multiple genome alignment algorithms

 The mauveAligner and progressiveMauve alignment algorithms have been
 implemented as command-line programs included with the downloadable Mauve
 software. When run from the command-line, these programs provide options
 not yet available in the graphical interface.
 .
 Mauve is a system for efficiently constructing multiple genome alignments
 in the presence of large-scale evolutionary events such as rearrangement
 and inversion. Multiple genome alignment provides a basis for research
 into comparative genomics and the study of evolutionary dynamics. Aligning
 whole genomes is a fundamentally different problem than aligning short
 sequences.
 .
 Mauve has been developed with the idea that a multiple genome aligner
 should require only modest computational resources. It employs algorithmic
 techniques that scale well in the amount of sequence being aligned. For
 example, a pair of Y. pestis genomes can be aligned in under a minute,
 while a group of 9 divergent Enterobacterial genomes can be aligned in
 a few hours.
 .
 Mauve computes and interactively visualizes genome sequence comparisons.
 Using FastA or GenBank sequence data, Mauve constructs multiple genome
 alignments that identify large-scale rearrangement, gene gain, gene loss,
 indels, and nucleotide substutition.
 .
 Mauve is developed at the University of Wisconsin.