Protein Variation Effect Analyzer

 PROVEAN (Protein Variation Effect Analyzer) is a software tool which predicts
 whether an amino acid substitution or indel has an impact on the biological
 function of a protein.
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 PROVEAN is useful for filtering sequence variants to identify nonsynonymous or
 indel variants that are predicted to be functionally important.
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 The performance of PROVEAN is comparable to popular tools such as SIFT or
 PolyPhen-2.
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 A fast computation approach to obtain pairwise sequence alignment scores
 enabled the generation of precomputed PROVEAN predictions for 20 single AA
 substitutions and a single AA deletion at every amino acid position of all
 protein sequences in human and mouse.