Comment 7 for bug 1989100

It looks like, do to a recent update in how libvirt handles /run/libvirt/qemu/swtpm/*.pid, swtpm blocks it. I created a PPA for 22.10 that updates the apparmor profile, located here: https://launchpad.net/~lvoytek/+archive/ubuntu/swtpm-fix-apparmor-libvirt

If you would like to test it you can run the following:

$ sudo add-apt-repository ppa:lvoytek/swtpm-fix-apparmor-libvirt
$ sudo apt update
$ sudo apt upgrade

Alternatively you can add the following line to /etc/apparmor.d/local/usr.bin.swtpm:

/run/libvirt/qemu/swtpm/*.pid rwk,

Let me know if this fixes it.
Thanks!