The mauveAligner and progressiveMauve alignment algorithms have been
implemented as command-line programs included with the downloadable Mauve
software. When run from the command-line, these programs provide options
not yet available in the graphical interface.
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Mauve is a system for efficiently constructing multiple genome alignments
in the presence of large-scale evolutionary events such as rearrangement
and inversion. Multiple genome alignment provides a basis for research
into comparative genomics and the study of evolutionary dynamics. Aligning
whole genomes is a fundamentally different problem than aligning short
sequences.
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Mauve has been developed with the idea that a multiple genome aligner
should require only modest computational resources. It employs algorithmic
techniques that scale well in the amount of sequence being aligned. For
example, a pair of Y. pestis genomes can be aligned in under a minute,
while a group of 9 divergent Enterobacterial genomes can be aligned in
a few hours.
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Mauve computes and interactively visualizes genome sequence comparisons.
Using FastA or GenBank sequence data, Mauve constructs multiple genome
alignments that identify large-scale rearrangement, gene gain, gene loss,
indels, and nucleotide substutition.
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Mauve is developed at the University of Wisconsin.
