAH POLR2K ZNF624 ZNF184 ZNF548 ESR1 PRELID3A TCF7L1 ZFP69B PSMC1 GPI TNRC6C STEAP3 ZNF676 TSC1 MED14 EHMT2 YWHAQ ZNF114 ING5 TP53INP1 CCNG1 TIGAR ZNF530 GSR SETD9 ZNF804B ZNF747 ZNF354B ZNF678 PSMB3 YEATS4 PPP1R13L ZNF273 MRE11 ZNF587 G6PD ZNF585B PSMD5 NELFB ZNF75D NR1D2 ZNF101 ZNF699 ZNF473 TEAD1 ZNF660 ZNF767P PPP1R13B ZNF398 ZNF442 ZNF565 ZNF563 SERPINE1 PSMD3 CCNC SSRP1 ZNF350 COX7B ZNF711 ZNF285 PPP2R5C ZNF286A ZNF704 ZNF500 ZNF461 FANCD2 PPARG TNFRSF10D PSMD6 ZNF860 KCTD1 ZNF416 RHNO1 CARM1 SNW1 ZNF562 NR1I2 ZNF394 SESN1 ZNF583 CHEK1 LRPPRC ZNF264 CDK7 TPX2 ELOA3 NCOR2 PPARD PRKAG3 BID ZNF549 ZNF785 RRAGB KRBA1 TEAD2 MSH2 COX6C ZNF840P HES1 ZNF71 PSMB5 TP53 ZNF334 MOV10 HIPK1 ZNF529 ZNF354A TFAP2B ZNF485 MED4 HNF4G PSMD11 ZNF726 AGO2 ZNF43 MAP2K6 PSMA1 TP73 TXNRD1 LAMTOR1 AC134772.2 BIRC5 POLR2H COX5A ERBB2 JMY ZNF124 TAF1L TP53RK MTA2 ZNF791 MED30 NPM1 ZNF605 PIP4K2B ZFP30 ZNF496 ZNF226 RFC2 NELFE ZNF480 MED23 HIPK2 YWHAB MLH1 SLC38A9 PSMC6 TAF2 ZKSCAN7 ZNF30 TTC5 PCBP4 GTF2H2 PPP2R1B ZFP69 TOP3A TOPBP1 ZNF233 CDK8 USP9X ZNF546 ZNF701 CHD9 ZNF324 ZKSCAN3 AKT2 ZNF215 ARID3A PRKAB2 MED8 RMI2 ZNF793 ZNF732 ZNF74 ZNF738 MED31 SEM1 NELFA ZNF560 ZNF627 ZNF25 ZFP90 ZNF551 TNFRSF10A SUMO1 ZNF596 NR0B1 GPX2 ZNF311 APOE RFC4 NCOA2 ZNF705G E2F8 USP7 GTF2F2 ZNF250 AKT3 NR2C1 MED12 PML RRAGC ZNF713 PIP4K2A ZNF616 ZNF274 RORA ZNF569 CNOT9 RNF111 TGFB1 ZNF2 MDM2 ATF2 SFN MDM4 ZNF432 PSMD2 ZFP2 FAS MIR26A2 PSMB10 POLR2C E2F1 TAF9 ZNF621 TAF6 MIR26A1 CGB3 ZNF420 EHMT1 TGFA PSMD8 RPA3 ZNF625 PGR SGK1 KAT2A ZNF764 ZNF382 ZNF707 ZNF45 RFC3 TFAP2E SESN2 NR4A2 ZNF320 PRR5 ZNF470 ZNF140 ZNF441 SKI UBE2D1 ZNF175 DDIT4 ZNF679 PSMA5 YWHAG ZNF169 ZNF417 ZNF550 +REAC:74752 Signaling by Insulin receptor GRIN2A IRS2 VWF FGFR4 PHB AKT1 PSMB1 IQGAP1 PTPRA PDE3B KL PSMD9 PSMB2 EGFR MAP2K2 PRKAA2 KRAS SRC CAMK2D PIK3CA NRTN CAMK2B IL2 PIK3C3 ATP6V1G2 KIT CSF2RA ATP6V1A UBC CSK RASA4 SPTBN1 DUSP2 LAMTOR3 GFRA4 TEK STK11 PSMD1 PSMD10 CAMK2G RASAL3 LAMTOR5 PPP2R1A FGF6 PSMB6 IL3 CNKSR1 ATP6V0D2 TLR9 RASGRF2 ATP6V0E2 GRIN2C PSMB7 ATP6V1H TLN1 PSMC4 HRAS RPTOR MLST8 PRKAG2 RRAGD THEM4 LAMTOR2 DUSP7 CALM3 RASGRF1 RAP1B PSMC2 KSR1 EIF4E JAK1 SPRED2 FGF10 PSME4 PRKAG1 EGF PPP2CB IL5RA PSMB9 RASA2 PPP2R5E PSMF1 PSMA6 PSMC3 RHEB FGF2 IL2RB ATP6V0A1 BTC RAPGEF2 DUSP6 ERBB4 FGA MET PTK2 TSC2 SPTB NRAS SPRED3 PPM1A FGF1 IL3RA IL2RA RPS6 IL17RD PSMC1 PDGFRB ATP6V0B PSMD14 DUSP10 SPTBN4 TSC1 NRG1 EIF4EBP1 ATP6V1G3 FGF22 PSME2 CAB39L CUL3 NRG2 PSMB8 STRADB PSMA2 TCIRG1 PSMD13 PSMB3 PIK3CB AC010132.3 FGF18 FN1 SHC2 RBX1 EEF2K PSMD5 FGF19 NF1 ARRB1 FGFR1 FGB PSME1 PSMD3 ITGA2B HBEGF ERBB3 FGF3 KSR2 PPP2R5C PEA15 PSMD6 ATP6V1C1 SPTBN5 JAK3 ACTN2 MAP3K11 PPP2R5A DUSP1 DUSP9 RPS27A CSF2RB RASAL2 CALM1 PRKAG3 FRS2 ATP6V1D RRAGB CAB39 FGFR2 DLG4 PPP2R5D CNKSR2 NCAM1 RASGRP4 PSMB5 PSMD12 WDR83 NRG4 MAP2K1 NRG3 CALM2 ATP6V1B2 UBA52 PSMD7 ATP6V1F GFRA3 PSPN PSMD11 INS ATP6V1E1 RASGRP1 HGF ATP6V0E1 PRKAA1 PSME3 PIK3R4 PSMA1 MAPK3 PDGFRA LAMTOR1 CAMK2A VCL GFRA2 ERBB2 GRIN1 GRB2 ATP6V0A2 RPS6KB1 LAT ATP6V0D1 RAF1 RRAGA SPTA1 RANBP9 INS-IGF2 FRS3 RASGRP3 SHC3 BRAP INSR ATP6V1G1 PEBP1 GRIN2D FYN IL5 YWHAB UBB FGF16 IL2RG FGF5 PSMC6 SLC38A9 IRS1 GRB10 PPP2R1B ARRB2 MARK3 PRKAB1 ATP6V0C ATP6V0A4 RAP1A STRADA KLB GDNF AKT2 FGF8 PPP2CA FGF9 PRKAB2 PAQR3 SYNGAP1 APBB1IP LAMTOR4 SEM1 PPP5C AKT1S1 PSMA7 SHC1 ARTN PSMA3 KITLG EIF4G1 ANGPT1 AKAP9 ATP6V1C2 FGF17 MTOR GRIN2B ITGB3 PSMC5 BRAF PSMD4 RRAGC TRIB3 ATP6AP1 RASA3 PSMA4 SPTBN2 DAB2IP DUSP5 PSMB4 ARAF PSMD2 PDGFB PSMA8 FGFR3 NEFL PSMB10 PTPN11 FGF23 GAB1 EIF4B MAPK1 SPTAN1 SPRED1 PSMB11 PDPK1 KBTBD7 RET FGG PSMD8 ATP6V1B1 GFRA1 PIK3R1 FGF20 JAK2 RASGEF1A PIK3R2 FGF4 RASAL1 PDGFA FGF7 ATP6V1E2 EREG PPP2R5B SOS1 DUSP8 RASA1 PSMA5 DUSP4 CSF2 DUSP16 +REAC:186797 Signaling by PDGF KRAS CAMK2D SRC KIT CSF2RA RAPGEF1 NRTN COL9A2 PIK3CA IL2 CAMK2B RASA4 SPTBN1 UBC CSK PHLPP2 LAMTOR3 DUSP2 CD19 ADCY4 IRS2 VWF PIK3CD PDE1B GRIN2A PHB IQGAP1 PSMB1 AKT1 PRKAR1B PTPRA FGFR4 PSMD9 PSMB2 PRKCD KL MAP2K2 STAT5A PRKAR2B EGFR PSMC4 HRAS TLN1 SPP1 MLST8 ADCY3 CALM3 RASGRF1 DUSP7 LAMTOR2 THEM4 ADCY1 GRB7 JAK1 COL4A1 PSMC2 RAP1B KSR1 COL6A5 PSME4 EGF SPRED2 PDE1A FGF10 COL4A3 TEK PSMD1 RICTOR COL6A2 GFRA4 CASP9 CAMK2G PSMD10 IL3 MAPKAP1 THBS3 RASAL3 FGF6 PSMB6 PPP2R1A GRIN2C RASGRF2 CD86 PSMB7 CNKSR1 FGA MET PTK2 DUSP6 ERBB4 SPTB NRAS STAT5B TSC2 FOXO3 COL6A6 SPRED3 TNRC6B FGF1 IL3RA IL2RA PIP5K1A GSK3A PSMB9 PPP2CB IL5RA FOXO4 PSMA6 PSMC3 NCK1 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E ICOS BTC IL2RB FGF2 AL358075.4 RAPGEF2 CDKN1A ADCY2 RBX1 FN1 SHC2 AC010132.3 PIK3CB PRKCE FGF18 FGF19 ARRB1 FGFR1 PRKACG NF1 PSMD5 ERBB3 HBEGF ITGA2B PSMD3 FGF3 FGB PSME1 VAV1 PPP2R5C KSR2 TNRC6C CD80 IL17RD PSMD14 PSMC1 PDGFRB NRG1 DUSP10 PIP5K1B SPTBN4 TNRC6A PSMB8 CUL3 NRG2 PSMA2 PSMB3 PSMD13 CHUK FGF22 ADCY5 PSME2 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 NRG4 WDR83 MAP2K1 MOV10 PRKACB FURIN PSMB5 PSMD12 RASGRP4 PTPN12 TP53 CALM2 UBA52 THBS2 PTEN NRG3 PIP5K1C PDGFD HGF RASGRP1 AGO2 INS PSME3 STAT3 PLG PSMD7 PSMD11 PSPN GFRA3 SPTBN5 JAK3 ADCY8 PSMD6 PEA15 DUSP9 AL672043.1 RPS27A CSF2RB ACTN2 DUSP1 MAP3K11 PPP2R5A CALM1 RASAL2 ADCY9 PRKAR1A PIK3R3 FRS2 CD28 PEBP1 RASGRP3 THBS1 BRAP INSR IER3 SHC3 IL2RG FGF5 YWHAB IL5 GRIN2D FYN FGF16 COL4A2 UBB AGO4 IRS1 PSMC6 RAP1A ARRB2 PPP2R1B MARK3 PDGFRA CAMK2A GSK3B GFRA2 COL4A4 VCL PSMA1 MAPK3 GRB2 GRIN1 LAT COL6A3 ITPR1 ERBB2 SPTA1 PIP4K2B RANBP9 STAT1 RAF1 INS-IGF2 FRS3 GRIN2B PDE1C PSMC5 ITGB3 NR4A1 MTOR COL9A1 BRAF AGO1 TRIB3 COL6A1 RASA3 AKT3 PSMD4 PIP4K2A DAB2IP SPTBN2 PSMB4 COL9A3 DUSP5 MDM2 PSMA4 KLB GDNF FGF8 AKT2 CREB1 PPP2CA PHLPP1 CAMK4 APBB1IP CRK PAQR3 ITPR2 FGF9 BAD SYNGAP1 PLCG1 PSMA7 RPS6KB2 PDGFC SEM1 PPP5C AKT1S1 KITLG PSMA3 FGF17 AKAP9 ANGPT1 GRK2 SHC1 NCK2 PRKCG PLAT ARTN PIP4K2C PDGFA FGF7 RASAL1 PIK3R2 FGF4 SOS1 PPP2R5B DUSP8 PRR5 EREG COL4A5 PSMA5 DUSP4 PRKACA RASA1 STAT6 CSF2 ADCY7 DUSP16 PRKCA THBS4 BCAR1 NEFL FGFR3 PSMA8 PSMD2 CRKL ARAF PDGFB GAB1 LCK PRKAR2A MAPK1 MIR26A2 TRAT1 AGO3 FGF23 PTPN11 PSMB10 PDPK1 ITPR3 PSMB11 FGG RET PSMD8 KBTBD7 ADCY6 MIR26A1 SPRED1 SPTAN1 PIK3R1 JAK2 RASGEF1A FGF20 GFRA1 FOXO1 AHCYL1 +REAC:112412 SOS-mediated signalling CALM1 PSMD9 PSMB2 KL RASAL2 MAP2K2 EGFR FRS2 IRS2 VWF JAK3 SPTBN5 PSMD6 PEA15 GRIN2A DUSP9 PHB CSF2RB PSMB1 RPS27A IQGAP1 PTPRA FGFR4 ACTN2 DUSP1 PPP2R5A MAP3K11 CALM2 SPTBN1 RASA4 UBA52 CSK UBC NRG3 RASGRP1 HGF PSME3 LAMTOR3 PSMD7 DUSP2 PSMD11 GFRA3 PSPN PPP2R5D KRAS NCAM1 CAMK2D SRC CNKSR2 DLG4 FGFR2 NRG4 WDR83 CSF2RA MAP2K1 KIT NRTN PSMD12 PSMB5 RASGRP4 CAMK2B IL2 IL3 SPTA1 RANBP9 RASAL3 FGF6 PSMB6 PPP2R1A RAF1 RASGRF2 GRIN2C FRS3 PSMB7 CNKSR1 PDGFRA CAMK2A PSMD1 TEK GFRA2 VCL PSMA1 MAPK3 GFRA4 GRB2 GRIN1 CAMK2G LAT ERBB2 PSMD10 IRS1 JAK1 PSMC2 PSMC6 RAP1B KSR1 PSME4 RAP1A EGF SPRED2 ARRB2 PPP2R1B FGF10 MARK3 PSMC4 HRAS TLN1 PEBP1 RASGRP3 BRAP SHC3 RASGRF1 CALM3 DUSP7 IL2RG FGF5 IL5 YWHAB FYN GRIN2D FGF16 UBB LAMTOR2 PSMA7 BTC IL2RB SEM1 FGF2 PPP5C RAPGEF2 KITLG PSMA3 FGF17 ANGPT1 AKAP9 SHC1 ARTN KLB FGF8 PPP2CA GDNF PSMB9 PPP2CB IL5RA APBB1IP PSMA6 PSMC3 PAQR3 RASA2 FGF9 PSMF1 SYNGAP1 PPP2R5E RASA3 SPRED3 PSMD4 DAB2IP FGF1 SPTBN2 IL3RA IL2RA PSMB4 DUSP5 PSMA4 GRIN2B FGA ITGB3 PTK2 MET PSMC5 DUSP6 ERBB4 BRAF SPTB NRAS PSMB11 RET PSMD8 FGG KBTBD7 SPRED1 SPTAN1 PSMB8 NRG2 CUL3 PSMD13 PSMB3 PSMA2 JAK2 FGF20 RASGEF1A GFRA1 FGF22 PSME2 NEFL FGFR3 PSMA8 IL17RD PSMD2 ARAF PDGFB PSMD14 PDGFRB PSMC1 NRG1 MAPK1 DUSP10 PSMB10 FGF23 SPTBN4 ERBB3 HBEGF ITGA2B PSMD3 PSMA5 DUSP4 FGF3 FGB PSME1 RASA1 KSR2 CSF2 PPP2R5C DUSP16 RBX1 SHC2 FN1 PDGFA FGF7 AC010132.3 FGF18 RASAL1 FGF4 SOS1 PPP2R5B FGF19 ARRB1 DUSP8 FGFR1 NF1 PSMD5 EREG +REAC:3214842 HDMs demethylate histones HIST1H4C KDM6A KDM4C HIST1H4A KDM2B HIST1H3C HIST2H4A KDM5D HIST2H3A HIST1H3E JMJD6 HIST2H3C HIST1H4K HIST1H4J ARID5B HIST1H3F RIOX2 PHF2 KDM4B KDM3A HIST1H3G KDM5C HIST1H4E KDM1A HIST1H3H KDM1B UTY HIST1H4H HIST1H4L KDM7A KDM5B KDM4A HIST1H4D HIST2H4B HIST1H3B HIST1H3I HIST2H3D KDM4D HIST1H3D HIST1H3J HIST4H4 KDM3B KDM8 KDM2A HIST1H3A KDM5A HIST1H4I HIST1H4B KDM6B HIST1H4F PHF8 +REAC:1236394 Signaling by ERBB4 DUSP6 ERBB4 WWOX SH2B1 PTK2 FGA MET APH1A TSC2 NRAS SPTB STAT5B TNRC6B SPRED3 FOXO3 GSK3A ESR1 FGF1 IL3RA PIP5K1A IL2RA PPP2CB IL5RA PSMB9 RASA2 CDKN1B PSMF1 PPP2R5E PIK3AP1 FOXO4 PSMA6 PSMC3 FGF2 AL358075.4 ICOS BTC IL2RB CDKN1A RAPGEF2 YAP1 PIK3CB AC010132.3 FGF18 RBX1 FN1 SHC2 PSMD5 FGF19 ARRB1 FGFR1 NF1 FGB PSME1 VAV1 ERBB3 HBEGF ITGA2B PSMD3 FGF3 KSR2 PPP2R5C PSENEN IL17RD PSMD14 PSMC1 PDGFRB TNRC6C CD80 DUSP10 PIP5K1B SPTBN4 NRG1 CSN2 TNRC6A CHUK FGF22 PSME2 PSMB8 NRG2 CUL3 PSMA2 PSMB3 PSMD13 KRAS SRC CAMK2D NRTN PIK3CA CAMK2B IL2 KIT PRLR CSF2RA GFAP UBC CSK RASA4 SPTBN1 LAMTOR3 DUSP2 CD19 PHLPP2 GRIN2A IRS2 VWF PIK3CD FGFR4 PHB PSMB1 IQGAP1 PTPRA AKT1 GHR KL PSMD9 PSMB2 EGFR MAP2K2 BTRC STAT5A HRAS PSMC4 TLN1 MLST8 LAMTOR2 THEM4 CALM3 RASGRF1 DUSP7 PSMC2 RAP1B KSR1 JAK1 SPRED2 FGF10 PSME4 EGF GFRA4 S100B PSMD1 TEK PRL RICTOR PSMD10 CASP9 CAMK2G RASAL3 FGF6 PSMB6 PPP2R1A IL3 MAPKAP1 CNKSR1 GRIN2C RASGRF2 CD86 PSMB7 MTOR GRIN2B ITGB3 PSMC5 NR4A1 PSEN2 AGO1 BRAF AKT3 PIP4K2A PSMD4 TRIB3 RASA3 MDM2 PSMA4 DAB2IP SPTBN2 PSMB4 DUSP5 PHLPP1 KLB GDNF FGF8 PPP2CA AKT2 CREB1 PAQR3 BAD FGF9 SYNGAP1 APBB1IP RPS6KB2 SEM1 PPP5C AKT1S1 PSMA7 SHC1 ARTN KITLG PSMA3 FGF17 AKAP9 ANGPT1 RASAL1 PIK3R2 FGF4 PIP4K2C PDGFA FGF7 PRR5 EREG SOS1 ITCH PPP2R5B DUSP8 RASA1 PSMA5 DUSP4 CSF2 DUSP16 PSMD2 ARAF PDGFB NEFL PSMA8 FGFR3 TRAT1 MIR26A2 PTPN11 AGO3 FGF23 PSMB10 GAB1 LCK MAPK1 GH2 SPRED1 MIR26A1 SPTAN1 PDPK1 PSMB11 FGG PSMD8 RET KBTBD7 GFRA1 PGR FOXO1 PIK3R1 JAK2 NCSTN FGF20 RASGEF1A DLG4 FGFR2 PPP2R5D NCAM1 CNKSR2 RASGRP4 PSMB5 PSMD12 TP53 NRG4 WDR83 MAP2K1 MOV10 APH1B NRG3 PIP5K1C CALM2 UBA52 PTEN PSMD7 CXCL12 PSMD11 GFRA3 PSPN HGF RASGRP1 AGO2 INS PSME3 WWP1 PEA15 JAK3 SPTBN5 PSMD6 ACTN2 DUSP1 PPP2R5A CSH1 MAP3K11 DUSP9 AL672043.1 ADAM17 NEDD4 RPS27A CSF2RB RASAL2 CALM1 PIK3R3 FRS2 RASGRP3 INSR BRAP IER3 SHC3 CD28 PEBP1 IL5 YWHAB FYN GRIN2D UBB CUL1 FGF16 AGO4 IL2RG FGF5 PSMC6 IRS1 ARRB2 GH1 PPP2R1B MARK3 RAP1A PSMA1 MAPK3 CAMK2A PDGFRA GSK3B GFRA2 VCL ERBB2 GRB2 GRIN1 LAT RAF1 SPTA1 PIP4K2B RANBP9 SKP1 INS-IGF2 FRS3 TAB2 NCOR1 +REAC:449147 Signaling by Interleukins PSMD13 PSMA2 HIST1H3F TNIP2 PSMB8 IL25 PSME2 MUC1 CHUK FGF22 COL1A2 NRG1 CCL22 DUSP10 INPPL1 CD80 IL1R1 PSMD14 PDGFRB PTAFR IL17RD KSR2 MAOA IL11 FGF3 PSME1 VAV1 FGFR1 NF1 FGF19 SQSTM1 ALOX15 PIM1 HCK FGF18 AC010132.3 RAPGEF2 IL1B PTPN6 IL2RB IRAK2 LYN TAB1 TNFRSF1B PSMA6 PSMC3 OSM HSPA8 PSMF1 IL36A PSMB9 CCND1 NANOG IKBKG PPP2CB IL3RA FGF1 FCER2 FOXO3 PTGS2 SPRED3 STX3 SPTB MAPKAPK3 IL18 RPS6KA3 YES1 JUN CD86 GRIN2C IL17RA IL1RAP CXCL8 SYK IL3 PSMB6 MMP1 FGF6 PPP2R1A RASAL3 CAMK2G MEF2A LBP TEK VIM PSMD1 EGF SPRED2 IL33 KSR1 IL9 RIPK2 RAP1B RASGRF1 CALM3 DUSP7 TRAF6 CCL3L1 PSMC4 HIST2H3D BTRC MAPK11 TXLNA MMP9 TYK2 IL20RB PELI3 NOD2 IQGAP1 PSMB1 FSCN1 PTPRA ELK1 ITGAM FGFR4 VWF IRS2 GRIN2A HSP90AA1 TEC BCL6 IL7 DUSP2 RASA4 SPTBN1 UBE2V1 CSK MAPK14 CSF2RA KIT HIST1H3H CAMK2B ZEB1 CAMK2D SRC IL4R IL36B RASGEF1A PIK3R1 NDN GFRA1 IL17RE KBTBD7 RORC PSMB11 IL12A SPTAN1 IRAK4 IFNL3 PTPN11 FGF23 CSF1 IL1RL1 NEFL PELI2 IL17C VRK3 ARAF CSF2 DUSP4 STAT6 DUSP8 PPP2R5B EREG CXCL1 MAP2K7 FGF7 PDGFA NFKB2 CD36 MMP2 PIK3R2 IL19 FGF4 FGF17 ANGPT1 PSMA3 VCAM1 STX4 SHC1 OPRD1 PSMA7 PELI1 MCL1 PPP5C CRK PAQR3 PPP2CA CREB1 HIST1H3E GDNF HSP90B1 ITGAX PSMB4 IL16 PSMA4 RASA3 MEF2C IL17A PSMD4 MAPK7 CLCF1 PSMC5 ALOX5 GRIN2B TAB2 NFKB1 IL36G VEGFA FRS3 IL37 IL17RB SPTA1 IL32 IRAK3 RAF1 STAT1 IL12RB2 GRIN1 IGHG4 IL12B CCR2 PDGFRA PRTN3 MAPK3 BRWD1 ARRB2 RHOU IL6R IL34 IL22 UBB POMC PEBP1 HIST1H3D SHC3 IGHG1 CASP3 HIF1A IL1RN PIK3R3 CALM1 CDK1 RASAL2 SOCS1 AL672043.1 IFNLR1 RPS27A IL23A DUSP9 DUSP1 MAP3K7 MAP3K8 PPP2R5A NOS2 CCL2 PSME3 RASGRP1 HGF GFRA3 PSPN STAT3 PSMD7 IFNL2 UBA52 SMARCA4 CALM2 MYC NRG3 CCL3 NRG4 IL10 RAG2 BCL2 RASGRP4 PSMD12 IL1F10 CNKSR2 IL31 IL17RC IL6 DLG4 FGFR2 PSMB3 NRG2 CUL3 ANXA1 HMOX1 IL15RA LAMA5 SPTBN4 F13A1 INPP5D PSMC1 IL10RB IL24 ITGB1 PPP2R5C HIST1H3A IL18RAP ERBB3 ITGA2B HBEGF PSMD3 FGB ARRB1 STX1A PSMD5 CSF3 RPS6KA1 IL1RL2 RBX1 SHC2 FN1 PIK3CB CCR1 RPS6KA2 CDKN1A TWIST1 MAP2K3 BTC FGF2 AL358075.4 FLT3LG OPRM1 PPP2R5E RASA2 IL5RA IL17F IL2RA LIF SOCS5 IL31RA CEBPD YWHAZ NRAS IL4 STAT5B GATA3 OSMR S1PR1 IL15 MET FGA PTK2 IL20RA ERBB4 TIMP1 DUSP6 CCL19 IL1A PSMB7 RASGRF2 MAPKAPK2 CNKSR1 HIST1H3G PSMD10 IL9R GFRA4 IL20 PSME4 FGF10 JAK1 CBL IL6ST BCL2L1 IL22RA1 PSMC2 FPR1 HAVCR2 LAMTOR2 HRAS TLN1 STAT5A MAP2K2 FOS EGFR PSMB2 PSMD9 MMP3 IL22RA2 IL23R KL EBI3 AKT1 PHB PIK3CD MYD88 IL27 JUNB RPS6KA5 LAMTOR3 IRF4 ICAM1 UBC LCN2 CCL4 CASP1 RAPGEF1 IL2 NRTN CNTFR PIK3CA KRAS JAK2 FGF20 CXCL10 FOXO1 RET FGG PSMD8 CD4 NOD1 SPRED1 LCK MAPK1 PSMB10 HIST1H3C HIST2H3A RELA PSMA8 FGFR3 PDGFB PSMD2 LGALS9 CRKL DUSP16 IFNL1 CCL11 PSMA5 RASA1 PRKACA SOS1 BATF RASAL1 HIST1H3J AKAP9 KITLG CRLF1 ARTN SOX2 ATF1 UBE2N BLNK SEM1 MAP2K4 APBB1IP SYNGAP1 IL27RA FGF9 FGF8 CNTF HIST2H3C KLB IL10RA CTF1 DUSP5 DAB2IP SPTBN2 TNFRSF1A ATF2 TGFB1 RORA BRAF FBXW11 ITGB3 IL12RB1 CCL20 SKP1 IL18R1 CSF1R RANBP9 IGHE LAT GRB2 ERBB2 GFRA2 BIRC5 VCL CAMK2A PSMA1 MAP2K6 CXCL2 RAP1A IL7R NFKBIA MARK3 MAP3K3 PPP2R1B IL11RA IRS1 IL1R2 IRAK1 IL13RA1 PSMC6 FGF5 IL2RG CUL1 FGF16 YWHAB IL36RN IL5 GRIN2D FYN FASLG IL18BP GAB2 HIST1H3I BRAP SAA1 RASGRP3 TAB3 FRS2 SOCS3 CCL5 TOLLIP MAPK10 CSF2RB LIFR PTK2B MAP3K11 IL13 ACTN2 SPTBN5 JAK3 MAPK8 PSMD6 MAPK9 PEA15 TNF FLT3 DUSP3 PSMD11 IL13RA2 CCR5 RAG1 IKBKB MAP2K1 ITGB2 WDR83 TP53 POU2F1 PSMB5 NCAM1 PPP2R5D HIST1H3B CSF3R +REAC:1433557 Signaling by SCF-KIT SPTBN5 JAK3 PSMD6 PEA15 DUSP9 AL672043.1 SOCS1 CSF2RB RPS27A ACTN2 DUSP1 MAP3K11 PPP2R5A CALM1 RASAL2 CHEK1 PIK3R3 FRS2 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 NRG4 WDR83 MAP2K1 MOV10 PSMB5 PSMD12 RASGRP4 TP53 CALM2 UBA52 PTEN NRG3 PIP5K1C HGF AGO2 RASGRP1 INS PSME3 STAT3 PSMD7 PSMD11 GFRA3 PSPN RNASE1 PDGFRA CAMK2A GSK3B GFRA2 VCL PSMA1 MAPK3 GRB2 GRIN1 LAT ERBB2 SPTA1 PIP4K2B RANBP9 STAT1 RAF1 INS-IGF2 FRS3 GAB2 CD28 PEBP1 RASGRP3 INSR IER3 BRAP SHC3 IL2RG FGF5 YWHAB IL5 FYN GRIN2D UBB FGF16 AGO4 IRS1 GRB10 PSMC6 SOCS6 RAP1A ARRB2 PPP2R1B MARK3 KLB CREB1 GDNF FGF8 AKT2 PPP2CA PHLPP1 APBB1IP PAQR3 BAD FGF9 SYNGAP1 PSMA7 RPS6KB2 CMA1 SEM1 AKT1S1 PPP5C KITLG PSMA3 FGF17 ANGPT1 AKAP9 SHC1 ARTN GRIN2B ITGB3 PSMC5 NR4A1 MTOR BRAF AGO1 TRIB3 RASA3 AKT3 PIP4K2A SH2B2 PSMD4 DAB2IP SPTBN2 PSMB4 DUSP5 MDM2 PSMA4 NEFL FGFR3 PSMA8 ARAF PSMD2 PDGFB GAB1 LCK MAPK1 MIR26A2 TRAT1 PSMB10 PTPN11 AGO3 FGF23 PDPK1 PSMB11 FGG PSMD8 RET KBTBD7 SPRED1 MIR26A1 SPTAN1 PIK3R1 FGF20 RASGEF1A JAK2 GFRA1 FOXO1 FGF7 PIP4K2C PDGFA RASAL1 PIK3R2 FGF4 GRAP2 SOS1 PPP2R5B DUSP8 PRR5 EREG PSMA5 DUSP4 RASA1 CSF2 DUSP16 PRKCA IRS2 VWF PIK3CD TEC GRIN2A PHB IQGAP1 PSMB1 PTPRA AKT1 FGFR4 PTPRU PSMB2 PSMD9 KL MAP2K2 STAT5A EGFR MMP9 KRAS SRC CAMK2D KIT CSF2RA NRTN PIK3CA IL2 CAMK2B RASA4 SPTBN1 CSK UBC PHLPP2 LAMTOR3 CD19 DUSP2 TEK PSMD1 RICTOR GFRA4 CASP9 CAMK2G FER PSMD10 IL3 MAPKAP1 RASAL3 FGF6 PSMB6 FES PPP2R1A GRIN2C RASGRF2 PSMB7 CD86 GRAP CNKSR1 HRAS PSMC4 TLN1 MLST8 CALM3 RASGRF1 DUSP7 LAMTOR2 THEM4 CBL RAC1 GRB7 JAK1 PSMC2 RAP1B KSR1 PSME4 EGF SPRED2 FGF10 SH2B3 PSMB9 PPP2CB IL5RA FOXO4 PSMC3 PSMA6 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E LYN ICOS BTC IL2RB FGF2 AL358075.4 RAPGEF2 CDKN1A PTPN6 FGA MET PTK2 DUSP6 YES1 ERBB4 SPTB NRAS STAT5B TSC2 FOXO3 SPRED3 TNRC6B FGF1 IL3RA PIP5K1A IL2RA GSK3A CD80 TNRC6C IL17RD PSMD14 PSMC1 PDGFRB NRG1 DUSP10 PIP5K1B SPTBN4 TNRC6A PSMB8 NRG2 CUL3 PSMD13 PSMB3 PSMA2 CHUK FGF22 PSME2 RBX1 FN1 SHC2 PIK3CB AC010132.3 FGF18 FGF19 ARRB1 FGFR1 NF1 PSMD5 ERBB3 ITGA2B HBEGF PSMD3 FGF3 FGB VAV1 PSME1 PPP2R5C KSR2 +REAC:5654695 PI-3K cascade:FGFR2 GRB2 CASP9 ERBB2 PDGFRA GSK3B RICTOR MAPK3 INS-IGF2 CD86 MAPKAP1 PIP4K2B FGF6 PPP2R1A FGF5 FYN THEM4 FGF16 AGO4 CD28 MLST8 INSR IER3 EGF PPP2R1B FGF10 IRS1 AL672043.1 AKT1 FGFR4 PPP2R5A IRS2 PIK3CD EGFR PIK3R3 FRS2 KL NRG4 MOV10 KIT PIK3CA TP53 PPP2R5D SRC FGFR2 HGF AGO2 INS PHLPP2 CD19 PTEN NRG3 PIP5K1C GAB1 NRG1 LCK MAPK1 MIR26A2 TRAT1 AGO3 PIP5K1B PTPN11 FGF23 FGFR3 CD80 TNRC6C PDGFB PDGFRB PIK3R1 NRG2 FGF20 CHUK FGF22 FOXO1 PDPK1 MIR26A1 TNRC6A PPP2R5B FGF19 FGFR1 PRR5 EREG FGF7 PDGFA PIP4K2C PIK3CB FGF18 FGF4 PIK3R2 PPP2R5C ERBB3 HBEGF FGF3 VAV1 FOXO4 CDKN1B FGF9 BAD PPP2R5E PIK3AP1 KLB CREB1 FGF8 AKT2 PPP2CA PHLPP1 PPP2CB KITLG CDKN1A FGF17 ICOS BTC RPS6KB2 FGF2 AL358075.4 AKT1S1 AGO1 TSC2 MET NR4A1 MTOR ERBB4 FGF1 PIP5K1A MDM2 GSK3A TRIB3 FOXO3 AKT3 TNRC6B PIP4K2A +REAC:5654736 Signaling by FGFR1 FRS2 PIK3R3 PRKAR1A ADCY9 RASAL2 CALM1 MAP3K11 PPP2R5A DUSP1 ACTN2 RPS27A CSF2RB AL672043.1 DUSP9 PEA15 PSMD6 ADCY8 JAK3 SPTBN5 FLRT2 GFRA3 PSPN PSMD11 PSMD7 PSME3 INS HGF AGO2 RASGRP1 PIP5K1C NRG3 PTEN UBA52 CALM2 TP53 PSMD12 PSMB5 RASGRP4 PRKACB FGFRL1 MAP2K1 MOV10 WDR83 NRG4 FGFR2 DLG4 CNKSR2 NCAM1 PPP2R5D FRS3 INS-IGF2 RAF1 RANBP9 PIP4K2B SPTA1 ERBB2 ITPR1 LAT GRIN1 GRB2 MAPK3 PSMA1 VCL GFRA2 GSK3B CAMK2A PDGFRA MARK3 PPP2R1B ARRB2 RAP1A PSMC6 IRS1 AGO4 UBB FGF16 FYN GRIN2D IL5 YWHAB FGF5 IL2RG SHC3 BRAP INSR IER3 RASGRP3 PEBP1 CD28 PRKCG SPRY2 ARTN SHC1 ANGPT1 AKAP9 GRK2 FGF17 PSMA3 KITLG AKT1S1 PPP5C SEM1 RPS6KB2 PSMA7 PLCG1 SYNGAP1 ITPR2 FGF9 BAD PAQR3 APBB1IP CAMK4 PHLPP1 PPP2CA GDNF CREB1 AKT2 FGF8 KLB FLRT1 PSMA4 MDM2 DUSP5 PSMB4 SPTBN2 DAB2IP PIP4K2A PSMD4 AKT3 RASA3 TRIB3 AGO1 BRAF ANOS1 MTOR NR4A1 PSMC5 ITGB3 PDE1C GRIN2B AHCYL1 FOXO1 GFRA1 FGF20 JAK2 RASGEF1A PIK3R1 SPRED1 MIR26A1 SPTAN1 ADCY6 KBTBD7 FGG RET PSMD8 PSMB11 ITPR3 PDPK1 PTPN11 FGF23 PSMB10 AGO3 TRAT1 MIR26A2 PRKAR2A MAPK1 MKNK1 LCK GAB1 PDGFB ARAF PSMD2 PSMA8 FGFR3 NEFL PRKCA DUSP16 CSF2 ADCY7 RASA1 PRKACA DUSP4 PSMA5 EREG PRR5 DUSP8 PPP2R5B SOS1 FGF4 PIK3R2 RASAL1 PDGFA PIP4K2C FGF7 EGFR PRKAR2B MAP2K2 KL PRKCD PSMB2 PSMD9 FGFR4 AKT1 PSMB1 PRKAR1B PTPRA IQGAP1 PHB GRIN2A PDE1B PIK3CD VWF IRS2 ADCY4 CD19 DUSP2 LAMTOR3 PHLPP2 UBC CSK RASA4 SPTBN1 CAMK2B IL2 PIK3CA NRTN KIT CSF2RA SRC CAMK2D KRAS CNKSR1 PSMB7 CD86 RASGRF2 GRIN2C PPP2R1A PSMB6 FGF6 RASAL3 IL3 MAPKAP1 PSMD10 CAMK2G CASP9 GFRA4 RICTOR TEK PSMD1 PDE1A FGF10 SPRED2 EGF PSME4 KSR1 RAP1B PSMC2 JAK1 ADCY1 CBL THEM4 LAMTOR2 DUSP7 CALM3 RASGRF1 ADCY3 MLST8 TLN1 HRAS PSMC4 ADCY2 RAPGEF2 CDKN1A AL358075.4 FGF2 IL2RB BTC ICOS PIK3AP1 PPP2R5E PSMF1 CDKN1B RASA2 PSMA6 PSMC3 FOXO4 IL5RA FLRT3 PPP2CB PSMB9 GSK3A IL2RA IL3RA PIP5K1A FGF1 TNRC6B SPRED3 FOXO3 TSC2 NRAS SPTB ERBB4 DUSP6 FGA MET PTK2 PSME2 FGF22 ADCY5 CHUK PSMA2 PSMB3 PSMD13 NRG2 CUL3 PSMB8 TNRC6A SPTBN4 PIP5K1B DUSP10 NRG1 PDGFRB PSMC1 PSMD14 IL17RD TNRC6C CD80 KSR2 PPP2R5C VAV1 PSME1 FGB FGF3 PSMD3 ITGA2B HBEGF ERBB3 PSMD5 NF1 ARRB1 PRKACG FGFR1 FGF19 PRKCE FGF18 AC010132.3 PIK3CB SHC2 FN1 RBX1 +REAC:2172127 DAP12 interactions WDR83 NRG4 PRKACB MAP2K1 MOV10 PSMB5 PSMD12 RASGRP4 TP53 PPP2R5D CNKSR2 NCAM1 FGFR2 DLG4 INS HGF RASGRP1 AGO2 PSME3 PSMD7 RNASE1 PSPN GFRA3 PSMD11 CALM2 PTEN UBA52 CD300LB PIP5K1C NRG3 DUSP9 RPS27A CSF2RB AL672043.1 HLA-E ACTN2 MAP3K11 PPP2R5A DUSP1 PSMD6 JAK3 SPTBN5 ADCY8 PEA15 PRKAR1A ADCY9 PIK3R3 FRS2 CALM1 RASAL2 IL2RG FGF5 FYN GRIN2D YWHAB IL5 AGO4 FGF16 UBB PEBP1 CD28 RASGRP3 SHC3 BRAP INSR IER3 BTK RAP1A PLCG2 PPP2R1B ARRB2 MARK3 IRS1 PSMC6 GRIN1 GRB2 LAT ITPR1 KLRC2 LCP2 ERBB2 GSK3B CAMK2A PDGFRA VCL GFRA2 PSMA1 KLRK1 MAPK3 INS-IGF2 FRS3 SPTA1 CLEC5A RANBP9 PIP4K2B RAF1 BRAF AGO1 KLRD1 PDE1C GRIN2B NR4A1 ITGB3 PSMC5 MTOR SPTBN2 DAB2IP DUSP5 PSMB4 PSMA4 MDM2 TRIB3 RASA3 AKT3 PIP4K2A PSMD4 APBB1IP ITPR2 FGF9 BAD PAQR3 SYNGAP1 KLB CREB1 AKT2 PPP2CA FGF8 GDNF PHLPP1 CAMK4 PSMA3 KITLG GRK2 AKAP9 ANGPT1 FGF17 SHC1 ARTN PRKCG PLCG1 PSMA7 SEM1 RPS6KB2 PPP5C AKT1S1 PPP2R5B GRAP2 SOS1 DUSP8 PRR5 TYROBP EREG PDGFA PIP4K2C FGF7 SIGLEC14 PIK3R2 FGF4 RASAL1 CSF2 ADCY7 DUSP16 PRKCA PSMA5 DUSP4 PRKACA RASA1 GAB1 PRKAR2A TREM2 MAPK1 LCK TRAT1 MIR26A2 FGF23 PSMB10 PTPN11 AGO3 FGFR3 PSMA8 NEFL PSMD2 ARAF PDGFB PIK3R1 SIGLEC16 JAK2 FGF20 B2M RASGEF1A GFRA1 AHCYL1 FOXO1 PSMB11 ITPR3 PDPK1 KBTBD7 RET PSMD8 FGG ADCY6 MIR26A1 SPTAN1 SPRED1 CSF2RA KIT PIK3CA NRTN CAMK2B IL2 KRAS CAMK2D SRC KIR2DS4 NCR2 PHLPP2 DUSP2 CD19 LAMTOR3 ADCY4 RASA4 SPTBN1 CSK UBC PHB IQGAP1 PSMB1 PTPRA AKT1 PRKAR1B FGFR4 IRS2 VWF PIK3CD PDE1B GRIN2A MAP2K2 PRKAR2B EGFR PSMB2 PSMD9 KL PRKCD DUSP7 CALM3 RASGRF1 VAV2 THEM4 LAMTOR2 TLN1 PSMC4 HRAS MLST8 ADCY3 PSME4 EGF SPRED2 FGF10 PDE1A RAC1 ADCY1 JAK1 RAP1B PSMC2 KSR1 CASP9 CAMK2G PSMD10 PSMD1 TEK RICTOR GFRA4 RASGRF2 GRIN2C CD86 PSMB7 CNKSR1 IL3 MAPKAP1 SYK RASAL3 PPP2R1A PSMB6 FGF6 HLA-B SPTB NRAS TSC2 FGA MET PTK2 DUSP6 ERBB4 FGF1 IL2RA IL3RA PIP5K1A GSK3A FOXO3 CD300E SPRED3 TNRC6B FOXO4 PSMC3 PSMA6 CDKN1B RASA2 PPP2R5E PIK3AP1 PSMF1 PSMB9 PPP2CB IL5RA ADCY2 RAPGEF2 CDKN1A ICOS IL2RB BTC AL358075.4 FGF2 FGF19 NF1 FGFR1 PRKACG ARRB1 PSMD5 SHC2 FN1 RBX1 AC010132.3 PIK3CB FGF18 PRKCE KSR2 PPP2R5C HLA-C VAV3 TREM1 PSMD3 HBEGF ITGA2B ERBB3 FGF3 FGB PSME1 VAV1 NRG1 SIGLEC15 DUSP10 SPTBN4 PIP5K1B CD80 TNRC6C SIRPB1 IL17RD PSMC1 PDGFRB PSMD14 NRG2 CUL3 PSMB8 PSMA2 PSMB3 PSMD13 ADCY5 FGF22 CHUK PSME2 TNRC6A +REAC:5655253 Signaling by FGFR2 in disease NRAS FGF5 POLR2F GTF2F2 SOS1 FGF16 POLR2D PIK3CA FGF7 NCBP1 HRAS KRAS POLR2G FGF18 FGF4 FGFR2 FGF1 FGF10 POLR2K FGF3 POLR2J GRB2 GAB1 FGF23 POLR2C FGF9 POLR2H FGF8 POLR2A FGF17 FGF20 PIK3R1 GTF2F1 FRS2 POLR2I FGF22 POLR2L PLCG1 NCBP2 FGF2 FGF6 POLR2E POLR2B +REAC:5673000 RAF activation PPP2CB ARAF BRAP HRAS KRAS PPP2R5D PPP2CA SRC YWHAB PPP2R5A MAP3K11 PPP2R5E BRAF PPP2R5B PHB MAP2K1 NRAS KSR1 RAF1 PPP2R1A PPP2R1B MARK3 MAP2K2 PPP2R5C JAK2 +REAC:448424 Interleukin-17 signaling PSMC4 HRAS TLN1 LAMTOR2 TRAF6 RASGRF1 CALM3 DUSP7 KSR1 PSMC2 RIPK2 RAP1B JAK1 IL6ST FGF10 SPRED2 EGF PSME4 GFRA4 TEK PSMD1 PSMD10 CAMK2G MEF2A FGF6 PSMB6 PPP2R1A RASAL3 IL3 IL17RA CNKSR1 PSMB7 JUN GRIN2C RASGRF2 MAPKAPK2 SRC CAMK2D KRAS IL2 CAMK2B NRTN CSF2RA KIT UBC CSK MAPK14 SPTBN1 RASA4 UBE2V1 LAMTOR3 DUSP2 GRIN2A RPS6KA5 VWF IRS2 FGFR4 PSMB1 IQGAP1 PTPRA ELK1 PHB NOD2 KL PSMB2 PSMD9 EGFR TYK2 BTRC MAPK11 FOS MAP2K2 FGF18 AC010132.3 RPS6KA1 RBX1 SHC2 FN1 PSMD5 ARRB1 FGFR1 NF1 FGF19 PSME1 FGB FGF3 ERBB3 ITGA2B HBEGF PSMD3 PPP2R5C KSR2 PSMD14 PSMC1 PDGFRB IL17RD SPTBN4 DUSP10 NRG1 PSME2 CHUK FGF22 PSMB3 PSMA2 PSMD13 PSMB8 TNIP2 NRG2 CUL3 IL25 ERBB4 DUSP6 PTK2 RPS6KA3 MET FGA NRAS SPTB MAPKAPK3 SPRED3 IL2RA IL3RA FGF1 IL17F IL5RA PPP2CB IKBKG PSMB9 PSMF1 PPP2R5E RASA2 PSMC3 PSMA6 FGF2 TAB1 BTC IL2RB IRAK2 RPS6KA2 RAPGEF2 MAP2K3 BRAP SHC3 RASGRP3 PEBP1 UBB FGF16 CUL1 YWHAB IL5 FYN GRIN2D FGF5 IL2RG PSMC6 IL6R IRS1 IRAK1 MARK3 ARRB2 PPP2R1B RAP1A MAPK3 MAP2K6 PSMA1 GFRA2 VCL PDGFRA CAMK2A ERBB2 LAT GRB2 GRIN1 RAF1 IL17RB RANBP9 SPTA1 SKP1 TAB2 NFKB1 FRS3 DLG4 IL6 FGFR2 NCAM1 CNKSR2 PPP2R5D IL17RC RASGRP4 PSMB5 PSMD12 MAP2K1 NRG4 WDR83 NRG3 IKBKB UBA52 CALM2 PSMD11 PSPN GFRA3 PSMD7 PSME3 DUSP3 HGF RASGRP1 PEA15 SPTBN5 JAK3 MAPK8 PSMD6 MAPK9 MAP3K7 DUSP1 MAP3K11 MAP3K8 PPP2R5A ACTN2 CSF2RB RPS27A DUSP9 MAPK10 RASAL2 CALM1 CDK1 FRS2 TAB3 RASAL1 FGF4 PDGFA FGF7 EREG MAP2K7 DUSP8 SOS1 PPP2R5B RASA1 DUSP4 PSMA5 DUSP16 CSF2 PDGFB IL17C VRK3 ARAF PSMD2 NEFL FGFR3 PSMA8 FGF23 PTPN11 PSMB10 MAPK1 SPRED1 SPTAN1 RET PSMD8 FGG KBTBD7 IL17RE PSMB11 NOD1 GFRA1 JAK2 RASGEF1A FGF20 ITGB3 PSMC5 GRIN2B MAPK7 BRAF FBXW11 PSMD4 RASA3 MEF2C IL17A PSMA4 ATF2 PSMB4 DUSP5 DAB2IP SPTBN2 FGF8 PPP2CA GDNF CREB1 KLB SYNGAP1 PAQR3 FGF9 MAP2K4 APBB1IP PPP5C SEM1 ATF1 PSMA7 UBE2N ARTN SHC1 FGF17 AKAP9 ANGPT1 KITLG PSMA3 +REAC:190236 Signaling by FGFR MAPKAP1 POLR2L IL3 RASAL3 FGF6 PSMB6 PPP2R1A GRIN2C RASGRF2 PSMB7 CD86 CNKSR1 POLR2A PSMD1 TEK HNRNPM RICTOR GFRA4 CASP9 CAMK2G PSMD10 CBL ADCY1 JAK1 RBFOX2 PSMC2 RAP1B KSR1 PSME4 EGF SPRED2 PDE1A FGF10 PSMC4 HRAS TLN1 NCBP1 MLST8 FGFBP1 ADCY3 HNRNPA1 CALM3 RASGRF1 DUSP7 THEM4 LAMTOR2 HNRNPF PSMB2 PSMD9 POLR2E PRKCD KL MAP2K2 PRKAR2B EGFR POLR2I IRS2 PIK3CD VWF PDE1B GRIN2A PHB PRKAR1B IQGAP1 AKT1 PTPRA PSMB1 FGFR4 RASA4 SPTBN1 CSK UBC PHLPP2 LAMTOR3 DUSP2 FGFBP2 CD19 ADCY4 KRAS SRC CAMK2D KIT CSF2RA NRTN PIK3CA CAMK2B IL2 TNRC6A PSMB8 NRG2 CUL3 ESRP1 PSMD13 PSMA2 PSMB3 CHUK ADCY5 FGF22 PSME2 TNRC6C CD80 IL17RD PSMD14 PDGFRB PSMC1 NRG1 DUSP10 TIA1 PIP5K1B SPTBN4 HBEGF ERBB3 ITGA2B PSMD3 FGF3 FGB POLR2J VAV1 PSME1 PPP2R5C KSR2 RBX1 SHC2 FN1 PIK3CB AC010132.3 PRKCE FGF18 FGF19 ARRB1 PRKACG FGFR1 NF1 PSMD5 ICOS BTC IL2RB POLR2B FGF2 AL358075.4 CDKN1A RAPGEF2 ADCY2 PSMB9 PPP2CB IL5RA FLRT3 ESRP2 FOXO4 PSMC3 PSMA6 RASA2 CDKN1B PSMF1 PIK3AP1 PPP2R5E FOXO3 HNRNPH1 SPRED3 TNRC6B FGF1 IL2RA PIP5K1A IL3RA GSK3A POLR2K MET FGA PTK2 DUSP6 ERBB4 NRAS SPTB POLR2D TSC2 SPTA1 PIP4K2B RANBP9 RAF1 FRS3 INS-IGF2 CAMK2A PDGFRA GSK3B GFRA2 POLR2H VCL PSMA1 MAPK3 GRB2 GRIN1 LAT ITPR1 ERBB2 TIAL1 IRS1 PSMC6 RAP1A ARRB2 PPP2R1B MARK3 CD28 PEBP1 RASGRP3 BRAP IER3 INSR SHC3 IL2RG FGF5 IL5 YWHAB GRIN2D FYN UBB FGF16 AGO4 CALM1 RASAL2 GTF2F1 ADCY9 PRKAR1A PIK3R3 FRS2 FLRT2 JAK3 ADCY8 SPTBN5 PSMD6 PEA15 DUSP9 AL672043.1 GALNT3 RPS27A CSF2RB ACTN2 DUSP1 MAP3K11 PPP2R5A CALM2 UBA52 PTEN NRG3 PIP5K1C RASGRP1 HGF AGO2 INS PSME3 PSMD7 PSMD11 PSPN GFRA3 PPP2R5D NCAM1 CNKSR2 DLG4 FGFR2 NRG4 WDR83 POLR2F MAP2K1 MOV10 FGFRL1 PRKACB PSMB5 PSMD12 RASGRP4 TP53 PDPK1 ITPR3 NCBP2 PSMB11 PSMD8 RET FGG KBTBD7 ADCY6 MIR26A1 SPRED1 SPTAN1 PIK3R1 FGF20 JAK2 RASGEF1A GFRA1 FOXO1 AHCYL1 NEFL FGFR3 PSMA8 PSMD2 ARAF PDGFB GAB1 LCK MAPK1 MKNK1 PRKAR2A TRAT1 MIR26A2 PTBP1 PSMB10 FGF23 AGO3 POLR2C PTPN11 PSMA5 DUSP4 PRKACA RASA1 CSF2 ADCY7 DUSP16 FGFBP3 PRKCA PIP4K2C PDGFA FGF7 RASAL1 FGF4 PIK3R2 SOS1 PPP2R5B DUSP8 PRR5 EREG PLCG1 PSMA7 RPS6KB2 SEM1 PPP5C AKT1S1 KITLG PSMA3 FGF17 GRK2 ANGPT1 AKAP9 SHC1 PRKCG ARTN SPRY2 FLRT1 KLB CREB1 GDNF FGF8 AKT2 PPP2CA PHLPP1 CAMK4 APBB1IP PAQR3 ITPR2 FGF9 BAD SYNGAP1 TRIB3 RASA3 AKT3 PSMD4 PIP4K2A DAB2IP SPTBN2 PSMB4 DUSP5 MDM2 PSMA4 GRIN2B PDE1C PSMC5 ITGB3 NR4A1 ANOS1 MTOR POLR2G BRAF GTF2F2 AGO1 diff -Nru activepathways-2.0.2/inst/extdata/enrichmentMap__pathways.txt activepathways-2.0.3/inst/extdata/enrichmentMap__pathways.txt --- activepathways-2.0.2/inst/extdata/enrichmentMap__pathways.txt 2023-10-02 01:21:34.000000000 +0000 +++ activepathways-2.0.3/inst/extdata/enrichmentMap__pathways.txt 2023-10-31 18:58:47.000000000 +0000 @@ -1,21 +1,34 @@ -term.id term.name adjusted.p.val +term_id term_name adjusted_p_val REAC:2424491 DAP12 signaling 4.49126833230489e-05 -REAC:422475 Axon guidance 0.0202896586319552 -REAC:177929 Signaling by EGFR 0.000624573372270557 +REAC:422475 Axon guidance 0.00046259184602835 +REAC:177929 Signaling by EGFR 0.000619750411866923 REAC:2559583 Cellular Senescence 6.59544666946083e-05 -REAC:180292 GAB1 signalosome 0.0121527722598693 -REAC:2262752 Cellular responses to stress 0.000910077434071759 -REAC:198203 PI3K/AKT activation 0.0121527722598693 -REAC:1257604 PIP3 activates AKT signaling 0.0114406907252397 -REAC:212436 Generic Transcription Pathway 0.00996914687235758 -REAC:186797 Signaling by PDGF 0.000812873899959487 -REAC:3214842 HDMs demethylate histones 0.00817140392344946 -REAC:1236394 Signaling by ERBB4 0.000366484426260168 -REAC:449147 Signaling by Interleukins 0.00535291019683162 -REAC:1433557 Signaling by SCF-KIT 0.000333497801266957 -REAC:5654695 PI-3K cascade:FGFR2 0.0114406907252397 -REAC:5654736 Signaling by FGFR1 0.000432188861733433 +REAC:5654699 SHC-mediated cascade:FGFR2 0.0284446360025451 +REAC:2428924 IGF1R signaling cascade 0.00472765617433565 +REAC:167044 Signalling to RAS 0.00725674706700891 +REAC:5654700 FRS-mediated FGFR2 signaling 0.0038328186164029 +REAC:187687 Signalling to ERKs 0.0110412411912787 +REAC:180336 SHC1 events in EGFR signaling 0.0036184063767845 +REAC:4420097 VEGFA-VEGFR2 Pathway 0.00399592999211922 +REAC:112399 IRS-mediated signalling 0.00376912151604491 +REAC:5654712 FRS-mediated FGFR4 signaling 0.0038328186164029 +REAC:180292 GAB1 signalosome 0.011469483859716 +REAC:2262752 Cellular responses to stress 0.000906522444094916 +REAC:198203 PI3K/AKT activation 0.00491448952862143 +REAC:194138 Signaling by VEGF 0.0061305631670633 +REAC:1257604 PIP3 activates AKT signaling 0.0108481449904663 +REAC:212436 Generic Transcription Pathway 0.00945486548608516 +REAC:74752 Signaling by Insulin receptor 0.00701199797493265 +REAC:186797 Signaling by PDGF 0.000806572551897785 +REAC:112412 SOS-mediated signalling 0.0036184063767845 +REAC:3214842 HDMs demethylate histones 0.00775152941354889 +REAC:1236394 Signaling by ERBB4 0.000365080271370282 +REAC:449147 Signaling by Interleukins 0.00289259718940152 +REAC:1433557 Signaling by SCF-KIT 0.000332224908895709 +REAC:5654695 PI-3K cascade:FGFR2 0.0108481449904663 +REAC:5654736 Signaling by FGFR1 0.000430526596880612 REAC:2172127 DAP12 interactions 6.09352718405167e-05 -REAC:5655253 Signaling by FGFR2 in disease 0.0211090824777934 -REAC:5673000 RAF activation 0.00417200044714473 -REAC:190236 Signaling by FGFR 0.00084584387241409 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'Fisher_directional', 'DPM', 'Stouffer_directional', and 'Strube_directional' methods perform directional integration. The 'scores_direction' and 'constraints_vector' parameters must be provided. diff -Nru activepathways-2.0.2/vignettes/ActivePathways-vignette.Rmd activepathways-2.0.3/vignettes/ActivePathways-vignette.Rmd --- activepathways-2.0.2/vignettes/ActivePathways-vignette.Rmd 2023-10-02 04:01:37.000000000 +0000 +++ activepathways-2.0.3/vignettes/ActivePathways-vignette.Rmd 2023-10-31 19:23:17.000000000 +0000 @@ -26,6 +26,11 @@ ActivePathways is a tool for multivariate pathway enrichment analysis that identifies gene sets, such as pathways or Gene Ontology terms, that are over-represented in a list or matrix of genes. ActivePathways uses a data fusion method to combine multiple omics datasets, prioritizes genes based on the significance and direction of signals from the omics datasets, and performs pathway enrichment analysis of these prioritized genes. We can find pathways and genes supported by single or multiple omics datasets, as well as additional genes and pathways that are only apparent through data integration and remain undetected in any single dataset alone. +The new version of ActivePathways is described in our recent preprint. + +Mykhaylo Slobodyanyuk^, Alexander T. Bahcheli^, Zoe P. Klein, Masroor Bayati, Lisa J. Strug, Jüri Reimand. Directional integration and pathway enrichment analysis for multi-omics data. bioRxiv (2023-09-24) (^ - co-first authors) +https://www.biorxiv.org/content/10.1101/2023.09.23.559116v1 + The first version of ActivePathways was published in Nature Communications with the PCAWG Pan-Cancer project. Marta Paczkowska\^, Jonathan Barenboim\^, Nardnisa Sintupisut, Natalie S. Fox, Helen Zhu, Diala Abd-Rabbo, Miles W. Mee, Paul C. Boutros, PCAWG Drivers and Functional Interpretation Working Group, PCAWG Consortium, Juri Reimand. Integrative pathway enrichment analysis of multivariate omics data. Nature Communications 11 735 (2020) (\^ - co-first authors) @@ -161,7 +166,7 @@ directional_merged_pvals["PIK3R4"] ``` -To assess the impact of the directional penalty on gene merged P-value signals we create a plot showing directional results on the y axis and non-directional results on the x. Green dots are prioritised hits, red dots are penalised. +To assess the impact of the directional penalty on gene merged P-value signals we create a plot showing directional results on the y axis and non-directional results on the x. Blue dots are prioritised hits, red dots are penalised. ```{r} lineplot_df <- data.frame(original = -log10(merged_pvals), @@ -170,15 +175,16 @@ ggplot(lineplot_df) + geom_point(size = 2.4, shape = 19, aes(original, modified, - color = ifelse(modified <= -log10(0.05), "#de2d26", "#2ca25f"))) + + color = ifelse(original <= -log10(0.05),"gray", + ifelse(modified > -log10(0.05),"#1F449C","#F05039")))) + labs(title = "", x ="Merged -log10(P)", y = "Directional Merged -log10(P)") + geom_hline(yintercept = 1.301, linetype = "dashed", - col = 'black', linewidth = 0.5) + + col = 'black', size = 0.5) + geom_vline(xintercept = 1.301, linetype = "dashed", - col = "black", linewidth = 0.5) + - geom_abline(linewidth = 0.5, slope = 1,intercept = 0) + + col = "black", size = 0.5) + + geom_abline(size = 0.5, slope = 1,intercept = 0) + scale_color_identity() ``` @@ -472,7 +478,7 @@ 1. Cytoscape, see 2. EnrichmentMap app of Cytoscape, see menu Apps\>App manager or -3. EhancedGraphics app of Cytoscape, see menu Apps\>App manager or +3. EnhancedGraphics app of Cytoscape, see menu Apps\>App manager or ## Required files @@ -595,6 +601,9 @@ # References +- Mykhaylo Slobodyanyuk^, Alexander T. Bahcheli^, Zoe P. Klein, Masroor Bayati, Lisa J. Strug, Jüri Reimand. Directional integration and pathway enrichment analysis for multi-omics data. bioRxiv (2023-09-24) (^ - co-first authors) +. + - Integrative Pathway Enrichment Analysis of Multivariate Omics Data. Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group; Reimand J, PCAWG Consortium. Nature Communications (2020) . - Pathway Enrichment Analysis and Visualization of Omics Data Using g:Profiler, GSEA, Cytoscape and EnrichmentMap. Reimand J, Isserlin R, Voisin V, Kucera M, Tannus-Lopes C, Rostamianfar A, Wadi L, Meyer M, Wong J, Xu C, Merico D, Bader GD. Nature Protocols (2019) . 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Mykhaylo Slobodyanyuk, Jonathan Barenboim and Juri Reimand

2023-10-02

2023-10-31

Constraints vector intuition

Creating the enrichment map

Alternative node coloring

References