Comment 23 for bug 28840

I ran into this too when trying to use a USB headset through a hub. From the description of the kernel config variable, it seems that this problem is only triggered when plugging a USB 1.x sound device into a USB 2.0 hub:

config USB_EHCI_SPLIT_ISO
        bool "Full speed ISO transactions (EXPERIMENTAL)"
        depends on USB_EHCI_HCD && EXPERIMENTAL
        default n
        ---help---
          This code is new and hasn't been used with many different
          EHCI or USB 2.0 transaction translator implementations.
          It should work for ISO-OUT transfers, like audio.