Nanopore analysis of differential RNA modifications

 RNA is transcribed from DNA, possibly spliced and exported to the
 cytoplasm - fine - but its bases can also be modified, edited, and
 not all such modifications are visible by Sanger sequencing methods
 and its derivatives.
 .
 The Nanopore measures potentials, and if the bases have a different
 shape then this is measured - not necessarily in an interpretable manner,
 something must be left for mass spectrometry, but one may be pointed
 to a difference. And maybe one can even statistically associate such
 differences with a molecular or clinical phenotype.