a. Zope can't set a cookie for consumption by another application that doesn't expect the quotes. Yes, you could change the other application to deal with the quotes -- why should you have to?
b. If another application sets unquoted cookies, it can break Zope's parsing. This has happened to me, and it was very mysterious and unpleasant.
The incompatibility arises in two ways:
a. Zope can't set a cookie for consumption by another application that doesn't expect the quotes. Yes, you could change the other application to deal with the quotes -- why should you have to?
b. If another application sets unquoted cookies, it can break Zope's parsing. This has happened to me, and it was very mysterious and unpleasant.